1BIY
STRUCTURE OF DIFERRIC BUFFALO LACTOFERRIN
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001503 | biological_process | ossification |
| A | 0001817 | biological_process | regulation of cytokine production |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0002376 | biological_process | immune system process |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005769 | cellular_component | early endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0019732 | biological_process | antifungal humoral response |
| A | 0031665 | biological_process | negative regulation of lipopolysaccharide-mediated signaling pathway |
| A | 0032680 | biological_process | regulation of tumor necrosis factor production |
| A | 0033690 | biological_process | positive regulation of osteoblast proliferation |
| A | 0042581 | cellular_component | specific granule |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045669 | biological_process | positive regulation of osteoblast differentiation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0060349 | biological_process | bone morphogenesis |
| A | 1900159 | biological_process | positive regulation of bone mineralization involved in bone maturation |
| A | 1900229 | biological_process | negative regulation of single-species biofilm formation in or on host organism |
| A | 1902732 | biological_process | positive regulation of chondrocyte proliferation |
| A | 2000308 | biological_process | negative regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| A | 2001205 | biological_process | negative regulation of osteoclast development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE A 690 |
| Chain | Residue |
| A | ASP60 |
| A | TYR92 |
| A | TYR192 |
| A | HIS253 |
| A | CO3692 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE A 691 |
| Chain | Residue |
| A | ASP395 |
| A | TYR433 |
| A | TYR526 |
| A | HIS595 |
| A | CO3693 |
| site_id | AC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE CO3 A 692 |
| Chain | Residue |
| A | ASP60 |
| A | TYR92 |
| A | THR117 |
| A | ARG121 |
| A | ALA123 |
| A | GLY124 |
| A | TYR192 |
| A | HIS253 |
| A | FE690 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE CO3 A 693 |
| Chain | Residue |
| A | ASP395 |
| A | TYR433 |
| A | THR459 |
| A | ARG463 |
| A | THR464 |
| A | ALA465 |
| A | GLY466 |
| A | TYR526 |
| A | HIS595 |
| A | FE691 |
| site_id | FE1 |
| Number of Residues | 5 |
| Details | IRON BINDING SITE IN N-LOBE. |
| Chain | Residue |
| A | ASP60 |
| A | TYR92 |
| A | TYR192 |
| A | HIS253 |
| A | CO3692 |
| site_id | FE2 |
| Number of Residues | 5 |
| Details | IRON BINDING SITE IN C-LOBE. |
| Chain | Residue |
| A | CO3693 |
| A | ASP395 |
| A | TYR433 |
| A | TYR526 |
| A | HIS595 |
Functional Information from PROSITE/UniProt
| site_id | PS00205 |
| Number of Residues | 10 |
| Details | TRANSFERRIN_LIKE_1 Transferrin-like domain signature 1. YyAVAVVKKG |
| Chain | Residue | Details |
| A | TYR92-GLY101 | |
| A | TYR433-ALA442 |
| site_id | PS00206 |
| Number of Residues | 17 |
| Details | TRANSFERRIN_LIKE_2 Transferrin-like domain signature 2. YsGAFKCLqdgaGDVAF |
| Chain | Residue | Details |
| A | TYR192-PHE208 | |
| A | TYR526-PHE542 |
| site_id | PS00207 |
| Number of Residues | 31 |
| Details | TRANSFERRIN_LIKE_3 Transferrin-like domain signature 3. QYeLLClNntrap...VdafkeChlAqvpsHaVV |
| Chain | Residue | Details |
| A | GLN226-VAL256 | |
| A | ASP568-VAL598 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00741 |
| Chain | Residue | Details |
| A | LYS73 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000255|PROSITE-ProRule:PRU00741 |
| Chain | Residue | Details |
| A | SER259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:10531476, ECO:0000269|PubMed:10818344, ECO:0007744|PDB:1BIY, ECO:0007744|PDB:1CE2 |
| Chain | Residue | Details |
| A | ASP60 | |
| A | TYR92 | |
| A | HIS253 | |
| A | ASP395 | |
| A | TYR433 | |
| A | TYR526 | |
| A | HIS595 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00741, ECO:0000269|PubMed:10531476, ECO:0000269|PubMed:10818344 |
| Chain | Residue | Details |
| A | THR117 | |
| A | ARG121 | |
| A | ALA123 | |
| A | GLY124 | |
| A | THR459 | |
| A | ARG463 | |
| A | ALA465 | |
| A | GLY466 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1BIY, ECO:0007744|PDB:1CE2 |
| Chain | Residue | Details |
| A | TYR192 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) (high mannose) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|DOI:10.1016/j.idairyj.2021.105215 |
| Chain | Residue | Details |
| A | ASN233 | |
| A | ASN545 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|DOI:10.1016/j.idairyj.2021.105215 |
| Chain | Residue | Details |
| A | ASN281 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) (hybrid) asparagine; alternate => ECO:0000255|PROSITE-ProRule:PRU00498, ECO:0000269|DOI:10.1016/j.idairyj.2021.105215 |
| Chain | Residue | Details |
| A | ASN476 |
