Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1BHN

NUCLEOSIDE DIPHOSPHATE KINASE ISOFORM A FROM BOVINE RETINA

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006897	biological_process	endocytosis
A	0007399	biological_process	nervous system development
A	0009117	biological_process	nucleotide metabolic process
A	0016020	cellular_component	membrane
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0030154	biological_process	cell differentiation
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006897	biological_process	endocytosis
B	0007399	biological_process	nervous system development
B	0009117	biological_process	nucleotide metabolic process
B	0016020	cellular_component	membrane
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0030154	biological_process	cell differentiation
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005886	cellular_component	plasma membrane
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0006897	biological_process	endocytosis
C	0007399	biological_process	nervous system development
C	0009117	biological_process	nucleotide metabolic process
C	0016020	cellular_component	membrane
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0030154	biological_process	cell differentiation
C	0046872	molecular_function	metal ion binding
D	0000166	molecular_function	nucleotide binding
D	0004550	molecular_function	nucleoside diphosphate kinase activity
D	0005524	molecular_function	ATP binding
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005886	cellular_component	plasma membrane
D	0006183	biological_process	GTP biosynthetic process
D	0006228	biological_process	UTP biosynthetic process
D	0006241	biological_process	CTP biosynthetic process
D	0006897	biological_process	endocytosis
D	0007399	biological_process	nervous system development
D	0009117	biological_process	nucleotide metabolic process
D	0016020	cellular_component	membrane
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016740	molecular_function	transferase activity
D	0030154	biological_process	cell differentiation
D	0046872	molecular_function	metal ion binding
E	0000166	molecular_function	nucleotide binding
E	0004550	molecular_function	nucleoside diphosphate kinase activity
E	0005524	molecular_function	ATP binding
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005886	cellular_component	plasma membrane
E	0006183	biological_process	GTP biosynthetic process
E	0006228	biological_process	UTP biosynthetic process
E	0006241	biological_process	CTP biosynthetic process
E	0006897	biological_process	endocytosis
E	0007399	biological_process	nervous system development
E	0009117	biological_process	nucleotide metabolic process
E	0016020	cellular_component	membrane
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016740	molecular_function	transferase activity
E	0030154	biological_process	cell differentiation
E	0046872	molecular_function	metal ion binding
F	0000166	molecular_function	nucleotide binding
F	0004550	molecular_function	nucleoside diphosphate kinase activity
F	0005524	molecular_function	ATP binding
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005886	cellular_component	plasma membrane
F	0006183	biological_process	GTP biosynthetic process
F	0006228	biological_process	UTP biosynthetic process
F	0006241	biological_process	CTP biosynthetic process
F	0006897	biological_process	endocytosis
F	0007399	biological_process	nervous system development
F	0009117	biological_process	nucleotide metabolic process
F	0016020	cellular_component	membrane
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016740	molecular_function	transferase activity
F	0030154	biological_process	cell differentiation
F	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	A
Number of Residues	6
Details	C-GMP AND GDP ARE FOUND (EACH WITH HALF OCCUPANCY) IN THE NUCLEOTIDE BINDING SITE.

Chain	Residue
A	LYS12
A	TYR52
A	VAL112
A	ASN115
A	HIS118
A	GLU152

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 35G A 160

Chain	Residue
A	LYS12
A	TYR52
A	PHE60
A	ARG105
A	VAL112
A	ASN115
A	HIS118
A	GDP161
A	HOH502

site_id	AC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GDP A 161

Chain	Residue
A	LYS12
A	PHE60
A	ARG88
A	THR94
A	ARG105
A	VAL112
A	GLY113
A	ASN115
A	HIS118
A	35G160
A	HOH502
B	GLU152

site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 35G B 160

Chain	Residue
B	LYS12
B	TYR52
B	PHE60
B	ARG105
B	VAL112
B	ASN115
B	HIS118
B	GDP161
B	HOH372
B	HOH503
C	GLU152

site_id	AC4
Number of Residues	15
Details	BINDING SITE FOR RESIDUE GDP B 161

Chain	Residue
B	LYS12
B	TYR52
B	LEU55
B	PHE60
B	LEU64
B	ARG88
B	VAL112
B	ASN115
B	HIS118
B	GLY119
B	35G160
B	HOH204
B	HOH372
B	HOH503
C	GLU152

site_id	AC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE 35G C 160

Chain	Residue
C	LYS12
C	TYR52
C	PHE60
C	LEU64
C	THR94
C	ASN115
C	HIS118
C	GDP161
C	HOH238
C	HOH505

site_id	AC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GDP C 161

Chain	Residue
C	ARG105
C	VAL112
C	ASN115
C	35G160
C	HOH497
C	HOH505
A	GLU152
C	LYS12
C	PHE60
C	LEU64
C	ARG88
C	THR94

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE 35G D 160

Chain	Residue
D	LYS12
D	TYR52
D	PHE60
D	LEU64
D	VAL112
D	GLY113
D	ASN115
D	HIS118
D	GDP161

