1BJ4

RECOMBINANT SERINE HYDROXYMETHYLTRANSFERASE (HUMAN)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000900	molecular_function	mRNA regulatory element binding translation repressor activity
A	0004372	molecular_function	glycine hydroxymethyltransferase activity
A	0004793	molecular_function	threonine aldolase activity
A	0005515	molecular_function	protein binding
A	0005521	molecular_function	lamin binding
A	0005634	cellular_component	nucleus
A	0005657	cellular_component	replication fork
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006231	biological_process	dTMP biosynthetic process
A	0006260	biological_process	DNA replication
A	0006417	biological_process	regulation of translation
A	0006544	biological_process	glycine metabolic process
A	0006563	biological_process	L-serine metabolic process
A	0006565	biological_process	L-serine catabolic process
A	0006730	biological_process	one-carbon metabolic process
A	0008732	molecular_function	L-allo-threonine aldolase activity
A	0009113	biological_process	purine nucleobase biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016829	molecular_function	lyase activity
A	0016832	molecular_function	aldehyde-lyase activity
A	0017148	biological_process	negative regulation of translation
A	0019264	biological_process	glycine biosynthetic process from serine
A	0030170	molecular_function	pyridoxal phosphate binding
A	0035999	biological_process	tetrahydrofolate interconversion
A	0036094	molecular_function	small molecule binding
A	0042802	molecular_function	identical protein binding
A	0042803	molecular_function	protein homodimerization activity
A	0045329	biological_process	carnitine biosynthetic process
A	0046653	biological_process	tetrahydrofolate metabolic process
A	0046655	biological_process	folic acid metabolic process
A	0048027	molecular_function	mRNA 5'-UTR binding
A	0050179	molecular_function	phenylserine aldolase activity
A	0051289	biological_process	protein homotetramerization
A	0070013	cellular_component	intracellular organelle lumen
A	0070062	cellular_component	extracellular exosome
A	0070905	molecular_function	serine binding
A	0120567	molecular_function	hydroxytrimethyllysine aldolase activity
A	1904482	biological_process	cellular response to tetrahydrofolate

Functional Information from PROSITE/UniProt

site_id	PS00096
Number of Residues	17
Details	SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVvTTTTHKTLrGCRAG

Chain	Residue	Details
A	HIS249-GLY265

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	Modified residue: {"description":"N6-(pyridoxal phosphate)lysine","evidences":[{"source":"PubMed","id":"9753690","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BJ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1dfo

Chain	Residue	Details
A	ARG81

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site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1dfo

Chain	Residue	Details
A	GLU75
A	THR254
A	LYS257

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