1CKM
STRUCTURE OF TWO DIFFERENT CONFORMATIONS OF MRNA CAPPING ENZYME IN COMPLEX WITH GTP
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| A | 0006397 | biological_process | mRNA processing |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016779 | molecular_function | nucleotidyltransferase activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004484 | molecular_function | mRNA guanylyltransferase activity |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0006139 | biological_process | nucleobase-containing compound metabolic process |
| B | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| B | 0006397 | biological_process | mRNA processing |
| B | 0016740 | molecular_function | transferase activity |
| B | 0016779 | molecular_function | nucleotidyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE GTP A 899 |
| Chain | Residue |
| A | PHE146 |
| A | LYS188 |
| A | TRP190 |
| A | ILE216 |
| A | LEU232 |
| A | LYS234 |
| A | HOH972 |
| A | HOH1043 |
| A | HOH1061 |
| A | HOH1062 |
| A | PRO59 |
| A | PRO61 |
| A | LYS82 |
| A | THR83 |
| A | ARG87 |
| A | ARG106 |
| A | GLU131 |
| site_id | AC2 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE GTP B 999 |
| Chain | Residue |
| B | PRO59 |
| B | LYS82 |
| B | THR83 |
| B | ARG87 |
| B | ARG106 |
| B | GLU131 |
| B | PHE146 |
| B | LYS188 |
| B | TRP190 |
| B | ILE216 |
| B | ARG228 |
| B | LYS234 |
| B | LYS236 |
| B | ASP244 |
| B | ARG295 |
| B | LYS298 |
| B | ASN302 |
| B | HOH1062 |
| B | HOH1105 |
| B | HOH1148 |
| B | HOH1149 |
| B | HOH1150 |
| B | HOH1155 |
| B | HOH1173 |
| B | HOH1175 |
| site_id | GPA |
| Number of Residues | 1 |
| Details | ACTIVE SITE LYSINE. |
| Chain | Residue |
| A | LYS82 |
| site_id | GPB |
| Number of Residues | 1 |
| Details | ACTIVE SITE LYSINE. |
| Chain | Residue |
| B | LYS82 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"N6-GMP-lysine intermediate"} |
| Chain | Residue | Details |
