Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1CE8

CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005951	cellular_component	carbamoyl-phosphate synthase complex
A	0006221	biological_process	pyrimidine nucleotide biosynthetic process
A	0006526	biological_process	L-arginine biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0009064	biological_process	glutamine family amino acid metabolic process
A	0016597	molecular_function	amino acid binding
A	0016874	molecular_function	ligase activity
A	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
A	0019856	biological_process	pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0004359	molecular_function	glutaminase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005951	cellular_component	carbamoyl-phosphate synthase complex
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006221	biological_process	pyrimidine nucleotide biosynthetic process
B	0006526	biological_process	L-arginine biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016874	molecular_function	ligase activity
B	0019856	biological_process	pyrimidine nucleobase biosynthetic process
B	0044205	biological_process	'de novo' UMP biosynthetic process
B	0046982	molecular_function	protein heterodimerization activity
C	0000166	molecular_function	nucleotide binding
C	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
C	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005951	cellular_component	carbamoyl-phosphate synthase complex
C	0006221	biological_process	pyrimidine nucleotide biosynthetic process
C	0006526	biological_process	L-arginine biosynthetic process
C	0006541	biological_process	glutamine metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0009064	biological_process	glutamine family amino acid metabolic process
C	0016597	molecular_function	amino acid binding
C	0016874	molecular_function	ligase activity
C	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
C	0019856	biological_process	pyrimidine nucleobase biosynthetic process
C	0044205	biological_process	'de novo' UMP biosynthetic process
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D	0004359	molecular_function	glutaminase activity
D	0005515	molecular_function	protein binding
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005951	cellular_component	carbamoyl-phosphate synthase complex
D	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
D	0006221	biological_process	pyrimidine nucleotide biosynthetic process
D	0006526	biological_process	L-arginine biosynthetic process
D	0006541	biological_process	glutamine metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016874	molecular_function	ligase activity
D	0019856	biological_process	pyrimidine nucleobase biosynthetic process
D	0044205	biological_process	'de novo' UMP biosynthetic process
D	0046982	molecular_function	protein heterodimerization activity
E	0000166	molecular_function	nucleotide binding
E	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
E	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E	0005515	molecular_function	protein binding
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0005951	cellular_component	carbamoyl-phosphate synthase complex
E	0006221	biological_process	pyrimidine nucleotide biosynthetic process
E	0006526	biological_process	L-arginine biosynthetic process
E	0006541	biological_process	glutamine metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0009064	biological_process	glutamine family amino acid metabolic process
E	0016597	molecular_function	amino acid binding
E	0016874	molecular_function	ligase activity
E	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
E	0019856	biological_process	pyrimidine nucleobase biosynthetic process
E	0044205	biological_process	'de novo' UMP biosynthetic process
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F	0004359	molecular_function	glutaminase activity
F	0005515	molecular_function	protein binding
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0005951	cellular_component	carbamoyl-phosphate synthase complex
F	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
F	0006221	biological_process	pyrimidine nucleotide biosynthetic process
F	0006526	biological_process	L-arginine biosynthetic process
F	0006541	biological_process	glutamine metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016874	molecular_function	ligase activity
F	0019856	biological_process	pyrimidine nucleobase biosynthetic process
F	0044205	biological_process	'de novo' UMP biosynthetic process
F	0046982	molecular_function	protein heterodimerization activity
G	0000166	molecular_function	nucleotide binding
G	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
G	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G	0005515	molecular_function	protein binding
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0005829	cellular_component	cytosol
G	0005951	cellular_component	carbamoyl-phosphate synthase complex
G	0006221	biological_process	pyrimidine nucleotide biosynthetic process
G	0006526	biological_process	L-arginine biosynthetic process
G	0006541	biological_process	glutamine metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0009064	biological_process	glutamine family amino acid metabolic process
G	0016597	molecular_function	amino acid binding
G	0016874	molecular_function	ligase activity
G	0016879	molecular_function	ligase activity, forming carbon-nitrogen bonds
G	0019856	biological_process	pyrimidine nucleobase biosynthetic process
G	0044205	biological_process	'de novo' UMP biosynthetic process
G	0046872	molecular_function	metal ion binding
H	0000166	molecular_function	nucleotide binding
H	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H	0004359	molecular_function	glutaminase activity
H	0005515	molecular_function	protein binding
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0005829	cellular_component	cytosol
H	0005951	cellular_component	carbamoyl-phosphate synthase complex
H	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
H	0006221	biological_process	pyrimidine nucleotide biosynthetic process
H	0006526	biological_process	L-arginine biosynthetic process
H	0006541	biological_process	glutamine metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016874	molecular_function	ligase activity
H	0019856	biological_process	pyrimidine nucleobase biosynthetic process
H	0044205	biological_process	'de novo' UMP biosynthetic process
H	0046982	molecular_function	protein heterodimerization activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 5001

