1CGH
Human cathepsin G
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002003 | biological_process | angiotensin maturation |
| A | 0002548 | biological_process | monocyte chemotaxis |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005764 | cellular_component | lysosome |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006935 | biological_process | chemotaxis |
| A | 0006955 | biological_process | immune response |
| A | 0008201 | molecular_function | heparin binding |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0010494 | cellular_component | cytoplasmic stress granule |
| A | 0016020 | cellular_component | membrane |
| A | 0016485 | biological_process | protein processing |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019221 | biological_process | cytokine-mediated signaling pathway |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0022617 | biological_process | extracellular matrix disassembly |
| A | 0030141 | cellular_component | secretory granule |
| A | 0030168 | biological_process | platelet activation |
| A | 0031012 | cellular_component | extracellular matrix |
| A | 0035578 | cellular_component | azurophil granule lumen |
| A | 0035590 | biological_process | purinergic nucleotide receptor signaling pathway |
| A | 0042119 | biological_process | neutrophil activation |
| A | 0042742 | biological_process | defense response to bacterium |
| A | 0048018 | molecular_function | receptor ligand activity |
| A | 0050829 | biological_process | defense response to Gram-negative bacterium |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0050868 | biological_process | negative regulation of T cell activation |
| A | 0051604 | biological_process | protein maturation |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071222 | biological_process | cellular response to lipopolysaccharide |
| A | 0089720 | molecular_function | caspase binding |
| A | 0098786 | biological_process | biofilm matrix disassembly |
| A | 1901731 | biological_process | positive regulation of platelet aggregation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE 1ZG A 1 |
| Chain | Residue |
| A | HIS57 |
| A | SER214 |
| A | TYR215 |
| A | GLY216 |
| A | LYS217 |
| A | GLU226 |
| A | HOH324 |
| A | HOH379 |
| A | HOH388 |
| A | HOH389 |
| A | PRO177 |
| A | ARG178 |
| A | ALA190 |
| A | PHE191 |
| A | LYS192 |
| A | GLY193 |
| A | ASP194 |
| A | SER195 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 222 |
| Details | Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Region: {"description":"Important for antimicrobial activity","evidences":[{"source":"PubMed","id":"2116408","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (paucimannose) asparagine; alternate","evidences":[{"source":"PubMed","id":"26274980","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | HIS57 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY196 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY193 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 |
| site_id | CSA5 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| A | GLY196 |
| site_id | CSA6 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 |
