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1CC0

CRYSTAL STRUCTURE OF THE RHOA.GDP-RHOGDI COMPLEX

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000902biological_processcell morphogenesis
A0001764biological_processneuron migration
A0001822biological_processkidney development
A0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
A0002363biological_processalpha-beta T cell lineage commitment
A0003100biological_processregulation of systemic arterial blood pressure by endothelin
A0003189biological_processaortic valve formation
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0005938cellular_componentcell cortex
A0006357biological_processregulation of transcription by RNA polymerase II
A0007010biological_processcytoskeleton organization
A0007049biological_processcell cycle
A0007155biological_processcell adhesion
A0007160biological_processcell-matrix adhesion
A0007264biological_processsmall GTPase-mediated signal transduction
A0007266biological_processRho protein signal transduction
A0007519biological_processskeletal muscle tissue development
A0009898cellular_componentcytoplasmic side of plasma membrane
A0010812biological_processnegative regulation of cell-substrate adhesion
A0010975biological_processregulation of neuron projection development
A0016020cellular_componentmembrane
A0016477biological_processcell migration
A0016787molecular_functionhydrolase activity
A0017022molecular_functionmyosin binding
A0019901molecular_functionprotein kinase binding
A0021762biological_processsubstantia nigra development
A0021795biological_processcerebral cortex cell migration
A0021861biological_processforebrain radial glial cell differentiation
A0030027cellular_componentlamellipodium
A0030036biological_processactin cytoskeleton organization
A0030054cellular_componentcell junction
A0030154biological_processcell differentiation
A0030334biological_processregulation of cell migration
A0030425cellular_componentdendrite
A0030496cellular_componentmidbody
A0030521biological_processandrogen receptor signaling pathway
A0030667cellular_componentsecretory granule membrane
A0031122biological_processcytoplasmic microtubule organization
A0031982cellular_componentvesicle
A0032154cellular_componentcleavage furrow
A0032467biological_processpositive regulation of cytokinesis
A0032587cellular_componentruffle membrane
A0032956biological_processregulation of actin cytoskeleton organization
A0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
A0033688biological_processregulation of osteoblast proliferation
A0034329biological_processcell junction assembly
A0034446biological_processsubstrate adhesion-dependent cell spreading
A0035385biological_processRoundabout signaling pathway
A0036089biological_processcleavage furrow formation
A0038027biological_processapolipoprotein A-I-mediated signaling pathway
A0042476biological_processodontogenesis
A0042995cellular_componentcell projection
A0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
A0043149biological_processstress fiber assembly
A0043197cellular_componentdendritic spine
A0043296cellular_componentapical junction complex
A0043297biological_processapical junction assembly
A0043366biological_processbeta selection
A0043542biological_processendothelial cell migration
A0043931biological_processossification involved in bone maturation
A0044319biological_processwound healing, spreading of cells
A0045198biological_processestablishment of epithelial cell apical/basal polarity
A0045666biological_processpositive regulation of neuron differentiation
A0045792biological_processnegative regulation of cell size
A0046638biological_processpositive regulation of alpha-beta T cell differentiation
A0050919biological_processnegative chemotaxis
A0051301biological_processcell division
A0051496biological_processpositive regulation of stress fiber assembly
A0051893biological_processregulation of focal adhesion assembly
A0060071biological_processWnt signaling pathway, planar cell polarity pathway
A0060193biological_processpositive regulation of lipase activity
A0061430biological_processbone trabecula morphogenesis
A0070062cellular_componentextracellular exosome
A0070507biological_processregulation of microtubule cytoskeleton organization
A0071222biological_processcellular response to lipopolysaccharide
A0071345biological_processcellular response to cytokine stimulus
A0071526biological_processsemaphorin-plexin signaling pathway
A0071803biological_processpositive regulation of podosome assembly
A0071902biological_processpositive regulation of protein serine/threonine kinase activity
A0071944cellular_componentcell periphery
A0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
A0090307biological_processmitotic spindle assembly
A0090324biological_processnegative regulation of oxidative phosphorylation
A0097049biological_processmotor neuron apoptotic process
A0097498biological_processendothelial tube lumen extension
A0098794cellular_componentpostsynapse
A0098978cellular_componentglutamatergic synapse
A0099159biological_processregulation of modification of postsynaptic structure
A0101003cellular_componentficolin-1-rich granule membrane
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1902766biological_processskeletal muscle satellite cell migration
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903673biological_processmitotic cleavage furrow formation
A1904695biological_processpositive regulation of vascular associated smooth muscle contraction
A1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
A1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
A1990869biological_processcellular response to chemokine
A2000177biological_processregulation of neural precursor cell proliferation
A2000406biological_processpositive regulation of T cell migration
A2000672biological_processnegative regulation of motor neuron apoptotic process
C0000166molecular_functionnucleotide binding
C0000902biological_processcell morphogenesis
C0001764biological_processneuron migration
C0001822biological_processkidney development
C0001998biological_processangiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure
C0002363biological_processalpha-beta T cell lineage commitment
C0003100biological_processregulation of systemic arterial blood pressure by endothelin
C0003189biological_processaortic valve formation
C0003924molecular_functionGTPase activity
C0003925molecular_functionG protein activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005737cellular_componentcytoplasm
C0005768cellular_componentendosome
C0005789cellular_componentendoplasmic reticulum membrane
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0005938cellular_componentcell cortex
C0006357biological_processregulation of transcription by RNA polymerase II
C0007010biological_processcytoskeleton organization
C0007049biological_processcell cycle
C0007155biological_processcell adhesion
C0007160biological_processcell-matrix adhesion
