1CS8
CRYSTAL STRUCTURE OF PROCATHEPSIN L
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001968 | molecular_function | fibronectin binding |
| A | 0002250 | biological_process | adaptive immune response |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005518 | molecular_function | collagen binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005764 | cellular_component | lysosome |
| A | 0005771 | cellular_component | multivesicular body |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0016324 | cellular_component | apical plasma membrane |
| A | 0016540 | biological_process | protein autoprocessing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019064 | biological_process | fusion of virus membrane with host plasma membrane |
| A | 0019065 | biological_process | receptor-mediated endocytosis of virus by host cell |
| A | 0019882 | biological_process | antigen processing and presentation |
| A | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| A | 0030574 | biological_process | collagen catabolic process |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031638 | biological_process | zymogen activation |
| A | 0034230 | biological_process | enkephalin processing |
| A | 0036021 | cellular_component | endolysosome lumen |
| A | 0039654 | biological_process | fusion of virus membrane with host endosome membrane |
| A | 0042393 | molecular_function | histone binding |
| A | 0042583 | cellular_component | chromaffin granule |
| A | 0043202 | cellular_component | lysosomal lumen |
| A | 0043373 | biological_process | CD4-positive, alpha-beta T cell lineage commitment |
| A | 0043394 | molecular_function | proteoglycan binding |
| A | 0046718 | biological_process | symbiont entry into host cell |
| A | 0048002 | biological_process | antigen processing and presentation of peptide antigen |
| A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
| A | 0060309 | biological_process | elastin catabolic process |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071682 | cellular_component | endocytic vesicle lumen |
| A | 0071888 | biological_process | macrophage apoptotic process |
| A | 0097067 | biological_process | cellular response to thyroid hormone stimulus |
| A | 0097655 | molecular_function | serpin family protein binding |
Functional Information from PROSITE/UniProt
| site_id | PS00139 |
| Number of Residues | 12 |
| Details | THIOL_PROTEASE_CYS Eukaryotic thiol (cysteine) proteases cysteine active site. QGqCGSCWAfSA |
| Chain | Residue | Details |
| A | GLN19-ALA30 |
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MDHGVLVVGYG |
| Chain | Residue | Details |
| A | MET161-GLY171 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvKNSWgeeWGmgGYVkM |
| Chain | Residue | Details |
| A | TYR182-MET201 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 95 |
| Details | Propeptide: {"description":"Activation peptide","featureId":"PRO_0000026244","evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Propeptide: {"featureId":"PRO_0000026246"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Active site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 11 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"37990007","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"8HFV","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | Site: {"description":"Cleavage; by autolysis","evidences":[{"source":"PubMed","id":"9468501","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | ASN187 | |
| A | HIS163 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | GLN19 | |
| A | HIS163 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1pad |
| Chain | Residue | Details |
| A | ASN187 | |
| A | GLN19 | |
| A | HIS163 |
