1BOB

HISTONE ACETYLTRANSFERASE HAT1 FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH ACETYL COENZYME A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004402	molecular_function	histone acetyltransferase activity
A	0005634	cellular_component	nucleus
A	0006325	biological_process	chromatin organization
A	0016747	molecular_function	acyltransferase activity, transferring groups other than amino-acyl groups
A	0031509	biological_process	subtelomeric heterochromatin formation
A	0042393	molecular_function	histone binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 321

Chain	Residue
A	GLU255
A	ASP256
A	ASP256
A	HOH460

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site_id	AC2
Number of Residues	27
Details	BINDING SITE FOR RESIDUE ACO A 400

Chain	Residue
A	LYS182
A	SER218
A	GLN219
A	PHE220
A	LEU221
A	ILE222
A	GLN227
A	ASN228
A	LYS229
A	GLY230
A	HIS231
A	GLY232
A	SER233
A	VAL254
A	GLU255
A	ASN258
A	PHE261
A	LEU264
A	ARG267
A	HOH401
A	HOH403
A	HOH417
A	LYS123
A	VAL124
A	SER125
A	GLU126
A	ILE161

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000303|PubMed:24835250

Chain	Residue	Details
A	GLU255

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site_id	SWS_FT_FI2
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:24835250, ECO:0000269|PubMed:9727486

Chain	Residue	Details
A	PHE220
A	GLN227
A	ASN258

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:9727486

Chain	Residue	Details
A	ARG267

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site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Interaction with histone H4 N-terminus => ECO:0000269|PubMed:24835250

Chain	Residue	Details
A	TRP174

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 224

Chain	Residue	Details
A	PHE220	electrostatic stabiliser, hydrogen bond donor
A	GLU255	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

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