Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1BIY

STRUCTURE OF DIFERRIC BUFFALO LACTOFERRIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001503	biological_process	ossification
A	0001817	biological_process	regulation of cytokine production
A	0002227	biological_process	innate immune response in mucosa
A	0002376	biological_process	immune system process
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005769	cellular_component	early endosome
A	0005886	cellular_component	plasma membrane
A	0006508	biological_process	proteolysis
A	0006811	biological_process	monoatomic ion transport
A	0006826	biological_process	iron ion transport
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0019731	biological_process	antibacterial humoral response
A	0019732	biological_process	antifungal humoral response
A	0031665	biological_process	negative regulation of lipopolysaccharide-mediated signaling pathway
A	0032680	biological_process	regulation of tumor necrosis factor production
A	0033690	biological_process	positive regulation of osteoblast proliferation
A	0042581	cellular_component	specific granule
A	0043066	biological_process	negative regulation of apoptotic process
A	0045669	biological_process	positive regulation of osteoblast differentiation
A	0046872	molecular_function	metal ion binding
A	0051241	biological_process	negative regulation of multicellular organismal process
A	0055037	cellular_component	recycling endosome
A	0060349	biological_process	bone morphogenesis
A	1900159	biological_process	positive regulation of bone mineralization involved in bone maturation
A	1900229	biological_process	negative regulation of single-species biofilm formation in or on host organism
A	1902732	biological_process	positive regulation of chondrocyte proliferation
A	2000308	biological_process	negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
A	2001205	biological_process	negative regulation of osteoclast development

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 690

Chain	Residue
A	ASP60
A	TYR92
A	TYR192
A	HIS253
A	CO3692

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE FE A 691

Chain	Residue
A	ASP395
A	TYR433
A	TYR526
A	HIS595
A	CO3693

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CO3 A 692

Chain	Residue
A	ASP60
A	TYR92
A	THR117
A	ARG121
A	ALA123
A	GLY124
A	TYR192
A	HIS253
A	FE690

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CO3 A 693

Chain	Residue
A	ASP395
A	TYR433
A	THR459
A	ARG463
A	THR464
A	ALA465
A	GLY466
A	TYR526
A	HIS595
A	FE691

site_id	FE1
Number of Residues	5
Details	IRON BINDING SITE IN N-LOBE.

Chain	Residue
A	ASP60
A	TYR92
A	TYR192
A	HIS253
A	CO3692

site_id	FE2
Number of Residues	5
Details	IRON BINDING SITE IN C-LOBE.

Chain	Residue
A	CO3693
A	ASP395
A	TYR433
A	TYR526
A	HIS595

Functional Information from PROSITE/UniProt

site_id	PS00205
Number of Residues	10
Details	TRANSFERRIN_LIKE_1 Transferrin-like domain signature 1. YyAVAVVKKG

Chain	Residue	Details
A	TYR92-GLY101
A	TYR433-ALA442

site_id	PS00206
Number of Residues	17
Details	TRANSFERRIN_LIKE_2 Transferrin-like domain signature 2. YsGAFKCLqdgaGDVAF

Chain	Residue	Details
A	TYR192-PHE208
A	TYR526-PHE542

site_id	PS00207
Number of Residues	31
Details	TRANSFERRIN_LIKE_3 Transferrin-like domain signature 3. QYeLLClNntrap...VdafkeChlAqvpsHaVV

Chain	Residue	Details
A	GLN226-VAL256
A	ASP568-VAL598

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	327
Details	Domain: {"description":"Transferrin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	329
Details	Domain: {"description":"Transferrin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	1
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"PubMed","id":"10531476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10818344","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BIY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10531476","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10818344","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PDB","id":"1BIY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1CE2","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (high mannose) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2022","firstPage":"105215","lastPage":"105215","volume":"127","journal":"Int. Dairy J.","title":"N-glycoprofiling of lactoferrin with site-specificity from buffalo colostrum.","authors":["Gnanesh Kumar B.S.","Lijina P.","Akshata S.H."],"citationCrossReferences":[{"database":"DOI","id":"10.1016/j.idairyj.2021.105215"}]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (hybrid) asparagine","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2022","firstPage":"105215","lastPage":"105215","volume":"127","journal":"Int. Dairy J.","title":"N-glycoprofiling of lactoferrin with site-specificity from buffalo colostrum.","authors":["Gnanesh Kumar B.S.","Lijina P.","Akshata S.H."],"citationCrossReferences":[{"database":"DOI","id":"10.1016/j.idairyj.2021.105215"}]}}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) (hybrid) asparagine; alternate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00498","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"journal article","publicationDate":"2022","firstPage":"105215","lastPage":"105215","volume":"127","journal":"Int. Dairy J.","title":"N-glycoprofiling of lactoferrin with site-specificity from buffalo colostrum.","authors":["Gnanesh Kumar B.S.","Lijina P.","Akshata S.H."],"citationCrossReferences":[{"database":"DOI","id":"10.1016/j.idairyj.2021.105215"}]}}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)