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1CGH

Human cathepsin G

Functional Information from GO Data
ChainGOidnamespacecontents
A0002003biological_processangiotensin maturation
A0002548biological_processmonocyte chemotaxis
A0004252molecular_functionserine-type endopeptidase activity
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006468biological_processprotein phosphorylation
A0006508biological_processproteolysis
A0006935biological_processchemotaxis
A0006955biological_processimmune response
A0008201molecular_functionheparin binding
A0008233molecular_functionpeptidase activity
A0008236molecular_functionserine-type peptidase activity
A0010494cellular_componentcytoplasmic stress granule
A0016020cellular_componentmembrane
A0016485biological_processprotein processing
A0016787molecular_functionhydrolase activity
A0019221biological_processcytokine-mediated signaling pathway
A0019538biological_processprotein metabolic process
A0019731biological_processantibacterial humoral response
A0022617biological_processextracellular matrix disassembly
A0030141cellular_componentsecretory granule
A0030168biological_processplatelet activation
A0032496biological_processresponse to lipopolysaccharide
A0035578cellular_componentazurophil granule lumen
A0035590biological_processpurinergic nucleotide receptor signaling pathway
A0042119biological_processneutrophil activation
A0042742biological_processdefense response to bacterium
A0043231cellular_componentintracellular membrane-bounded organelle
A0048018molecular_functionreceptor ligand activity
A0050778biological_processpositive regulation of immune response
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0050832biological_processdefense response to fungus
A0050868biological_processnegative regulation of T cell activation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0070946biological_processneutrophil-mediated killing of gram-positive bacterium
A0071222biological_processcellular response to lipopolysaccharide
A0089720molecular_functioncaspase binding
A0098786biological_processbiofilm matrix disassembly
A1901731biological_processpositive regulation of platelet aggregation
Functional Information from PDB Data
site_idAC1
Number of Residues18
DetailsBINDING SITE FOR RESIDUE 1ZG A 1
ChainResidue
AHIS57
ASER214
ATYR215
AGLY216
ALYS217
AGLU226
AHOH324
AHOH379
AHOH388
AHOH389
APRO177
AARG178
AALA190
APHE191
ALYS192
AGLY193
AASP194
ASER195

Functional Information from PROSITE/UniProt
site_idPS00134
Number of Residues6
DetailsTRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC
ChainResidueDetails
ALEU53-CYS58

site_idPS00135
Number of Residues12
DetailsTRYPSIN_SER Serine proteases, trypsin family, serine active site. AAfkGDSGGPLL
ChainResidueDetails
AALA189-LEU200

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU00274
ChainResidueDetails
AHIS57
AASP102
ASER195

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (paucimannose) asparagine; alternate => ECO:0000269|PubMed:26274980
ChainResidueDetails
AASN65

218500

PDB entries from 2024-04-17

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