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE GDP D 161

Chain	Residue
D	LYS12
D	LEU55
D	PHE60
D	LEU64
D	ARG88
D	THR94
D	ARG105
D	VAL112
D	ASN115
D	35G160
D	HOH285
D	HOH507

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE 35G E 160

Chain	Residue
E	LYS12
E	PHE60
E	THR94
E	ASN115
E	HIS118
E	GDP161
E	HOH221
F	GLU152

site_id	B
Number of Residues	6
Details	C-GMP AND GDP ARE FOUND (EACH WITH HALF OCCUPANCY) IN THE NUCLEOTIDE BINDING SITE.

Chain	Residue
B	ASN115
B	HIS118
B	GLU152
B	LYS12
B	TYR52
B	VAL112

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE GDP E 161

Chain	Residue
E	LYS12
E	PHE60
E	LEU64
E	ARG88
E	THR94
E	VAL112
E	ASN115
E	35G160
E	HOH221
E	HOH266
F	GLU152

site_id	BC2
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 35G F 160

Chain	Residue
D	GLU152
F	LYS12
F	TYR52
F	PHE60
F	ARG105
F	VAL112
F	GLY113
F	ASN115
F	HIS118
F	GDP161
F	HOH377
F	HOH494

site_id	BC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE GDP F 161

Chain	Residue
D	GLU152
F	LYS12
F	LEU55
F	PHE60
F	LEU64
F	ARG88
F	THR94
F	VAL112
F	ASN115
F	HIS118
F	35G160
F	HOH377
F	HOH494
F	HOH495

site_id	C
Number of Residues	6
Details	C-GMP AND GDP ARE FOUND (EACH WITH HALF OCCUPANCY) IN THE NUCLEOTIDE BINDING SITE.

Chain	Residue
C	LYS12
C	TYR52
C	VAL112
C	ASN115
C	HIS118
C	GLU152

site_id	D
Number of Residues	6
Details	C-GMP AND GDP ARE FOUND (EACH WITH HALF OCCUPANCY) IN THE NUCLEOTIDE BINDING SITE.

Chain	Residue
D	LYS12
D	TYR52
D	VAL112
D	ASN115
D	HIS118
D	GLU152

site_id	E
Number of Residues	6
Details	C-GMP AND GDP ARE FOUND (EACH WITH HALF OCCUPANCY) IN THE NUCLEOTIDE BINDING SITE.

Chain	Residue
E	LYS12
E	TYR52
E	VAL112
E	ASN115
E	HIS118
E	GLU152

site_id	F
Number of Residues	6
Details	C-GMP AND GDP ARE FOUND (EACH WITH HALF OCCUPANCY) IN THE NUCLEOTIDE BINDING SITE.

Chain	Residue
F	LYS12
F	TYR52
F	VAL112
F	ASN115
F	HIS118
F	GLU152

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDSV

Chain	Residue	Details
A	ASN115-VAL123

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	ACT_SITE: Pros-phosphohistidine intermediate

Chain	Residue	Details
A	GLY119
B	GLY119
C	GLY119
D	GLY119
E	GLY119
F	GLY119

site_id	SWS_FT_FI2
Number of Residues	36
Details	BINDING:

Chain	Residue	Details
A	PRO13
B	ASN95
B	GLY106
B	ILE116
C	PRO13
C	PHE61
C	VAL89
C	ASN95
C	GLY106
C	ILE116
D	PRO13
A	PHE61
D	PHE61
D	VAL89
D	ASN95
D	GLY106
D	ILE116
E	PRO13
E	PHE61
E	VAL89
E	ASN95
E	GLY106
A	VAL89
E	ILE116
F	PRO13
F	PHE61
F	VAL89
F	ASN95
F	GLY106
F	ILE116
A	ASN95
A	GLY106
A	ILE116
B	PRO13
B	PHE61
B	VAL89

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)