1BG3

RAT BRAIN HEXOKINASE TYPE I COMPLEX WITH GLUCOSE AND INHIBITOR GLUCOSE-6-PHOSPHATE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001666	biological_process	response to hypoxia
A	0001678	biological_process	intracellular glucose homeostasis
A	0002931	biological_process	response to ischemia
A	0004340	molecular_function	glucokinase activity
A	0004396	molecular_function	hexokinase activity
A	0004672	molecular_function	protein kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005536	molecular_function	D-glucose binding
A	0005739	cellular_component	mitochondrion
A	0005741	cellular_component	mitochondrial outer membrane
A	0005829	cellular_component	cytosol
A	0005901	cellular_component	caveola
A	0005975	biological_process	carbohydrate metabolic process
A	0006002	biological_process	fructose 6-phosphate metabolic process
A	0006006	biological_process	glucose metabolic process
A	0006013	biological_process	mannose metabolic process
A	0006096	biological_process	glycolytic process
A	0006468	biological_process	protein phosphorylation
A	0008865	molecular_function	fructokinase activity
A	0009741	biological_process	response to brassinosteroid
A	0016887	molecular_function	ATP hydrolysis activity
A	0018105	biological_process	peptidyl-serine phosphorylation
A	0018107	biological_process	peptidyl-threonine phosphorylation
A	0018108	biological_process	peptidyl-tyrosine phosphorylation
A	0019158	molecular_function	mannokinase activity
A	0019318	biological_process	hexose metabolic process
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0043066	biological_process	negative regulation of apoptotic process
A	0046777	biological_process	protein autophosphorylation
A	0046835	biological_process	carbohydrate phosphorylation
A	0047931	molecular_function	glucosamine kinase activity
A	0051156	biological_process	glucose 6-phosphate metabolic process
A	1901986	biological_process	response to ketamine
A	1903960	biological_process	negative regulation of anion transmembrane transport
B	0001666	biological_process	response to hypoxia
B	0001678	biological_process	intracellular glucose homeostasis
B	0002931	biological_process	response to ischemia
B	0004340	molecular_function	glucokinase activity
B	0004396	molecular_function	hexokinase activity
B	0004672	molecular_function	protein kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005536	molecular_function	D-glucose binding
B	0005739	cellular_component	mitochondrion
B	0005741	cellular_component	mitochondrial outer membrane
B	0005829	cellular_component	cytosol
B	0005901	cellular_component	caveola
B	0005975	biological_process	carbohydrate metabolic process
B	0006002	biological_process	fructose 6-phosphate metabolic process
B	0006006	biological_process	glucose metabolic process
B	0006013	biological_process	mannose metabolic process
B	0006096	biological_process	glycolytic process
B	0006468	biological_process	protein phosphorylation
B	0008865	molecular_function	fructokinase activity
B	0009741	biological_process	response to brassinosteroid
B	0016887	molecular_function	ATP hydrolysis activity
B	0018105	biological_process	peptidyl-serine phosphorylation
B	0018107	biological_process	peptidyl-threonine phosphorylation
B	0018108	biological_process	peptidyl-tyrosine phosphorylation
B	0019158	molecular_function	mannokinase activity
B	0019318	biological_process	hexose metabolic process
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0043066	biological_process	negative regulation of apoptotic process
B	0046777	biological_process	protein autophosphorylation
B	0046835	biological_process	carbohydrate phosphorylation
B	0047931	molecular_function	glucosamine kinase activity
B	0051156	biological_process	glucose 6-phosphate metabolic process
B	1901986	biological_process	response to ketamine
B	1903960	biological_process	negative regulation of anion transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00378
Number of Residues	26
Details	HEXOKINASE_1 Hexokinase domain signature. VGFTFSFPcrqskIDeavLitWTKrF

Chain	Residue	Details
A	VAL150-PHE175
A	LEU598-PHE623

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	18
Details	Region: {"description":"Mitochondrial-binding peptide (MBP)","evidences":[{"source":"UniProtKB","id":"P19367","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	478
Details	Region: {"description":"Hexokinase large subdomain 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	478
Details	Region: {"description":"Hexokinase large subdomain 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	42
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P19367","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	64
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9665168","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1BG3","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"N-acetylmethionine","evidences":[{"source":"UniProtKB","id":"P19367","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	442
Details	Domain: {"description":"Hexokinase 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	134
Details	Region: {"description":"Hexokinase small subdomain 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---