1CEH
STRUCTURE AND FUNCTION OF THE CATALYTIC SITE MUTANT ASP99ASN OF PHOSPHOLIPASE A2: ABSENCE OF CONSERVED STRUCTURAL WATER
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0004623 | molecular_function | phospholipase A2 activity |
| A | 0005102 | molecular_function | signaling receptor binding |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005543 | molecular_function | phospholipid binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0006644 | biological_process | phospholipid metabolic process |
| A | 0008284 | biological_process | positive regulation of cell population proliferation |
| A | 0009986 | cellular_component | cell surface |
| A | 0016042 | biological_process | lipid catabolic process |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0032052 | molecular_function | bile acid binding |
| A | 0046470 | biological_process | phosphatidylcholine metabolic process |
| A | 0046471 | biological_process | phosphatidylglycerol metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0047498 | molecular_function | calcium-dependent phospholipase A2 activity |
| A | 0048146 | biological_process | positive regulation of fibroblast proliferation |
| A | 0050482 | biological_process | arachidonate secretion |
| A | 0050830 | biological_process | defense response to Gram-positive bacterium |
| A | 0061844 | biological_process | antimicrobial humoral immune response mediated by antimicrobial peptide |
| A | 1904635 | biological_process | positive regulation of podocyte apoptotic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 124 |
| Chain | Residue |
| A | TYR28 |
| A | GLY30 |
| A | GLY32 |
| A | ASP49 |
| A | HOH204 |
| A | HOH238 |
Functional Information from PROSITE/UniProt
| site_id | PS00118 |
| Number of Residues | 8 |
| Details | PA2_HIS Phospholipase A2 histidine active site. CCQtHDnC |
| Chain | Residue | Details |
| A | CYS44-CYS51 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"7464926","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10089353","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7265241","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9115986","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BP2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KVW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1MKS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1bp2 |
| Chain | Residue | Details |
| A | HIS48 | |
| A | GLY30 | |
| A | ASN99 |