Chain	Residue
A	GLU299
A	ASN301
A	ADP5000
A	MN5002
A	PO45006
A	HOH5623

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 5002

Chain	Residue
A	MN5001
A	PO45006
A	HOH5611
A	GLN285
A	GLU299
A	ADP5000

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 5003

Chain	Residue
A	GLU215
A	ASN236
A	ASP238
A	ALA239
A	ILE242
A	SER247

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 5004

Chain	Residue
A	ALA126
A	GLU127
A	GLU299
A	MET300
A	ASN301
A	HOH5108

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 5005

Chain	Residue
A	GLU217
A	THR244
A	ASN283
A	GLN285
A	PO45006
A	HOH5225

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN A 5008

Chain	Residue
A	GLN829
A	GLU841
A	ADP5007

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 5009

Chain	Residue
A	GLU841
A	ASN843
A	ADP5007

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K A 5010

Chain	Residue
A	GLU761
A	HIS781
A	GLU783
A	GLN784
A	VAL787
A	SER792

site_id	AC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K A 5015

Chain	Residue
A	ASP84
A	GLY112
A	THR114

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL A 5016

Chain	Residue
A	GLN93
A	THR173
A	MET174
A	HOH5073

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 5017

Chain	Residue
A	ASN289
A	ASN292
A	ARG294

site_id	BC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CL A 5018

Chain	Residue
A	ALA370
A	ASN371
A	PHE900
A	PRO901
A	GLY902
A	HOH5582

site_id	BC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE K B 5019

Chain	Residue
B	HIS16
B	ASP112

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN C 5021

Chain	Residue
C	GLU299
C	ASN301
C	ADP5020
C	MN5022
C	PO45026
C	HOH5662

site_id	BC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN C 5022

Chain	Residue
C	GLN285
C	GLU299
C	ADP5020
C	MN5021
C	K5025
C	PO45026
C	HOH5629

site_id	BC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 5023

Chain	Residue
C	GLU215
C	ASN236
C	ASP238
C	ALA239
C	ILE242
C	SER247

site_id	BC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K C 5024

Chain	Residue
C	ALA126
C	GLU127
C	GLU299
C	MET300
C	ASN301
C	HOH5128
C	HOH5663

site_id	BC9
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K C 5025

Chain	Residue
C	GLU217
C	THR244
C	ASN283
C	GLN285
C	MN5022
C	PO45026
C	HOH5244

site_id	CC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN C 5028

Chain	Residue
C	GLN829
C	GLU841
C	ADP5027

site_id	CC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K C 5029

Chain	Residue
C	GLU841
C	ASN843
C	ADP5027

site_id	CC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K C 5030

Chain	Residue
C	GLU761
C	HIS781
C	GLU783
C	GLN784
C	VAL787
C	SER792

site_id	CC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K C 5035

Chain	Residue
C	ASP84
C	GLY112
C	THR114
C	HOH5043

site_id	CC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 5036

Chain	Residue
C	MET174

site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 5037

Chain	Residue
C	ASN289
C	ASN292
C	ARG294

site_id	CC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL C 5038

Chain	Residue
C	ALA370
C	ASN371
C	PHE900
C	PRO901
C	GLY902

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K D 5039

Chain	Residue
C	HOH5319
D	HIS16
D	ASP112
D	HOH1873

site_id	CC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN E 5041

Chain	Residue
E	GLU299
E	ASN301
E	ADP5040
E	MN5042
E	PO45046
E	HOH5686

site_id	DC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN E 5042

Chain	Residue