C0007264biological_processsmall GTPase-mediated signal transduction
C0007266biological_processRho protein signal transduction
C0007519biological_processskeletal muscle tissue development
C0009898cellular_componentcytoplasmic side of plasma membrane
C0010812biological_processnegative regulation of cell-substrate adhesion
C0010975biological_processregulation of neuron projection development
C0016020cellular_componentmembrane
C0016477biological_processcell migration
C0016787molecular_functionhydrolase activity
C0017022molecular_functionmyosin binding
C0019901molecular_functionprotein kinase binding
C0021762biological_processsubstantia nigra development
C0021795biological_processcerebral cortex cell migration
C0021861biological_processforebrain radial glial cell differentiation
C0030027cellular_componentlamellipodium
C0030036biological_processactin cytoskeleton organization
C0030054cellular_componentcell junction
C0030154biological_processcell differentiation
C0030334biological_processregulation of cell migration
C0030425cellular_componentdendrite
C0030496cellular_componentmidbody
C0030521biological_processandrogen receptor signaling pathway
C0030667cellular_componentsecretory granule membrane
C0031122biological_processcytoplasmic microtubule organization
C0031982cellular_componentvesicle
C0032154cellular_componentcleavage furrow
C0032467biological_processpositive regulation of cytokinesis
C0032587cellular_componentruffle membrane
C0032956biological_processregulation of actin cytoskeleton organization
C0033144biological_processnegative regulation of intracellular steroid hormone receptor signaling pathway
C0033688biological_processregulation of osteoblast proliferation
C0034329biological_processcell junction assembly
C0034446biological_processsubstrate adhesion-dependent cell spreading
C0035385biological_processRoundabout signaling pathway
C0036089biological_processcleavage furrow formation
C0038027biological_processapolipoprotein A-I-mediated signaling pathway
C0042476biological_processodontogenesis
C0042995cellular_componentcell projection
C0043123biological_processpositive regulation of canonical NF-kappaB signal transduction
C0043149biological_processstress fiber assembly
C0043197cellular_componentdendritic spine
C0043296cellular_componentapical junction complex
C0043297biological_processapical junction assembly
C0043366biological_processbeta selection
C0043542biological_processendothelial cell migration
C0043931biological_processossification involved in bone maturation
C0044319biological_processwound healing, spreading of cells
C0045198biological_processestablishment of epithelial cell apical/basal polarity
C0045666biological_processpositive regulation of neuron differentiation
C0045792biological_processnegative regulation of cell size
C0046638biological_processpositive regulation of alpha-beta T cell differentiation
C0050919biological_processnegative chemotaxis
C0051301biological_processcell division
C0051496biological_processpositive regulation of stress fiber assembly
C0051893biological_processregulation of focal adhesion assembly
C0060071biological_processWnt signaling pathway, planar cell polarity pathway
C0060193biological_processpositive regulation of lipase activity
C0061430biological_processbone trabecula morphogenesis
C0070062cellular_componentextracellular exosome
C0070507biological_processregulation of microtubule cytoskeleton organization
C0071222biological_processcellular response to lipopolysaccharide
C0071345biological_processcellular response to cytokine stimulus
C0071526biological_processsemaphorin-plexin signaling pathway
C0071803biological_processpositive regulation of podosome assembly
C0071902biological_processpositive regulation of protein serine/threonine kinase activity
C0071944cellular_componentcell periphery
C0090051biological_processnegative regulation of cell migration involved in sprouting angiogenesis
C0090307biological_processmitotic spindle assembly
C0090324biological_processnegative regulation of oxidative phosphorylation
C0097049biological_processmotor neuron apoptotic process
C0097498biological_processendothelial tube lumen extension
C0098794cellular_componentpostsynapse
C0098978cellular_componentglutamatergic synapse
C0099159biological_processregulation of modification of postsynaptic structure
C0101003cellular_componentficolin-1-rich granule membrane
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1902766biological_processskeletal muscle satellite cell migration
C1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
C1903673biological_processmitotic cleavage furrow formation
C1904695biological_processpositive regulation of vascular associated smooth muscle contraction
C1904996biological_processpositive regulation of leukocyte adhesion to vascular endothelial cell
C1905274biological_processregulation of modification of postsynaptic actin cytoskeleton
C1990869biological_processcellular response to chemokine
C2000177biological_processregulation of neural precursor cell proliferation
C2000406biological_processpositive regulation of T cell migration
C2000672biological_processnegative regulation of motor neuron apoptotic process
E0001772cellular_componentimmunological synapse
E0005094molecular_functionRho GDP-dissociation inhibitor activity
E0005096molecular_functionGTPase activator activity
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005737cellular_componentcytoplasm
E0005829cellular_componentcytosol
E0005856cellular_componentcytoskeleton
E0007266biological_processRho protein signal transduction
E0016020cellular_componentmembrane
E0032880biological_processregulation of protein localization
E0035023biological_processregulation of Rho protein signal transduction
E0043066biological_processnegative regulation of apoptotic process
E0070062cellular_componentextracellular exosome
E0071526biological_processsemaphorin-plexin signaling pathway
E0098685cellular_componentSchaffer collateral - CA1 synapse
E0098693biological_processregulation of synaptic vesicle cycle
F0001772cellular_componentimmunological synapse
F0005094molecular_functionRho GDP-dissociation inhibitor activity
F0005096molecular_functionGTPase activator activity
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005737cellular_componentcytoplasm
F0005829cellular_componentcytosol
F0005856cellular_componentcytoskeleton
F0007266biological_processRho protein signal transduction
F0016020cellular_componentmembrane
F0032880biological_processregulation of protein localization
F0035023biological_processregulation of Rho protein signal transduction
F0043066biological_processnegative regulation of apoptotic process
F0070062cellular_componentextracellular exosome
F0071526biological_processsemaphorin-plexin signaling pathway
F0098685cellular_componentSchaffer collateral - CA1 synapse
F0098693biological_processregulation of synaptic vesicle cycle
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 301
ChainResidue
ATHR19
ATHR37
AGDP201

