1BIQ
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN MUTANT E238A
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| A | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| A | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| A | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| A | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0004748 | molecular_function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005971 | cellular_component | ribonucleoside-diphosphate reductase complex |
| B | 0009185 | biological_process | ribonucleoside diphosphate metabolic process |
| B | 0009263 | biological_process | deoxyribonucleotide biosynthetic process |
| B | 0009265 | biological_process | 2'-deoxyribonucleotide biosynthetic process |
| B | 0015949 | biological_process | nucleobase-containing small molecule interconversion |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE FE2 A 376 |
| Chain | Residue |
| A | ASP84 |
| A | GLU115 |
| A | HIS118 |
| A | MTY208 |
| A | FE377 |
| A | OH378 |
| A | OH379 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE FE A 377 |
| Chain | Residue |
| A | GLU115 |
| A | GLU204 |
| A | MTY208 |
| A | HIS241 |
| A | FE2376 |
| A | OH378 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE2 B 376 |
| Chain | Residue |
| B | ASP84 |
| B | GLU115 |
| B | HIS118 |
| B | FE2377 |
| B | OH378 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE FE2 B 377 |
| Chain | Residue |
| B | GLU115 |
| B | GLU204 |
| B | HIS241 |
| B | FE2376 |
| B | OH378 |
| site_id | AC5 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE OH A 378 |
| Chain | Residue |
| A | GLU115 |
| A | HIS118 |
| A | GLU204 |
| A | MTY208 |
| A | HIS241 |
| A | FE2376 |
| A | FE377 |
| A | OH379 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE OH A 379 |
| Chain | Residue |
| A | ASP84 |
| A | HIS118 |
| A | MTY208 |
| A | ILE234 |
| A | FE2376 |
| A | OH378 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE OH B 378 |
| Chain | Residue |
| B | GLU115 |
| B | HIS118 |
| B | GLU204 |
| B | ALA238 |
| B | HIS241 |
| B | FE2376 |
| B | FE2377 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HG A 380 |
| Chain | Residue |
| A | TYR156 |
| A | TYR157 |
| A | CYS196 |
| A | VAL200 |
| A | HG385 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG B 379 |
| Chain | Residue |
| B | TYR157 |
| B | CYS196 |
| B | VAL200 |
| B | HG381 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG B 380 |
| Chain | Residue |
| B | TYR194 |
| B | LEU195 |
| B | CYS268 |
| B | CYS272 |
| site_id | BC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HG B 381 |
| Chain | Residue |
| B | TYR156 |
| B | TYR157 |
| B | CYS196 |
| B | VAL200 |
| B | HG379 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 381 |
| Chain | Residue |
| A | TYR194 |
| A | LEU195 |
| A | CYS268 |
| A | CYS272 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG B 382 |
| Chain | Residue |
| B | ILE72 |
| B | CYS214 |
| B | PHE218 |
| B | MET296 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE HG A 382 |
| Chain | Residue |
| A | TYR194 |
| A | ALA265 |
| A | CYS272 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HG A 383 |
| Chain | Residue |
| A | VAL210 |
| A | ALA213 |
| A | CYS214 |
| A | LEU304 |
| A | HG386 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG A 384 |
| Chain | Residue |
| A | LYS284 |
| A | CYS305 |
| A | GLN306 |
| A | GLU309 |
| site_id | BC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE HG B 383 |
| Chain | Residue |
| B | TYR194 |
| site_id | BC9 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 384 |
| Chain | Residue |
| B | CYS305 |
| B | GLU309 |
| site_id | CC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE HG B 385 |
| Chain | Residue |
| B | MET198 |
| B | CYS272 |
| site_id | CC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HG B 386 |
| Chain | Residue |
| B | VAL210 |
| B | ALA213 |
| B | CYS214 |
| B | LEU304 |
| B | HG387 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE HG B 387 |
| Chain | Residue |
| B | ASN76 |
| B | VAL210 |
| B | CYS214 |
| B | HG386 |
| site_id | CC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HG A 385 |
| Chain | Residue |
| A | TYR157 |
| A | CYS196 |
| A | LEU197 |
| A | VAL200 |
| A | HG380 |
| site_id | CC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE HG A 386 |
| Chain | Residue |
| A | ASN76 |
| A | VAL210 |
| A | CYS214 |
| A | LEU290 |
| A | HG383 |
| site_id | FE1 |
| Number of Residues | 7 |
| Details | DIIRON CLUSTER IN CHAIN A. |
| Chain | Residue |
| A | ASP84 |
| A | GLU115 |
| A | HIS118 |
| A | GLU204 |
| A | HIS241 |
| B | FE2376 |
| B | FE2377 |
| site_id | FE2 |
| Number of Residues | 7 |
| Details | DIIRON CLUSTER IN CHAIN B. |
| Chain | Residue |
| B | HIS118 |
| B | GLU204 |
| B | HIS241 |
| A | FE2376 |
| A | FE377 |
| B | ASP84 |
| B | GLU115 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: |
| Chain | Residue | Details |
| B | THR123 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| B | SER85 | |
| B | THR116 | |
| B | SER119 | |
| B | ALA205 | |
| B | ALA239 | |
| B | LEU242 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xik |
| Chain | Residue | Details |
| B | PHE122 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1xik |
| Chain | Residue | Details |
| A | PHE122 |
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 918 |
| Chain | Residue | Details |
| B | THR123 | pi-pi interaction, single electron relay |
| B | ALA238 |
