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1CE8

CARBAMOYL PHOSPHATE SYNTHETASE FROM ESCHERICHIS COLI WITH COMPLEXED WITH THE ALLOSTERIC LIGAND IMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0004070molecular_functionaspartate carbamoyltransferase activity
A0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
A0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0004151molecular_functiondihydroorotase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005951cellular_componentcarbamoyl-phosphate synthase complex
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006221biological_processpyrimidine nucleotide biosynthetic process
A0006228biological_processUTP biosynthetic process
A0006526biological_processarginine biosynthetic process
A0006541biological_processglutamine metabolic process
A0006807biological_processnitrogen compound metabolic process
A0008652biological_processamino acid biosynthetic process
A0016597molecular_functionamino acid binding
A0016874molecular_functionligase activity
A0019240biological_processcitrulline biosynthetic process
A0019856biological_processpyrimidine nucleobase biosynthetic process
A0044205biological_process'de novo' UMP biosynthetic process
A0046872molecular_functionmetal ion binding
B0000166molecular_functionnucleotide binding
B0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B0004359molecular_functionglutaminase activity
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005951cellular_componentcarbamoyl-phosphate synthase complex
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006221biological_processpyrimidine nucleotide biosynthetic process
B0006526biological_processarginine biosynthetic process
B0006541biological_processglutamine metabolic process
B0008652biological_processamino acid biosynthetic process
B0016874molecular_functionligase activity
B0019856biological_processpyrimidine nucleobase biosynthetic process
B0044205biological_process'de novo' UMP biosynthetic process
B0046982molecular_functionprotein heterodimerization activity
C0000166molecular_functionnucleotide binding
C0004070molecular_functionaspartate carbamoyltransferase activity
C0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
C0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
C0004151molecular_functiondihydroorotase activity
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0005951cellular_componentcarbamoyl-phosphate synthase complex
C0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
C0006221biological_processpyrimidine nucleotide biosynthetic process
C0006228biological_processUTP biosynthetic process
C0006526biological_processarginine biosynthetic process
C0006541biological_processglutamine metabolic process
C0006807biological_processnitrogen compound metabolic process
C0008652biological_processamino acid biosynthetic process
C0016597molecular_functionamino acid binding
C0016874molecular_functionligase activity
C0019240biological_processcitrulline biosynthetic process
C0019856biological_processpyrimidine nucleobase biosynthetic process
C0044205biological_process'de novo' UMP biosynthetic process
C0046872molecular_functionmetal ion binding
D0000166molecular_functionnucleotide binding
D0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
D0004359molecular_functionglutaminase activity
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0005951cellular_componentcarbamoyl-phosphate synthase complex
D0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
D0006221biological_processpyrimidine nucleotide biosynthetic process
D0006526biological_processarginine biosynthetic process
D0006541biological_processglutamine metabolic process
D0008652biological_processamino acid biosynthetic process
D0016874molecular_functionligase activity
D0019856biological_processpyrimidine nucleobase biosynthetic process
D0044205biological_process'de novo' UMP biosynthetic process
D0046982molecular_functionprotein heterodimerization activity
E0000166molecular_functionnucleotide binding
E0004070molecular_functionaspartate carbamoyltransferase activity
E0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
E0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
E0004151molecular_functiondihydroorotase activity
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005951cellular_componentcarbamoyl-phosphate synthase complex
E0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
E0006221biological_processpyrimidine nucleotide biosynthetic process
E0006228biological_processUTP biosynthetic process
E0006526biological_processarginine biosynthetic process
E0006541biological_processglutamine metabolic process
E0006807biological_processnitrogen compound metabolic process
E0008652biological_processamino acid biosynthetic process
E0016597molecular_functionamino acid binding
E0016874molecular_functionligase activity
E0019240biological_processcitrulline biosynthetic process
E0019856biological_processpyrimidine nucleobase biosynthetic process
E0044205biological_process'de novo' UMP biosynthetic process
E0046872molecular_functionmetal ion binding
F0000166molecular_functionnucleotide binding
F0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
F0004359molecular_functionglutaminase activity
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005951cellular_componentcarbamoyl-phosphate synthase complex
F0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
F0006221biological_processpyrimidine nucleotide biosynthetic process
F0006526biological_processarginine biosynthetic process
F0006541biological_processglutamine metabolic process
F0008652biological_processamino acid biosynthetic process
F0016874molecular_functionligase activity
F0019856biological_processpyrimidine nucleobase biosynthetic process
F0044205biological_process'de novo' UMP biosynthetic process
F0046982molecular_functionprotein heterodimerization activity
G0000166molecular_functionnucleotide binding
G0004070molecular_functionaspartate carbamoyltransferase activity
G0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
G0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
G0004151molecular_functiondihydroorotase activity
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0005829cellular_componentcytosol
G0005951cellular_componentcarbamoyl-phosphate synthase complex
G0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
G0006221biological_processpyrimidine nucleotide biosynthetic process
G0006228biological_processUTP biosynthetic process
G0006526biological_processarginine biosynthetic process
G0006541biological_processglutamine metabolic process
G0006807biological_processnitrogen compound metabolic process
G0008652biological_processamino acid biosynthetic process
G0016597molecular_functionamino acid binding
G0016874molecular_functionligase activity
G0019240biological_processcitrulline biosynthetic process
G0019856biological_processpyrimidine nucleobase biosynthetic process
G0044205biological_process'de novo' UMP biosynthetic process
G0046872molecular_functionmetal ion binding
H0000166molecular_functionnucleotide binding
H0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
H0004359molecular_functionglutaminase activity
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0005829cellular_componentcytosol
H0005951cellular_componentcarbamoyl-phosphate synthase complex
H0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
H0006221biological_processpyrimidine nucleotide biosynthetic process
H0006526biological_processarginine biosynthetic process
H0006541biological_processglutamine metabolic process
H0008652biological_processamino acid biosynthetic process
H0016874molecular_functionligase activity
H0019856biological_processpyrimidine nucleobase biosynthetic process
H0044205biological_process'de novo' UMP biosynthetic process
H0046982molecular_functionprotein heterodimerization activity
Functional Information from PDB Data
site_idAC1
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 5001
ChainResidue
AGLU299
AASN301
AADP5000
AMN5002
APO45006
AHOH5623

