1CM8
PHOSPHORYLATED MAP KINASE P38-GAMMA
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000165 | biological_process | MAPK cascade |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004672 | molecular_function | protein kinase activity |
| A | 0004674 | molecular_function | protein serine/threonine kinase activity |
| A | 0004707 | molecular_function | MAP kinase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005654 | cellular_component | nucleoplasm |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006351 | biological_process | DNA-templated transcription |
| A | 0006468 | biological_process | protein phosphorylation |
| A | 0007165 | biological_process | signal transduction |
| A | 0007517 | biological_process | muscle organ development |
| A | 0016301 | molecular_function | kinase activity |
| A | 0016504 | molecular_function | peptidase activator activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0033554 | biological_process | cellular response to stress |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0042770 | biological_process | signal transduction in response to DNA damage |
| A | 0045445 | biological_process | myoblast differentiation |
| A | 0045786 | biological_process | negative regulation of cell cycle |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051149 | biological_process | positive regulation of muscle cell differentiation |
| A | 0051726 | biological_process | regulation of cell cycle |
| A | 0106310 | molecular_function | protein serine kinase activity |
| B | 0000165 | biological_process | MAPK cascade |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0000287 | molecular_function | magnesium ion binding |
| B | 0004672 | molecular_function | protein kinase activity |
| B | 0004674 | molecular_function | protein serine/threonine kinase activity |
| B | 0004707 | molecular_function | MAP kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0005654 | cellular_component | nucleoplasm |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006468 | biological_process | protein phosphorylation |
| B | 0007165 | biological_process | signal transduction |
| B | 0007517 | biological_process | muscle organ development |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016504 | molecular_function | peptidase activator activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0033554 | biological_process | cellular response to stress |
| B | 0035556 | biological_process | intracellular signal transduction |
| B | 0042770 | biological_process | signal transduction in response to DNA damage |
| B | 0045445 | biological_process | myoblast differentiation |
| B | 0045786 | biological_process | negative regulation of cell cycle |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0051149 | biological_process | positive regulation of muscle cell differentiation |
| B | 0051726 | biological_process | regulation of cell cycle |
| B | 0106310 | molecular_function | protein serine kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 401 |
| Chain | Residue |
| A | ASN158 |
| A | ASP171 |
| A | ANP400 |
| A | HOH2039 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG A 402 |
| Chain | Residue |
| A | ASP171 |
| A | ANP400 |
| A | HOH2152 |
| A | HOH2153 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1401 |
| Chain | Residue |
| B | ASP1171 |
| B | ANP1400 |
| B | ASN1158 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MG B 1402 |
| Chain | Residue |
| B | ASP1171 |
| B | ANP1400 |
| B | HOH2118 |
| site_id | AC5 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE ANP A 400 |
| Chain | Residue |
| A | VAL41 |
| A | ALA54 |
| A | LYS56 |
| A | ILE87 |
| A | MET109 |
| A | PRO110 |
| A | MET112 |
| A | ASP115 |
| A | LYS155 |
| A | GLY157 |
| A | ASN158 |
| A | LEU170 |
| A | ASP171 |
| A | MG401 |
| A | MG402 |
| A | HOH2039 |
| A | HOH2111 |
| A | HOH2152 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE ANP B 1400 |
| Chain | Residue |
| B | VAL1041 |
| B | ALA1054 |
| B | LYS1056 |
| B | ILE1087 |
| B | MET1109 |
| B | PRO1110 |
| B | MET1112 |
| B | ASP1115 |
| B | LYS1155 |
| B | GLY1157 |
| B | ASN1158 |
| B | LEU1170 |
| B | ASP1171 |
| B | MG1401 |
| B | MG1402 |
| B | HOH2002 |
| B | HOH2037 |
| B | HOH2053 |
| B | HOH2185 |
| B | HOH2186 |
Functional Information from PROSITE/UniProt
| site_id | PS00107 |
| Number of Residues | 25 |
| Details | PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. VGSGAYGAVCsAvdgrtgakv.........AIKK |
| Chain | Residue | Details |
| A | VAL33-LYS57 |
| site_id | PS01351 |
| Number of Residues | 104 |
| Details | MAPK MAP kinase signature. FqselfakrayRElrllkhmrhenviglldvftpdetlddftdfylvmpfmgtdlgklmkheklgedriqflvyqmlkglryihaagiih.........RDlKpgnlavnedC |
| Chain | Residue | Details |
| A | PHE62-CYS165 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | Motif: {"description":"TXY"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphothreonine; by MAP2K3 and MAP2K6","evidences":[{"source":"UniProtKB","id":"Q63538","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | GLY157 | |
| A | ASP153 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | GLY1157 | |
| B | ASP1153 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS155 | |
| A | ASP153 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS1155 | |
| B | ASP1153 |
| site_id | CSA5 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS155 | |
| A | THR188 | |
| A | ASP153 |
| site_id | CSA6 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | THR1188 | |
| B | LYS1155 | |
| B | ASP1153 |
| site_id | CSA7 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| A | LYS155 | |
| A | ASN158 | |
| A | ASP153 |
| site_id | CSA8 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ir3 |
| Chain | Residue | Details |
| B | LYS1155 | |
| B | ASN1158 | |
| B | ASP1153 |
