1BSP
THERMOSTABLE THYMIDYLATE SYNTHASE A FROM BACILLUS SUBTILIS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| B | 0004799 | molecular_function | thymidylate synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0006231 | biological_process | dTMP biosynthetic process |
| B | 0006235 | biological_process | dTTP biosynthetic process |
| B | 0008168 | molecular_function | methyltransferase activity |
| B | 0009165 | biological_process | nucleotide biosynthetic process |
| B | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| B | 0032259 | biological_process | methylation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 300 |
| Chain | Residue |
| A | ARG181 |
| B | ARG141 |
| B | ARG142 |
| B | HOH306 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 301 |
| Chain | Residue |
| B | SER182 |
| A | ARG141 |
| A | ARG142 |
| B | ARG181 |
| site_id | CTA |
| Number of Residues | 1 |
| Details | CATALYTIC CYSTEINE. |
| Chain | Residue |
| A | CYS161 |
| site_id | CTB |
| Number of Residues | 1 |
| Details | CATALYTIC CYSTEINE. |
| Chain | Residue |
| B | CYS161 |
Functional Information from PROSITE/UniProt
| site_id | PS00091 |
| Number of Residues | 29 |
| Details | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RrhItmlWNpdeldama.....LtPCVyetQWyV |
| Chain | Residue | Details |
| A | ARG141-VAL169 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008 |
| Chain | Residue | Details |
| A | CYS161 | |
| B | CYS161 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00008 |
| Chain | Residue | Details |
| A | ARG141 | |
| A | ASP184 | |
| A | ALA278 | |
| B | ARG141 | |
| B | ASP184 | |
| B | ALA278 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_00008 |
| Chain | Residue | Details |
| A | ARG181 | |
| A | ASN192 | |
| A | HIS222 | |
| B | ARG181 | |
| B | ASN192 | |
| B | HIS222 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b02 |
| Chain | Residue | Details |
| A | SER182 | |
| A | GLU71 | |
| A | HIS222 | |
| A | CYS161 | |
| A | ASP220 | |
| A | ASP184 |
| site_id | CSA2 |
| Number of Residues | 6 |
| Details | Annotated By Reference To The Literature 1b02 |
| Chain | Residue | Details |
| B | SER182 | |
| B | GLU71 | |
| B | HIS222 | |
| B | CYS161 | |
| B | ASP220 | |
| B | ASP184 |
| site_id | CSA3 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b02 |
| Chain | Residue | Details |
| A | ASN192 | |
| A | GLN195 | |
| A | CYS161 |
| site_id | CSA4 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1b02 |
| Chain | Residue | Details |
| B | ASN192 | |
| B | GLN195 | |
| B | CYS161 |
