1BCF
THE STRUCTURE OF A UNIQUE, TWO-FOLD SYMMETRIC, HAEM-BINDING SITE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004322 | molecular_function | ferroxidase activity |
| A | 0005506 | molecular_function | iron ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0006826 | biological_process | iron ion transport |
| A | 0006879 | biological_process | intracellular iron ion homeostasis |
| A | 0008199 | molecular_function | ferric iron binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0140315 | molecular_function | iron ion sequestering activity |
| B | 0004322 | molecular_function | ferroxidase activity |
| B | 0005506 | molecular_function | iron ion binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005829 | cellular_component | cytosol |
| B | 0006826 | biological_process | iron ion transport |
| B | 0006879 | biological_process | intracellular iron ion homeostasis |
| B | 0008199 | molecular_function | ferric iron binding |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0020037 | molecular_function | heme binding |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0046872 | molecular_function | metal ion binding |
| B | 0140315 | molecular_function | iron ion sequestering activity |
| C | 0004322 | molecular_function | ferroxidase activity |
| C | 0005506 | molecular_function | iron ion binding |
| C | 0005515 | molecular_function | protein binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0006826 | biological_process | iron ion transport |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0008199 | molecular_function | ferric iron binding |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0020037 | molecular_function | heme binding |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0140315 | molecular_function | iron ion sequestering activity |
| D | 0004322 | molecular_function | ferroxidase activity |
| D | 0005506 | molecular_function | iron ion binding |
| D | 0005515 | molecular_function | protein binding |
| D | 0005829 | cellular_component | cytosol |
| D | 0006826 | biological_process | iron ion transport |
| D | 0006879 | biological_process | intracellular iron ion homeostasis |
| D | 0008199 | molecular_function | ferric iron binding |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0020037 | molecular_function | heme binding |
| D | 0042802 | molecular_function | identical protein binding |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0046872 | molecular_function | metal ion binding |
| D | 0140315 | molecular_function | iron ion sequestering activity |
| E | 0004322 | molecular_function | ferroxidase activity |
| E | 0005506 | molecular_function | iron ion binding |
| E | 0005515 | molecular_function | protein binding |
| E | 0005829 | cellular_component | cytosol |
| E | 0006826 | biological_process | iron ion transport |
| E | 0006879 | biological_process | intracellular iron ion homeostasis |
| E | 0008199 | molecular_function | ferric iron binding |
| E | 0016020 | cellular_component | membrane |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0020037 | molecular_function | heme binding |
| E | 0042802 | molecular_function | identical protein binding |
| E | 0042803 | molecular_function | protein homodimerization activity |
| E | 0046872 | molecular_function | metal ion binding |
| E | 0140315 | molecular_function | iron ion sequestering activity |
| F | 0004322 | molecular_function | ferroxidase activity |
| F | 0005506 | molecular_function | iron ion binding |
| F | 0005515 | molecular_function | protein binding |
| F | 0005829 | cellular_component | cytosol |
| F | 0006826 | biological_process | iron ion transport |
| F | 0006879 | biological_process | intracellular iron ion homeostasis |
| F | 0008199 | molecular_function | ferric iron binding |
| F | 0016020 | cellular_component | membrane |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0020037 | molecular_function | heme binding |
| F | 0042802 | molecular_function | identical protein binding |
| F | 0042803 | molecular_function | protein homodimerization activity |
| F | 0046872 | molecular_function | metal ion binding |
| F | 0140315 | molecular_function | iron ion sequestering activity |
| G | 0004322 | molecular_function | ferroxidase activity |
| G | 0005506 | molecular_function | iron ion binding |
| G | 0005515 | molecular_function | protein binding |
| G | 0005829 | cellular_component | cytosol |
| G | 0006826 | biological_process | iron ion transport |
| G | 0006879 | biological_process | intracellular iron ion homeostasis |
| G | 0008199 | molecular_function | ferric iron binding |
| G | 0016020 | cellular_component | membrane |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0020037 | molecular_function | heme binding |
| G | 0042802 | molecular_function | identical protein binding |
| G | 0042803 | molecular_function | protein homodimerization activity |
| G | 0046872 | molecular_function | metal ion binding |
| G | 0140315 | molecular_function | iron ion sequestering activity |
| H | 0004322 | molecular_function | ferroxidase activity |
| H | 0005506 | molecular_function | iron ion binding |
| H | 0005515 | molecular_function | protein binding |
| H | 0005829 | cellular_component | cytosol |
| H | 0006826 | biological_process | iron ion transport |
| H | 0006879 | biological_process | intracellular iron ion homeostasis |
| H | 0008199 | molecular_function | ferric iron binding |
| H | 0016020 | cellular_component | membrane |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0020037 | molecular_function | heme binding |
| H | 0042802 | molecular_function | identical protein binding |
