1C1Y

CRYSTAL STRUCTURE OF RAP.GMPPNP IN COMPLEX WITH THE RAS-BINDING-DOMAIN OF C-RAF1 KINASE (RAFRBD).

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005085	molecular_function	guanyl-nucleotide exchange factor activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005768	cellular_component	endosome
A	0005769	cellular_component	early endosome
A	0005770	cellular_component	late endosome
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0007165	biological_process	signal transduction
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0007399	biological_process	nervous system development
A	0010008	cellular_component	endosome membrane
A	0010976	biological_process	positive regulation of neuron projection development
A	0016020	cellular_component	membrane
A	0016079	biological_process	synaptic vesicle exocytosis
A	0016787	molecular_function	hydrolase activity
A	0019003	molecular_function	GDP binding
A	0030033	biological_process	microvillus assembly
A	0030054	cellular_component	cell junction
A	0031267	molecular_function	small GTPase binding
A	0032045	cellular_component	guanyl-nucleotide exchange factor complex
A	0032486	biological_process	Rap protein signal transduction
A	0035579	cellular_component	specific granule membrane
A	0038180	biological_process	nerve growth factor signaling pathway
A	0043005	cellular_component	neuron projection
A	0043547	biological_process	positive regulation of GTPase activity
A	0044877	molecular_function	protein-containing complex binding
A	0045860	biological_process	positive regulation of protein kinase activity
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0061028	biological_process	establishment of endothelial barrier
A	0070062	cellular_component	extracellular exosome
A	0070161	cellular_component	anchoring junction
A	0070374	biological_process	positive regulation of ERK1 and ERK2 cascade
A	0071320	biological_process	cellular response to cAMP
A	0072659	biological_process	protein localization to plasma membrane
A	0097225	cellular_component	sperm midpiece
A	0098696	biological_process	regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
A	0098793	cellular_component	presynapse
A	0098978	cellular_component	glutamatergic synapse
A	1901888	biological_process	regulation of cell junction assembly
A	1990090	biological_process	cellular response to nerve growth factor stimulus
A	2000301	biological_process	negative regulation of synaptic vesicle exocytosis
A	2001214	biological_process	positive regulation of vasculogenesis
B	0007165	biological_process	signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 171

Chain	Residue
A	SER17
A	THR35
A	GTP170
A	HOH401
A	HOH402

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 173

Chain	Residue
B	HOH413
B	HOH420
B	ASP80
B	GLY123
B	GLU125
B	HOH405

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site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GTP A 170

Chain	Residue
A	GLY12
A	GLY13
A	VAL14
A	GLY15
A	LYS16
A	SER17
A	ALA18
A	PHE28
A	VAL29
A	GLU30
A	TYR32
A	PRO34
A	THR35
A	GLY60
A	ASN116
A	LYS117
A	ASP119
A	SER147
A	ALA148
A	LYS149
A	MG171
A	HOH401
A	HOH402
A	HOH412
A	HOH432
A	HOH471

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:7791872, ECO:0000269|PubMed:8756332

Chain	Residue	Details
A	GLY10
A	VAL29
A	GLY60
A	ASN116

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	THR61

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