E	GLN285
E	GLU299
E	ADP5040
E	MN5041
E	K5045
E	PO45046
E	HOH5681

site_id	DC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 5043

Chain	Residue
E	GLU215
E	ASN236
E	ASP238
E	ALA239
E	ILE242
E	SER247

site_id	DC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 5044

Chain	Residue
E	ALA126
E	GLU127
E	GLU299
E	MET300
E	ASN301
E	HOH5153
E	HOH5686

site_id	DC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE K E 5045

Chain	Residue
E	GLU217
E	THR244
E	ASN283
E	GLN285
E	MN5042
E	PO45046
E	HOH5269

site_id	DC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE MN E 5048

Chain	Residue
E	SER789
E	GLN829
E	GLU841
E	ADP5047

site_id	DC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 5049

Chain	Residue
E	GLU841
E	ASN843
E	ADP5047

site_id	DC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K E 5050

Chain	Residue
E	GLU761
E	HIS781
E	GLU783
E	GLN784
E	VAL787
E	SER792

site_id	DC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K E 5055

Chain	Residue
E	ASP84
E	GLY112
E	THR114

site_id	DC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 5056

Chain	Residue
E	GLN93
E	THR173
E	MET174
E	HOH5098
E	HOH5118

site_id	EC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL E 5057

Chain	Residue
E	ASN289
E	ASN292
E	ARG294

site_id	EC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 5058

Chain	Residue
E	ALA370
E	ASN371
E	PHE900
E	PRO901
E	GLY902

site_id	EC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K F 5059

Chain	Residue
E	ARG490
E	HOH5341
F	HIS16
F	ASP112
F	HOH2962

site_id	EC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN G 5061

Chain	Residue
G	GLU299
G	ASN301
G	ADP5060
G	MN5062
G	PO45066
G	HOH5704

site_id	EC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN G 5062

Chain	Residue
G	HIS243
G	GLN285
G	GLU299
G	ADP5060
G	MN5061
G	PO45066
G	HOH5694

site_id	EC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 5063

Chain	Residue
G	GLU215
G	ASN236
G	ASP238
G	ALA239
G	ILE242
G	SER247

site_id	EC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 5064

Chain	Residue
G	ALA126
G	GLU127
G	GLU299
G	MET300
G	ASN301
G	HOH5182

site_id	EC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 5065

Chain	Residue
G	GLU217
G	THR244
G	ASN283
G	GLN285
G	PO45066
G	HOH5298

site_id	EC9
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MN G 5068

Chain	Residue
G	GLN829
G	GLU841
G	ADP5067

site_id	FC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K G 5069

Chain	Residue
G	GLU841
G	ASN843
G	ADP5067

site_id	FC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE K G 5070

Chain	Residue
G	GLU761
G	HIS781
G	GLU783
G	GLN784
G	VAL787
G	SER792

site_id	FC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE K G 5075

Chain	Residue
G	ASP84
G	GLY112
G	THR114
G	HOH5713

site_id	FC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 5076

Chain	Residue
G	GLN93
G	THR173
G	MET174

site_id	FC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL G 5077

Chain	Residue
G	ASN289
G	ASN292
G	ARG294

site_id	FC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL G 5078

Chain	Residue
G	ALA370
G	ASN371
G	PHE900
G	PRO901
G	GLY902

site_id	FC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE K H 5079

Chain	Residue
H	HIS16
H	ASP112
H	HOH3446

site_id	FC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 A 5006

Chain	Residue
A	MET174
A	GLY175
A	HIS243
A	GLN285
A	GLU299
A	ASN301
A	ARG303
A	ARG306
A	ADP5000
A	MN5001
A	MN5002
A	K5005
A	HOH5056
A	HOH5225