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN A 5002
ChainResidue
AMN5001
APO45006
AHOH5611
AGLN285
AGLU299
AADP5000

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 5003
ChainResidue
AGLU215
AASN236
AASP238
AALA239
AILE242
ASER247

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 5004
ChainResidue
AALA126
AGLU127
AGLU299
AMET300
AASN301
AHOH5108

site_idAC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 5005
ChainResidue
AGLU217
ATHR244
AASN283
AGLN285
APO45006
AHOH5225

site_idAC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN A 5008
ChainResidue
AGLN829
AGLU841
AADP5007

site_idAC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K A 5009
ChainResidue
AGLU841
AASN843
AADP5007

site_idAC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K A 5010
ChainResidue
AGLU761
AHIS781
AGLU783
AGLN784
AVAL787
ASER792

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K A 5015
ChainResidue
AASP84
AGLY112
ATHR114

site_idBC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE CL A 5016
ChainResidue
AGLN93
ATHR173
AMET174
AHOH5073

site_idBC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL A 5017
ChainResidue
AASN289
AASN292
AARG294

site_idBC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CL A 5018
ChainResidue
AALA370
AASN371
APHE900
APRO901
AGLY902
AHOH5582

site_idBC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE K B 5019
ChainResidue
BHIS16
BASP112

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN C 5021
ChainResidue
CGLU299
CASN301
CADP5020
CMN5022
CPO45026
CHOH5662

site_idBC6
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN C 5022
ChainResidue
CGLN285
CGLU299
CADP5020
CMN5021
CK5025
CPO45026
CHOH5629

site_idBC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K C 5023
ChainResidue
CGLU215
CASN236
CASP238
CALA239
CILE242
CSER247

site_idBC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K C 5024
ChainResidue
CALA126
CGLU127
CGLU299
CMET300
CASN301
CHOH5128
CHOH5663

site_idBC9
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K C 5025
ChainResidue
CGLU217
CTHR244
CASN283
CGLN285
CMN5022
CPO45026
CHOH5244

site_idCC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN C 5028
ChainResidue
CGLN829
CGLU841
CADP5027

site_idCC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K C 5029
ChainResidue
CGLU841
CASN843
CADP5027

site_idCC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K C 5030
ChainResidue
CGLU761
CHIS781
CGLU783
CGLN784
CVAL787
CSER792

site_idCC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K C 5035
ChainResidue
CASP84
CGLY112
CTHR114
CHOH5043

