1C5F

CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A

Replaces:  1QTL

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0006457	biological_process	protein folding
C	0000413	biological_process	protein peptidyl-prolyl isomerization
C	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
C	0006457	biological_process	protein folding
E	0000413	biological_process	protein peptidyl-prolyl isomerization
E	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
E	0006457	biological_process	protein folding
G	0000413	biological_process	protein peptidyl-prolyl isomerization
G	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
G	0006457	biological_process	protein folding
I	0000413	biological_process	protein peptidyl-prolyl isomerization
I	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
I	0006457	biological_process	protein folding
K	0000413	biological_process	protein peptidyl-prolyl isomerization
K	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
K	0006457	biological_process	protein folding
M	0000413	biological_process	protein peptidyl-prolyl isomerization
M	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
M	0006457	biological_process	protein folding
O	0000413	biological_process	protein peptidyl-prolyl isomerization
O	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
O	0006457	biological_process	protein folding

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR CHAIN B OF CYCLOSPORIN A

Chain	Residue
A	ARG66
A	HIS132
A	HIS137
B	HOH2001
A	PHE71
A	GLN74
A	GLY83
A	ALA112
A	ASN113
A	LYS114
A	GLN122
A	PHE124

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR CHAIN D OF CYCLOSPORIN A

Chain	Residue
C	ARG66
C	PHE71
C	GLN74
C	GLY83
C	ALA112
C	ASN113
C	LYS114
C	GLN122
C	PHE124
C	HIS132
C	HIS137
C	HOH2023
D	HOH2001
D	HOH2003

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR CHAIN F OF CYCLOSPORIN A

Chain	Residue
E	ARG66
E	PHE71
E	GLN74
E	GLY83
E	ALA112
E	ASN113
E	LYS114
E	GLN122
E	PHE124
E	HIS132
E	HIS137
F	HOH2001

---

site_id	AC4
Number of Residues	19
Details	BINDING SITE FOR CHAIN H OF CYCLOSPORIN A

Chain	Residue
E	MET46
E	ALA47
E	ILE89
E	HOH2016
G	ARG66
G	PHE71
G	GLN74
G	GLY83
G	ALA112
G	ASN113
G	LYS114
G	GLN122
G	PHE124
G	HIS132
G	HIS137
H	HOH2001
H	HOH2002
O	HIS132
O	ILE136

---

site_id	AC5
Number of Residues	12
Details	BINDING SITE FOR CHAIN J OF CYCLOSPORIN A

Chain	Residue
I	ARG66
I	PHE71
I	GLN74
I	GLY83
I	ALA112
I	ASN113
I	LYS114
I	GLN122
I	PHE124
I	HIS132
I	HIS137
J	HOH2002

---

site_id	AC6
Number of Residues	19
Details	BINDING SITE FOR CHAIN L OF CYCLOSPORIN A

Chain	Residue
C	MET46
C	ALA47
C	ILE89
K	ARG66
K	PHE71
K	GLN74
K	GLY83
K	ALA112
K	ASN113
K	LYS114
K	GLN122
K	PHE124
K	HIS132
K	HIS137
K	HOH2038
L	HOH2002
L	HOH2003
M	HIS132
M	ILE136

---

site_id	AC7
Number of Residues	15
Details	BINDING SITE FOR CHAIN N OF CYCLOSPORIN A

Chain	Residue
M	PHE124
M	HIS132
M	HIS137
N	HOH2001
C	ARG34
K	HIS132
K	ILE136
M	ARG66
M	PHE71
M	GLN74
M	GLY83
M	ALA112
M	ASN113
M	LYS114
M	GLN122

---

site_id	AC8
Number of Residues	14
Details	BINDING SITE FOR CHAIN P OF CYCLOSPORIN A

Chain	Residue
E	ARG34
E	TYR90
G	HIS132
O	ARG66
O	PHE71
O	GLN74
O	GLY83
O	ALA112
O	ASN113
O	LYS114
O	GLN122
O	PHE124
O	HIS132
O	HIS137

---

Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YkgStFHRVIknFMiQGG

Chain	Residue	Details
A	TYR59-GLY76

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1320
Details	Domain: {"description":"PPIase cyclophilin-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00156","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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