1CBY

DELTA-ENDOTOXIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005576	cellular_component	extracellular region

Functional Information from PDB Data

site_id	CPS
Number of Residues	1
Details	C-TERMINAL PROTEOLYTIC PROCESSING STOP. SEE REMARK FOR THE NPS SITE ABOVE.

Chain	Residue
A	SER228

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site_id	NPS
Number of Residues	1
Details	N-TERMINAL PROTEOLYTIC PROCESSING STOP. THE COORDINATES OF CYTB IS THAT OF THE INACTIVE PROTOXIN, WHICH EXISTS AS A DIMER IN THE CRYSTAL AND IN SOLUTION. THE N-TERMINAL ARMS OF TWO MONOMERS ARE INTERTWINED IN FORMING THE CENTRAL PAIR OF STRANDS IN A 12-STRANDED SHEET OF THE DIMER. PROTEOLYTIC PROCESSING CLEAVES THIS PAIR OF STRANDS TO RELEASE THE ACTIVE TOXIN AS A MONOMER, WHICH EXTENDS FROM THE NPS SITE TO THE CPS SITE WHEN PROTEINASE K IS USED FOR THE PROCESSING.

Chain	Residue
A	SER38

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