site_idCC5
Number of Residues1
DetailsBINDING SITE FOR RESIDUE CL C 5036
ChainResidue
CMET174

site_idCC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL C 5037
ChainResidue
CASN289
CASN292
CARG294

site_idCC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL C 5038
ChainResidue
CALA370
CASN371
CPHE900
CPRO901
CGLY902

site_idCC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K D 5039
ChainResidue
CHOH5319
DHIS16
DASP112
DHOH1873

site_idCC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN E 5041
ChainResidue
EGLU299
EASN301
EADP5040
EMN5042
EPO45046
EHOH5686

site_idDC1
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN E 5042
ChainResidue
EGLN285
EGLU299
EADP5040
EMN5041
EK5045
EPO45046
EHOH5681

site_idDC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K E 5043
ChainResidue
EGLU215
EASN236
EASP238
EALA239
EILE242
ESER247

site_idDC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K E 5044
ChainResidue
EALA126
EGLU127
EGLU299
EMET300
EASN301
EHOH5153
EHOH5686

site_idDC4
Number of Residues7
DetailsBINDING SITE FOR RESIDUE K E 5045
ChainResidue
EGLU217
ETHR244
EASN283
EGLN285
EMN5042
EPO45046
EHOH5269

site_idDC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MN E 5048
ChainResidue
ESER789
EGLN829
EGLU841
EADP5047

site_idDC6
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K E 5049
ChainResidue
EGLU841
EASN843
EADP5047

site_idDC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K E 5050
ChainResidue
EGLU761
EHIS781
EGLU783
EGLN784
EVAL787
ESER792

site_idDC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K E 5055
ChainResidue
EASP84
EGLY112
ETHR114

site_idDC9
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL E 5056
ChainResidue
EGLN93
ETHR173
EMET174
EHOH5098
EHOH5118

site_idEC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL E 5057
ChainResidue
EASN289
EASN292
EARG294

site_idEC2
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL E 5058
ChainResidue
EALA370
EASN371
EPHE900
EPRO901
EGLY902

site_idEC3
Number of Residues5
DetailsBINDING SITE FOR RESIDUE K F 5059
ChainResidue
EARG490
EHOH5341
FHIS16
FASP112
FHOH2962

site_idEC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE MN G 5061
ChainResidue
GGLU299
GASN301
GADP5060
GMN5062
GPO45066
GHOH5704

site_idEC5
Number of Residues7
DetailsBINDING SITE FOR RESIDUE MN G 5062
ChainResidue
GHIS243
GGLN285
GGLU299
GADP5060
GMN5061
GPO45066
GHOH5694

site_idEC6
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K G 5063
ChainResidue
GGLU215
GASN236
GASP238
GALA239
GILE242
GSER247

site_idEC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K G 5064
ChainResidue
GALA126
GGLU127
GGLU299
GMET300
GASN301
GHOH5182

site_idEC8
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K G 5065
ChainResidue
GGLU217
GTHR244
GASN283
GGLN285
GPO45066
GHOH5298

site_idEC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MN G 5068
ChainResidue
GGLN829
GGLU841
GADP5067

site_idFC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K G 5069
ChainResidue
GGLU841
GASN843
GADP5067

site_idFC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE K G 5070
ChainResidue
GGLU761
GHIS781
GGLU783
GGLN784
GVAL787
GSER792

site_idFC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE K G 5075
ChainResidue
GASP84
GGLY112
GTHR114
GHOH5713

site_idFC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL G 5076
ChainResidue
GGLN93
GTHR173
GMET174

site_idFC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE CL G 5077
ChainResidue
GASN289
GASN292
GARG294

site_idFC6
Number of Residues5
DetailsBINDING SITE FOR RESIDUE CL G 5078
ChainResidue
GALA370
GASN371
GPHE900
GPRO901
GGLY902

site_idFC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE K H 5079
ChainResidue
HHIS16
HASP112
HHOH3446

site_idFC8
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PO4 A 5006
ChainResidue
AMET174
AGLY175
AHIS243
AGLN285
AGLU299
AASN301
AARG303
AARG306
AADP5000
AMN5001
AMN5002
AK5005
AHOH5056
AHOH5225

site_idFC9
Number of Residues14
DetailsBINDING SITE FOR RESIDUE PO4 C 5026
ChainResidue
CMET174
CGLY175
CHIS243
CGLN285
CGLU299
CASN301
CARG303
CARG306
CADP5020
CMN5021
CMN5022
CK5025
CHOH5076
CHOH5244