site_id	FC9
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PO4 C 5026

Chain	Residue
C	MET174
C	GLY175
C	HIS243
C	GLN285
C	GLU299
C	ASN301
C	ARG303
C	ARG306
C	ADP5020
C	MN5021
C	MN5022
C	K5025
C	HOH5076
C	HOH5244

site_id	GC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PO4 E 5046

Chain	Residue
E	MET174
E	GLY175
E	HIS243
E	GLN285
E	GLU299
E	ASN301
E	ARG303
E	ARG306
E	ADP5040
E	MN5041
E	MN5042
E	K5045

site_id	GC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PO4 G 5066

Chain	Residue
G	MET174
G	GLY175
G	HIS243
G	GLN285
G	GLU299
G	ASN301
G	ARG303
G	ARG306
G	ADP5060
G	MN5061
G	MN5062
G	K5065
G	HOH5130
G	HOH5298
G	HOH5694

site_id	GC3
Number of Residues	25
Details	BINDING SITE FOR RESIDUE ADP A 5000

Chain	Residue
A	ARG129
A	ILE167
A	ARG169
A	MET174
A	GLY175
A	GLY176
A	GLU208
A	LEU210
A	ILE211
A	GLU215
A	MET240
A	GLY241
A	ILE242
A	HIS243
A	THR244
A	GLN285
A	ILE298
A	GLU299
A	THR376
A	MN5001
A	MN5002
A	PO45006
A	HOH5445
A	HOH5611
A	HOH5623

site_id	GC4
Number of Residues	17
Details	BINDING SITE FOR RESIDUE ADP A 5007

Chain	Residue
A	PRO690
A	ARG715
A	HIS754
A	PHE755
A	LEU756
A	GLU761
A	ALA785
A	GLY786
A	VAL787
A	HIS788
A	SER789
A	GLN829
A	GLU841
A	MN5008
A	K5009
A	HOH5627
A	HOH5628

site_id	GC5
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ORN A 5011

Chain	Residue
A	GLU783
A	ASP791
A	GLU892
A	LEU907
A	TYR1040
A	ASP1041
A	THR1042
A	HOH5097
A	HOH5321

site_id	GC6
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IMP A 5012

Chain	Residue
A	SER948
A	VAL949
A	LYS954
A	THR974
A	GLY976
A	THR977
A	LYS993
A	VAL994
A	ILE1001
A	ASN1015
A	THR1016
A	THR1017
A	ASP1025
A	SER1026
A	VAL1028
A	HOH5379

site_id	GC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE NET A 5013

Chain	Residue
A	GLN22
A	THR94

site_id	GC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ORN A 5014

Chain	Residue
A	ARG528
A	ALA537
A	THR538
A	GLU552
A	ASN554
A	HOH5294
B	ARG120
B	ARG123

site_id	GC9
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP C 5020

Chain	Residue
C	ARG129
C	ILE167
C	ARG169
C	THR173
C	MET174
C	GLY175
C	GLY176
C	GLU208
C	LEU210
C	ILE211
C	GLU215
C	MET240
C	GLY241
C	ILE242
C	HIS243
C	THR244
C	GLN285
C	ILE298
C	GLU299
C	THR376
C	MN5021
C	MN5022
C	PO45026
C	HOH5462
C	HOH5629
C	HOH5662
C	HOH5762

site_id	HC1
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP C 5027

Chain	Residue
C	ARG715
C	HIS754
C	PHE755
C	LEU756
C	GLU761
C	ALA785
C	GLY786
C	VAL787
C	HIS788
C	SER789
C	GLN829
C	GLU841
C	MN5028
C	K5029

site_id	HC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN C 5031

Chain	Residue
C	GLU783
C	ASP791
C	GLU892
C	VAL893
C	LEU907
C	TYR1040
C	ASP1041
C	THR1042
C	HOH5117
C	HOH5339

site_id	HC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE IMP C 5032

Chain	Residue
C	SER948
C	VAL949
C	LYS954
C	THR974
C	GLY976
C	THR977
C	LYS993
C	VAL994
C	ILE1001
C	ASN1015
C	THR1016
C	THR1017
C	ASP1025
C	SER1026
C	VAL1028
C	HOH5398

