1CZI

CHYMOSIN COMPLEX WITH THE INHIBITOR CP-113972

Functional Information from GO Data

Chain	GOid	namespace	contents
E	0004190	molecular_function	aspartic-type endopeptidase activity
E	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	ACTIVE SITE.

Chain	Residue
E	ASP32

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site_id	AC2
Number of Residues	1
Details	ACTIVE SITE.

Chain	Residue
E	ASP215

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site_id	AC3
Number of Residues	19
Details	BINDING SITE FOR CHAIN P OF CP-113972 (NORSTATINE-S-METHYL CYSTEINE-IODO-PHENYLALANINE-

Chain	Residue
E	VAL111
E	PHE112
E	PHE117
E	ILE120
E	ILE213
E	ASP215
E	GLY217
E	THR218
E	SER219
E	LYS220
E	GLN287
E	ILE300
E	SER12
E	GLN13
E	ASP32
E	GLY34
E	TYR75
E	GLY76
E	THR77

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Functional Information from PROSITE/UniProt

site_id	PS00141
Number of Residues	12
Details	ASP_PROTEASE Eukaryotic and viral aspartyl proteases active site. VLFDTGSSDFWV

Chain	Residue	Details
E	VAL29-VAL40
E	ALA212-GLY223

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10094, ECO:0000269|PubMed:329280, ECO:0000269|PubMed:4612029

Chain	Residue	Details
E	ASP32
E	ASP215

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP32

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215

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site_id	CSA3
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	THR218
E	ASP32

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site_id	CSA4
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR216
E	ASP32
E	THR33

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site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	SER35
E	ASP32

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site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	TYR75
E	SER35
E	ASP32

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site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1am5

Chain	Residue	Details
E	ASP215
E	THR218
E	ASP32
E	THR33

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