site_idGC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE PO4 E 5046
ChainResidue
EMET174
EGLY175
EHIS243
EGLN285
EGLU299
EASN301
EARG303
EARG306
EADP5040
EMN5041
EMN5042
EK5045

site_idGC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE PO4 G 5066
ChainResidue
GMET174
GGLY175
GHIS243
GGLN285
GGLU299
GASN301
GARG303
GARG306
GADP5060
GMN5061
GMN5062
GK5065
GHOH5130
GHOH5298
GHOH5694

site_idGC3
Number of Residues25
DetailsBINDING SITE FOR RESIDUE ADP A 5000
ChainResidue
AARG129
AILE167
AARG169
AMET174
AGLY175
AGLY176
AGLU208
ALEU210
AILE211
AGLU215
AMET240
AGLY241
AILE242
AHIS243
ATHR244
AGLN285
AILE298
AGLU299
ATHR376
AMN5001
AMN5002
APO45006
AHOH5445
AHOH5611
AHOH5623

site_idGC4
Number of Residues17
DetailsBINDING SITE FOR RESIDUE ADP A 5007
ChainResidue
APRO690
AARG715
AHIS754
APHE755
ALEU756
AGLU761
AALA785
AGLY786
AVAL787
AHIS788
ASER789
AGLN829
AGLU841
AMN5008
AK5009
AHOH5627
AHOH5628

site_idGC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ORN A 5011
ChainResidue
AGLU783
AASP791
AGLU892
ALEU907
ATYR1040
AASP1041
ATHR1042
AHOH5097
AHOH5321

site_idGC6
Number of Residues16
DetailsBINDING SITE FOR RESIDUE IMP A 5012
ChainResidue
ASER948
AVAL949
ALYS954
ATHR974
AGLY976
ATHR977
ALYS993
AVAL994
AILE1001
AASN1015
ATHR1016
ATHR1017
AASP1025
ASER1026
AVAL1028
AHOH5379

site_idGC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE NET A 5013
ChainResidue
AGLN22
ATHR94

site_idGC8
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ORN A 5014
ChainResidue
AARG528
AALA537
ATHR538
AGLU552
AASN554
AHOH5294
BARG120
BARG123

site_idGC9
Number of Residues27
DetailsBINDING SITE FOR RESIDUE ADP C 5020
ChainResidue
CARG129
CILE167
CARG169
CTHR173
CMET174
CGLY175
CGLY176
CGLU208
CLEU210
CILE211
CGLU215
CMET240
CGLY241
CILE242
CHIS243
CTHR244
CGLN285
CILE298
CGLU299
CTHR376
CMN5021
CMN5022
CPO45026
CHOH5462
CHOH5629
CHOH5662
CHOH5762

site_idHC1
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP C 5027
ChainResidue
CARG715
CHIS754
CPHE755
CLEU756
CGLU761
CALA785
CGLY786
CVAL787
CHIS788
CSER789
CGLN829
CGLU841
CMN5028
CK5029

site_idHC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ORN C 5031
ChainResidue
CGLU783
CASP791
CGLU892
CVAL893
CLEU907
CTYR1040
CASP1041
CTHR1042
CHOH5117
CHOH5339

site_idHC3
Number of Residues16
DetailsBINDING SITE FOR RESIDUE IMP C 5032
ChainResidue
CSER948
CVAL949
CLYS954
CTHR974
CGLY976
CTHR977
CLYS993
CVAL994
CILE1001
CASN1015
CTHR1016
CTHR1017
CASP1025
CSER1026
CVAL1028
CHOH5398

site_idHC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NET C 5033
ChainResidue
CTHR94
CASN97
CASN936
CHOH5070

site_idHC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ORN C 5034
ChainResidue
CARG528
CALA537
CTHR538
CGLU552
CASN554
CHOH5689
CHOH5713
DARG120
DARG123
DHOH1337

site_idHC6
Number of Residues27
DetailsBINDING SITE FOR RESIDUE ADP E 5040
ChainResidue
EARG129
EILE167
EARG169
ETHR173
EMET174
EGLY175
EGLY176
EGLU208
ELEU210
EILE211
EGLU215
EMET240
EGLY241
EILE242
EHIS243
ETHR244
EGLN285
EILE298
EGLU299
ETHR376
EMN5041
EMN5042
EPO45046
EHOH5505
EHOH5681
EHOH5686
EHOH5687