site_id	HC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET C 5033

Chain	Residue
C	THR94
C	ASN97
C	ASN936
C	HOH5070

site_id	HC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ORN C 5034

Chain	Residue
C	ARG528
C	ALA537
C	THR538
C	GLU552
C	ASN554
C	HOH5689
C	HOH5713
D	ARG120
D	ARG123
D	HOH1337

site_id	HC6
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ADP E 5040

Chain	Residue
E	ARG129
E	ILE167
E	ARG169
E	THR173
E	MET174
E	GLY175
E	GLY176
E	GLU208
E	LEU210
E	ILE211
E	GLU215
E	MET240
E	GLY241
E	ILE242
E	HIS243
E	THR244
E	GLN285
E	ILE298
E	GLU299
E	THR376
E	MN5041
E	MN5042
E	PO45046
E	HOH5505
E	HOH5681
E	HOH5686
E	HOH5687

site_id	HC7
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP E 5047

Chain	Residue
E	ARG715
E	HIS754
E	PHE755
E	LEU756
E	GLU761
E	ALA785
E	GLY786
E	VAL787
E	HIS788
E	SER789
E	GLN829
E	GLU841
E	PRO909
E	MN5048
E	K5049

site_id	HC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN E 5051

Chain	Residue
E	GLU783
E	ASP791
E	GLU892
E	VAL893
E	LEU907
E	TYR1040
E	ASP1041
E	THR1042
E	HOH5142
E	HOH5361
E	HOH5697

site_id	HC9
Number of Residues	17
Details	BINDING SITE FOR RESIDUE IMP E 5052

Chain	Residue
E	SER948
E	LYS954
E	THR974
E	GLY976
E	THR977
E	LYS993
E	VAL994
E	ILE1001
E	ASN1015
E	THR1016
E	THR1017
E	ASP1025
E	SER1026
E	VAL1028
E	HOH5420
E	HOH5702
E	HOH5703

site_id	IC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE NET E 5053

Chain	Residue
E	GLN22
E	GLN93
E	THR94
E	ASN936

site_id	IC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ORN E 5054

Chain	Residue
E	ARG528
E	ALA537
E	THR538
E	GLU552
E	ASN554
E	HOH5333
E	HOH5785
E	HOH5789
E	HOH5880
F	ARG120
F	ARG123

site_id	IC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE ADP G 5060

Chain	Residue
G	ARG129
G	ILE167
G	ARG169
G	THR173
G	MET174
G	GLY175
G	GLY176
G	GLU208
G	LEU210
G	ILE211
G	GLU215
G	MET240
G	GLY241
G	ILE242
G	HIS243
G	THR244
G	GLN285
G	ILE298
G	GLU299
G	THR376
G	MN5061
G	MN5062
G	PO45066
G	HOH5513
G	HOH5694
G	HOH5704

site_id	IC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE ADP G 5067

Chain	Residue
G	ARG715
G	HIS754
G	PHE755
G	LEU756
G	GLU761
G	ALA785
G	GLY786
G	VAL787
G	HIS788
G	SER789
G	GLN829
G	GLU841
G	MN5068
G	K5069
G	HOH5707

site_id	IC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ORN G 5071

Chain	Residue
G	GLU783
G	ASP791
G	ALA793
G	GLU892
G	VAL893
G	LEU895
G	LEU907
G	TYR1040
G	ASP1041
G	THR1042
G	HOH5171
G	HOH5391

site_id	IC6
Number of Residues	15
Details	BINDING SITE FOR RESIDUE IMP G 5072

Chain	Residue
G	SER948
G	VAL949
G	LYS954
G	THR974
G	GLY976
G	THR977
G	LYS993
G	VAL994
G	ILE1001
G	ASN1015
G	THR1016
G	THR1017
G	ASP1025
G	SER1026
G	HOH5446