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 302
ChainResidue
CTHR19
CTHR37
CGDP202

site_idAC3
Number of Residues15
DetailsBINDING SITE FOR RESIDUE GDP A 201
ChainResidue
AGLY17
ALYS18
ATHR19
ACYS20
APHE30
ALYS118
AASP120
ALEU121
ASER160
AALA161
ALYS162
AMG301
AGLY14
AALA15
ACYS16

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE GDP C 202
ChainResidue
CGLY14
CALA15
CCYS16
CGLY17
CLYS18
CTHR19
CCYS20
CPHE30
CLYS118
CASP120
CLEU121
CSER160
CALA161
CLYS162
CMG302

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:20068231
ChainResidueDetails
EALA2
FALA2
CGLY12
CASN117

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q99PT1
ChainResidueDetails
ESER34
FSER34
ASER160
CPHE30
CASP59
CSER160

site_idSWS_FT_FI3
Number of Residues2
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99PT1
ChainResidueDetails
ELYS43
FLYS43

site_idSWS_FT_FI4
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ESER47
FSER47

site_idSWS_FT_FI5
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ELYS105
ELYS127
ELYS178
FLYS105
FLYS127
FLYS178

site_idSWS_FT_FI6
Number of Residues2
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q99PT1
ChainResidueDetails
ELYS141
FLYS141

site_idSWS_FT_FI7
Number of Residues6
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211
ChainResidueDetails
ELYS138
CGLN63
ELYS141
FLYS138
FLYS141

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; by PKG/PRKG1 => ECO:0000269|PubMed:11162591
ChainResidueDetails
ASER188
CSER188

site_idSWS_FT_FI9
Number of Residues2
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
ACYS190
CCYS190

site_idSWS_FT_FI10
Number of Residues6
DetailsLIPID: (Microbial infection) N6-stearoyl lysine => ECO:0000269|PubMed:30061757
ChainResidueDetails
ALYS185
ALYS186
ALYS187
CLYS185
CLYS186
CLYS187

site_idSWS_FT_FI11
Number of Residues2
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250|UniProtKB:P61585
ChainResidueDetails
ACYS190
CCYS190

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230; alternate => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR34
CTYR34

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB; alternate => ECO:0000269|PubMed:24905543, ECO:0000269|PubMed:7775453, ECO:0000269|PubMed:7777059
ChainResidueDetails
ATHR37
CTHR37

site_idSWS_FT_FI14
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:23871831
ChainResidueDetails
ALYS135
CLYS135

218853

PDB entries from 2024-04-24

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