site_idHC7
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ADP E 5047
ChainResidue
EARG715
EHIS754
EPHE755
ELEU756
EGLU761
EALA785
EGLY786
EVAL787
EHIS788
ESER789
EGLN829
EGLU841
EPRO909
EMN5048
EK5049

site_idHC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ORN E 5051
ChainResidue
EGLU783
EASP791
EGLU892
EVAL893
ELEU907
ETYR1040
EASP1041
ETHR1042
EHOH5142
EHOH5361
EHOH5697

site_idHC9
Number of Residues17
DetailsBINDING SITE FOR RESIDUE IMP E 5052
ChainResidue
ESER948
ELYS954
ETHR974
EGLY976
ETHR977
ELYS993
EVAL994
EILE1001
EASN1015
ETHR1016
ETHR1017
EASP1025
ESER1026
EVAL1028
EHOH5420
EHOH5702
EHOH5703

site_idIC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE NET E 5053
ChainResidue
EGLN22
EGLN93
ETHR94
EASN936

site_idIC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ORN E 5054
ChainResidue
EARG528
EALA537
ETHR538
EGLU552
EASN554
EHOH5333
EHOH5785
EHOH5789
EHOH5880
FARG120
FARG123

site_idIC3
Number of Residues26
DetailsBINDING SITE FOR RESIDUE ADP G 5060
ChainResidue
GARG129
GILE167
GARG169
GTHR173
GMET174
GGLY175
GGLY176
GGLU208
GLEU210
GILE211
GGLU215
GMET240
GGLY241
GILE242
GHIS243
GTHR244
GGLN285
GILE298
GGLU299
GTHR376
GMN5061
GMN5062
GPO45066
GHOH5513
GHOH5694
GHOH5704

site_idIC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ADP G 5067
ChainResidue
GARG715
GHIS754
GPHE755
GLEU756
GGLU761
GALA785
GGLY786
GVAL787
GHIS788
GSER789
GGLN829
GGLU841
GMN5068
GK5069
GHOH5707

site_idIC5
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ORN G 5071
ChainResidue
GGLU783
GASP791
GALA793
GGLU892
GVAL893
GLEU895
GLEU907
GTYR1040
GASP1041
GTHR1042
GHOH5171
GHOH5391

site_idIC6
Number of Residues15
DetailsBINDING SITE FOR RESIDUE IMP G 5072
ChainResidue
GSER948
GVAL949
GLYS954
GTHR974
GGLY976
GTHR977
GLYS993
GVAL994
GILE1001
GASN1015
GTHR1016
GTHR1017
GASP1025
GSER1026
GHOH5446

site_idIC7
Number of Residues5
DetailsBINDING SITE FOR RESIDUE NET G 5073
ChainResidue
GGLN22
GGLN93
GTHR94
GASN97
GHOH5125

site_idIC8
Number of Residues7
DetailsBINDING SITE FOR RESIDUE ORN G 5074
ChainResidue
GARG528
GALA537
GTHR538
GGLU552
GASN554
HARG120
HARG123

Functional Information from PROSITE/UniProt
site_idPS00866
Number of Residues15
DetailsCPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. FPCIIRPSftmGGsG
ChainResidueDetails
APHE164-GLY178
ATYR710-ALA724

site_idPS00867
Number of Residues8
DetailsCPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. VIEMNPRV
ChainResidueDetails
AVAL297-VAL304
ALEU839-ALA846

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_01209
ChainResidueDetails
BLEU270
AHIS243
AARG715
AHIS754
ALEU756
AGLU761
AGLY786
AVAL787
AHIS788
ASER789
CARG129
DLEU270
CARG169
CGLY175
CGLY176
CGLU208
CLEU210
CGLU215
CGLY241
CILE242
CHIS243
CARG715
FLEU270
CHIS754
CLEU756
CGLU761
CGLY786
CVAL787
CHIS788
CSER789
EARG129
EARG169
EGLY175
HLEU270
EGLY176
EGLU208
ELEU210
EGLU215
EGLY241
EILE242
EHIS243
EARG715
EHIS754
ELEU756
AGLU208
EGLU761
EGLY786
EVAL787
EHIS788
ESER789
GARG129
GARG169
GGLY175
GGLY176
GGLU208
ALEU210
GLEU210
GGLU215
GGLY241
GILE242
GHIS243
GARG715
GHIS754
GLEU756
GGLU761
GGLY786
AGLU215
GVAL787
GHIS788
GSER789
AGLY241
AILE242