site_id	IC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NET G 5073

Chain	Residue
G	GLN22
G	GLN93
G	THR94
G	ASN97
G	HOH5125

site_id	IC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE ORN G 5074

Chain	Residue
G	ARG528
G	ALA537
G	THR538
G	GLU552
G	ASN554
H	ARG120
H	ARG123

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG

Chain	Residue	Details
A	PHE164-GLY178
A	TYR710-ALA724

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV

Chain	Residue	Details
A	VAL297-VAL304
A	LEU839-ALA846

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	780
Details	Domain: {"description":"ATP-grasp 1","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	544
Details	Domain: {"description":"MGS-like","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1604
Details	Region: {"description":"Carboxyphosphate synthetic domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	596
Details	Region: {"description":"Oligomerization domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	544
Details	Region: {"description":"Allosteric domain","evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	72
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A9X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C30","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CS0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1JDB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1KEE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1M6V","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T36","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10428826","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9636022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CE8","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01210","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10029528","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10089390","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	748
Details	Domain: {"description":"Glutamine amidotransferase type-1","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	8
Details	Active site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	32
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01209","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10587438","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1C3O","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269
F	GLU355

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	CYS269
H	GLU355

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	CYS269
B	GLU355

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	CYS269
D	GLU355

site_id	CSA5
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
B	HIS353
B	CYS269

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
D	HIS353
D	CYS269

site_id	CSA7
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
F	HIS353
F	CYS269

site_id	CSA8
Number of Residues	2
Details	Annotated By Reference To The Literature 1bxr

Chain	Residue	Details
H	HIS353
H	CYS269

site_id	MCSA1
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
B	CYS269	covalent catalysis, proton shuttle (general acid/base)
A	ARG303	electrostatic stabiliser
A	ARG715	electrostatic stabiliser
A	GLU761	steric role
A	GLN829	metal ligand
A	GLU841	metal ligand
A	ASN843	metal ligand
A	ARG848	electrostatic stabiliser
B	HIS353	proton shuttle (general acid/base)
B	GLU355	steric role
A	GLU215	steric role
A	HIS243	proton shuttle (general acid/base)
A	ASN283	electrostatic stabiliser
A	GLN285	metal ligand
A	GLU299	metal ligand
A	ASN301	metal ligand

site_id	MCSA2
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
D	CYS269	covalent catalysis, proton shuttle (general acid/base)
C	ARG303	electrostatic stabiliser
C	ARG715	electrostatic stabiliser
C	GLU761	steric role
C	GLN829	metal ligand
C	GLU841	metal ligand
C	ASN843	metal ligand
C	ARG848	electrostatic stabiliser
D	HIS353	proton shuttle (general acid/base)
D	GLU355	steric role
C	GLU215	steric role
C	HIS243	proton shuttle (general acid/base)
C	ASN283	electrostatic stabiliser
C	GLN285	metal ligand
C	GLU299	metal ligand
C	ASN301	metal ligand

site_id	MCSA3
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
F	CYS269	covalent catalysis, proton shuttle (general acid/base)
E	ARG303	electrostatic stabiliser
E	ARG715	electrostatic stabiliser
E	GLU761	steric role
E	GLN829	metal ligand
E	GLU841	metal ligand
E	ASN843	metal ligand
E	ARG848	electrostatic stabiliser
F	HIS353	proton shuttle (general acid/base)
F	GLU355	steric role
E	GLU215	steric role
E	HIS243	proton shuttle (general acid/base)
E	ASN283	electrostatic stabiliser
E	GLN285	metal ligand
E	GLU299	metal ligand
E	ASN301	metal ligand

site_id	MCSA4
Number of Residues	3
Details	M-CSA 435

Chain	Residue	Details
H	CYS269	covalent catalysis, proton shuttle (general acid/base)
G	ARG303	electrostatic stabiliser
G	ARG715	electrostatic stabiliser
G	GLU761	steric role
G	GLN829	metal ligand
G	GLU841	metal ligand
G	ASN843	metal ligand
G	ARG848	electrostatic stabiliser
H	HIS353	proton shuttle (general acid/base)
H	GLU355	steric role
G	GLU215	steric role
G	HIS243	proton shuttle (general acid/base)
G	ASN283	electrostatic stabiliser
G	GLN285	metal ligand
G	GLU299	metal ligand
G	ASN301	metal ligand

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)