1CNT

CILIARY NEUROTROPHIC FACTOR

Functional Information from GO Data

Chain	GOid	namespace	contents
1	0005125	molecular_function	cytokine activity
1	0005127	molecular_function	ciliary neurotrophic factor receptor binding
1	0005138	molecular_function	interleukin-6 receptor binding
1	0005515	molecular_function	protein binding
1	0005576	cellular_component	extracellular region
1	0005615	cellular_component	extracellular space
1	0005737	cellular_component	cytoplasm
1	0007165	biological_process	signal transduction
1	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
1	0007399	biological_process	nervous system development
1	0008083	molecular_function	growth factor activity
1	0010628	biological_process	positive regulation of gene expression
1	0019221	biological_process	cytokine-mediated signaling pathway
1	0030154	biological_process	cell differentiation
1	0030424	cellular_component	axon
1	0032991	cellular_component	protein-containing complex
1	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
1	0043025	cellular_component	neuronal cell body
1	0043067	biological_process	regulation of programmed cell death
1	0043524	biological_process	negative regulation of neuron apoptotic process
1	0044877	molecular_function	protein-containing complex binding
1	0048143	biological_process	astrocyte activation
1	0048680	biological_process	positive regulation of axon regeneration
1	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
1	0070446	biological_process	negative regulation of oligodendrocyte progenitor proliferation
1	0097386	cellular_component	glial cell projection
1	0097696	biological_process	cell surface receptor signaling pathway via STAT
2	0005125	molecular_function	cytokine activity
2	0005127	molecular_function	ciliary neurotrophic factor receptor binding
2	0005138	molecular_function	interleukin-6 receptor binding
2	0005515	molecular_function	protein binding
2	0005576	cellular_component	extracellular region
2	0005615	cellular_component	extracellular space
2	0005737	cellular_component	cytoplasm
2	0007165	biological_process	signal transduction
2	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
2	0007399	biological_process	nervous system development
2	0008083	molecular_function	growth factor activity
2	0010628	biological_process	positive regulation of gene expression
2	0019221	biological_process	cytokine-mediated signaling pathway
2	0030154	biological_process	cell differentiation
2	0030424	cellular_component	axon
2	0032991	cellular_component	protein-containing complex
2	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
2	0043025	cellular_component	neuronal cell body
2	0043067	biological_process	regulation of programmed cell death
2	0043524	biological_process	negative regulation of neuron apoptotic process
2	0044877	molecular_function	protein-containing complex binding
2	0048143	biological_process	astrocyte activation
2	0048680	biological_process	positive regulation of axon regeneration
2	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
2	0070446	biological_process	negative regulation of oligodendrocyte progenitor proliferation
2	0097386	cellular_component	glial cell projection
2	0097696	biological_process	cell surface receptor signaling pathway via STAT
3	0005125	molecular_function	cytokine activity
3	0005127	molecular_function	ciliary neurotrophic factor receptor binding
3	0005138	molecular_function	interleukin-6 receptor binding
3	0005515	molecular_function	protein binding
3	0005576	cellular_component	extracellular region
3	0005615	cellular_component	extracellular space
3	0005737	cellular_component	cytoplasm
3	0007165	biological_process	signal transduction
3	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
3	0007399	biological_process	nervous system development
3	0008083	molecular_function	growth factor activity
3	0010628	biological_process	positive regulation of gene expression
3	0019221	biological_process	cytokine-mediated signaling pathway
3	0030154	biological_process	cell differentiation
3	0030424	cellular_component	axon
3	0032991	cellular_component	protein-containing complex
3	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
3	0043025	cellular_component	neuronal cell body
3	0043067	biological_process	regulation of programmed cell death
3	0043524	biological_process	negative regulation of neuron apoptotic process
3	0044877	molecular_function	protein-containing complex binding
3	0048143	biological_process	astrocyte activation
3	0048680	biological_process	positive regulation of axon regeneration
3	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
3	0070446	biological_process	negative regulation of oligodendrocyte progenitor proliferation
3	0097386	cellular_component	glial cell projection
3	0097696	biological_process	cell surface receptor signaling pathway via STAT
4	0005125	molecular_function	cytokine activity
4	0005127	molecular_function	ciliary neurotrophic factor receptor binding
4	0005138	molecular_function	interleukin-6 receptor binding
4	0005515	molecular_function	protein binding
4	0005576	cellular_component	extracellular region
4	0005615	cellular_component	extracellular space
4	0005737	cellular_component	cytoplasm
4	0007165	biological_process	signal transduction
4	0007259	biological_process	cell surface receptor signaling pathway via JAK-STAT
4	0007399	biological_process	nervous system development
4	0008083	molecular_function	growth factor activity
4	0010628	biological_process	positive regulation of gene expression
4	0019221	biological_process	cytokine-mediated signaling pathway
4	0030154	biological_process	cell differentiation
4	0030424	cellular_component	axon
4	0032991	cellular_component	protein-containing complex
4	0042531	biological_process	positive regulation of tyrosine phosphorylation of STAT protein
4	0043025	cellular_component	neuronal cell body
4	0043067	biological_process	regulation of programmed cell death
4	0043524	biological_process	negative regulation of neuron apoptotic process
4	0044877	molecular_function	protein-containing complex binding
4	0048143	biological_process	astrocyte activation
4	0048680	biological_process	positive regulation of axon regeneration
4	0070120	biological_process	ciliary neurotrophic factor-mediated signaling pathway
4	0070446	biological_process	negative regulation of oligodendrocyte progenitor proliferation
4	0097386	cellular_component	glial cell projection
4	0097696	biological_process	cell surface receptor signaling pathway via STAT

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE YB 3 188

Chain	Residue
2	GLU164
2	GLN167
2	HOH931
3	SO4189

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 3 189

Chain	Residue
3	YB188
2	LYS160
2	GLU164
3	ARG25
3	ILE173
3	ARG177

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 1 190

Chain	Residue
1	HIS12
1	ARG13
1	ARG14
1	THR184
1	HOH192
1	HOH194
1	HOH830

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 1 191

Chain	Residue
1	ARG25
1	ARG28
1	ILE173
1	HOH875

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site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 3 192

Chain	Residue
2	TRP168
3	ARG25
3	ARG177
3	HOH952

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