site_idSWS_FT_FI2
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000255|HAMAP-Rule:MF_01209
ChainResidueDetails
BPRO354
BALA356
DPRO354
DALA356
FPRO354
FALA356
HPRO354
HALA356

site_idSWS_FT_FI3
Number of Residues32
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01209, ECO:0000269|PubMed:10587438, ECO:0007744|PDB:1C3O
ChainResidueDetails
BTYR48
DPRO242
DASP244
DGLY271
DLEU274
DHIS312
DPHE314
DALA315
FTYR48
FPRO242
FASP244
BPRO242
FGLY271
FLEU274
FHIS312
FPHE314
FALA315
HTYR48
HPRO242
HASP244
HGLY271
HLEU274
BASP244
HHIS312
HPHE314
HALA315
BGLY271
BLEU274
BHIS312
BPHE314
BALA315
DTYR48

site_idSWS_FT_FI4
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8
ChainResidueDetails
AGLN829
CGLN829
EGLN829
GGLN829

site_idSWS_FT_FI5
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390, ECO:0000269|PubMed:10428826, ECO:0000269|PubMed:9636022, ECO:0007744|PDB:1CE8
ChainResidueDetails
AGLU841
CGLU841
EGLU841
GGLU841

site_idSWS_FT_FI6
Number of Residues4
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01210, ECO:0000269|PubMed:10029528, ECO:0000269|PubMed:10089390
ChainResidueDetails
AASN843
CASN843
EASN843
GASN843

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
BLEU270covalent catalysis, proton shuttle (general acid/base)
AARG303electrostatic stabiliser
AARG715electrostatic stabiliser
AGLY721electrostatic stabiliser
AGLY722electrostatic stabiliser
AGLU761steric role
AGLN829metal ligand
AGLU841metal ligand
AASN843metal ligand
AARG848electrostatic stabiliser
BPRO354proton shuttle (general acid/base)
BALA356steric role
AGLU215steric role
AHIS243proton shuttle (general acid/base)
AASN283electrostatic stabiliser
AGLN285metal ligand
AGLU299metal ligand
AASN301metal ligand

site_idMCSA2
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
DLEU270covalent catalysis, proton shuttle (general acid/base)
CARG303electrostatic stabiliser
CARG715electrostatic stabiliser
CGLY721electrostatic stabiliser
CGLY722electrostatic stabiliser
CGLU761steric role
CGLN829metal ligand
CGLU841metal ligand
CASN843metal ligand
CARG848electrostatic stabiliser
DPRO354proton shuttle (general acid/base)
DALA356steric role
CGLU215steric role
CHIS243proton shuttle (general acid/base)
CASN283electrostatic stabiliser
CGLN285metal ligand
CGLU299metal ligand
CASN301metal ligand

site_idMCSA3
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
FLEU270covalent catalysis, proton shuttle (general acid/base)
EARG303electrostatic stabiliser
EARG715electrostatic stabiliser
EGLY721electrostatic stabiliser
EGLY722electrostatic stabiliser
EGLU761steric role
EGLN829metal ligand
EGLU841metal ligand
EASN843metal ligand
EARG848electrostatic stabiliser
FPRO354proton shuttle (general acid/base)
FALA356steric role
EGLU215steric role
EHIS243proton shuttle (general acid/base)
EASN283electrostatic stabiliser
EGLN285metal ligand
EGLU299metal ligand
EASN301metal ligand

site_idMCSA4
Number of Residues3
DetailsM-CSA 435
ChainResidueDetails
HLEU270covalent catalysis, proton shuttle (general acid/base)
GARG303electrostatic stabiliser
GARG715electrostatic stabiliser
GGLY721electrostatic stabiliser
GGLY722electrostatic stabiliser
GGLU761steric role
GGLN829metal ligand
GGLU841metal ligand
GASN843metal ligand
GARG848electrostatic stabiliser
HPRO354proton shuttle (general acid/base)
HALA356steric role
GGLU215steric role
GHIS243proton shuttle (general acid/base)
GASN283electrostatic stabiliser
GGLN285metal ligand
GGLU299metal ligand
GASN301metal ligand

217705

PDB entries from 2024-03-27

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