1CR2

CRYSTAL STRUCTURE OF THE HELICASE DOMAIN OF THE GENE 4 PROTEIN OF BACTERIOPHAGE T7: COMPLEX WITH DATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003678	molecular_function	DNA helicase activity
A	0003697	molecular_function	single-stranded DNA binding
A	0005524	molecular_function	ATP binding
A	0006260	biological_process	DNA replication
A	0043139	molecular_function	5'-3' DNA helicase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 601

Chain	Residue
A	THR293
A	GLY294
A	ASN296
A	ASP297
A	ARG404
A	LYS408

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 602

Chain	Residue
A	ARG361
A	ARG363
A	GLN364

---

site_id	AC3
Number of Residues	18
Details	BINDING SITE FOR RESIDUE DTP A 600

Chain	Residue
A	SER314
A	GLY315
A	MET316
A	GLY317
A	LYS318
A	SER319
A	THR320
A	ARG361
A	ARG363
A	HIS465
A	ARG504
A	VAL514
A	PHE523
A	THR524
A	GLY525
A	TYR535
A	HOH606
A	HOH619

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04154","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	Site: {"description":"dTTP/dATP binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04154","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10892646","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Site: {"description":"dTTP/dATP binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04154","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10535735","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	3
Details	Site: {"description":"dTTP/dATP binding","evidences":[{"source":"HAMAP-Rule","id":"MF_04154","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10535735","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"10892646","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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