1CZ3
DIHYDROFOLATE REDUCTASE FROM THERMOTOGA MARITIMA
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004146 | molecular_function | dihydrofolate reductase activity |
A | 0005829 | cellular_component | cytosol |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0042802 | molecular_function | identical protein binding |
A | 0046452 | biological_process | dihydrofolate metabolic process |
A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
A | 0046655 | biological_process | folic acid metabolic process |
A | 0050661 | molecular_function | NADP binding |
B | 0004146 | molecular_function | dihydrofolate reductase activity |
B | 0005829 | cellular_component | cytosol |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0042802 | molecular_function | identical protein binding |
B | 0046452 | biological_process | dihydrofolate metabolic process |
B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
B | 0046655 | biological_process | folic acid metabolic process |
B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE SO4 A 200 |
Chain | Residue |
A | GLY44 |
A | ILE46 |
A | THR47 |
A | GLY101 |
A | GLY102 |
A | LYS103 |
A | THR104 |
A | VAL105 |
A | HOH701 |
site_id | AC2 |
Number of Residues | 10 |
Details | BINDING SITE FOR RESIDUE SO4 B 300 |
Chain | Residue |
B | GLY44 |
B | ARG45 |
B | ILE46 |
B | THR47 |
B | GLY101 |
B | GLY102 |
B | LYS103 |
B | THR104 |
B | VAL105 |
B | HOH529 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 10 |
Details | BINDING: BINDING => ECO:0000305|PubMed:10731419 |
Chain | Residue | Details |
A | VAL6 | |
B | ILE100 | |
A | ASP27 | |
A | ARG53 | |
A | ARG58 | |
A | ILE100 | |
B | VAL6 | |
B | ASP27 | |
B | ARG53 | |
B | ARG58 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:10731419 |
Chain | Residue | Details |
A | ALA8 | |
B | THR64 | |
B | GLY80 | |
B | GLY102 | |
A | ILE15 | |
A | ARG45 | |
A | THR64 | |
A | GLY80 | |
A | GLY102 | |
B | ALA8 | |
B | ILE15 | |
B | ARG45 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
A | VAL19 | |
A | ASP27 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dhf |
Chain | Residue | Details |
B | VAL19 | |
B | ASP27 |