| H | 0042803 | molecular_function | protein homodimerization activity |
| H | 0046872 | molecular_function | metal ion binding |
| H | 0140315 | molecular_function | iron ion sequestering activity |
| I | 0004322 | molecular_function | ferroxidase activity |
| I | 0005506 | molecular_function | iron ion binding |
| I | 0005515 | molecular_function | protein binding |
| I | 0005829 | cellular_component | cytosol |
| I | 0006826 | biological_process | iron ion transport |
| I | 0006879 | biological_process | intracellular iron ion homeostasis |
| I | 0008199 | molecular_function | ferric iron binding |
| I | 0016020 | cellular_component | membrane |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0020037 | molecular_function | heme binding |
| I | 0042802 | molecular_function | identical protein binding |
| I | 0042803 | molecular_function | protein homodimerization activity |
| I | 0046872 | molecular_function | metal ion binding |
| I | 0140315 | molecular_function | iron ion sequestering activity |
| J | 0004322 | molecular_function | ferroxidase activity |
| J | 0005506 | molecular_function | iron ion binding |
| J | 0005515 | molecular_function | protein binding |
| J | 0005829 | cellular_component | cytosol |
| J | 0006826 | biological_process | iron ion transport |
| J | 0006879 | biological_process | intracellular iron ion homeostasis |
| J | 0008199 | molecular_function | ferric iron binding |
| J | 0016020 | cellular_component | membrane |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0020037 | molecular_function | heme binding |
| J | 0042802 | molecular_function | identical protein binding |
| J | 0042803 | molecular_function | protein homodimerization activity |
| J | 0046872 | molecular_function | metal ion binding |
| J | 0140315 | molecular_function | iron ion sequestering activity |
| K | 0004322 | molecular_function | ferroxidase activity |
| K | 0005506 | molecular_function | iron ion binding |
| K | 0005515 | molecular_function | protein binding |
| K | 0005829 | cellular_component | cytosol |
| K | 0006826 | biological_process | iron ion transport |
| K | 0006879 | biological_process | intracellular iron ion homeostasis |
| K | 0008199 | molecular_function | ferric iron binding |
| K | 0016020 | cellular_component | membrane |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0020037 | molecular_function | heme binding |
| K | 0042802 | molecular_function | identical protein binding |
| K | 0042803 | molecular_function | protein homodimerization activity |
| K | 0046872 | molecular_function | metal ion binding |
| K | 0140315 | molecular_function | iron ion sequestering activity |
| L | 0004322 | molecular_function | ferroxidase activity |
| L | 0005506 | molecular_function | iron ion binding |
| L | 0005515 | molecular_function | protein binding |
| L | 0005829 | cellular_component | cytosol |
| L | 0006826 | biological_process | iron ion transport |
| L | 0006879 | biological_process | intracellular iron ion homeostasis |
| L | 0008199 | molecular_function | ferric iron binding |
| L | 0016020 | cellular_component | membrane |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0020037 | molecular_function | heme binding |
| L | 0042802 | molecular_function | identical protein binding |
| L | 0042803 | molecular_function | protein homodimerization activity |
| L | 0046872 | molecular_function | metal ion binding |
| L | 0140315 | molecular_function | iron ion sequestering activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 600 |
| Chain | Residue |
| A | HIS130 |
| A | GLU51 |
| A | GLU94 |
| A | GLU127 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN A 601 |
| Chain | Residue |
| A | GLU18 |
| A | GLU51 |
| A | HIS54 |
| A | GLU127 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 600 |
| Chain | Residue |
| B | GLU51 |
| B | GLU94 |
| B | GLU127 |
| B | HIS130 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN B 601 |
| Chain | Residue |
| B | GLU18 |
| B | GLU51 |
| B | HIS54 |
| B | GLU127 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN C 600 |
| Chain | Residue |
| C | GLU51 |
| C | GLU94 |
| C | GLU127 |
| C | HIS130 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN C 601 |
| Chain | Residue |
| C | GLU18 |
| C | GLU51 |
| C | HIS54 |
| C | GLU127 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN D 600 |
| Chain | Residue |
| D | GLU51 |
| D | GLU94 |
| D | GLU127 |
| D | HIS130 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN D 601 |
| Chain | Residue |
| D | GLU18 |
| D | GLU51 |
| D | HIS54 |
| D | GLU127 |
| site_id | AC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN E 600 |
| Chain | Residue |
| E | GLU51 |
| E | GLU94 |
| E | GLU127 |
| E | HIS130 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN E 601 |
| Chain | Residue |
| E | GLU18 |
| E | GLU51 |
| E | HIS54 |
| E | GLU127 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN F 600 |
| Chain | Residue |
| F | GLU51 |
| F | GLU94 |
| F | GLU127 |
| F | HIS130 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN F 601 |
| Chain | Residue |
| F | GLU18 |
| F | GLU51 |
| F | HIS54 |
| F | GLU127 |
| site_id | BC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN G 600 |
| Chain | Residue |
| G | GLU51 |
| G | GLU94 |
| G | GLU127 |
| G | HIS130 |
| site_id | BC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN G 601 |
| Chain | Residue |
| G | GLU18 |
| G | GLU51 |
| G | HIS54 |
| G | GLU127 |
| site_id | BC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN H 600 |
| Chain | Residue |
| H | GLU51 |
| H | GLU94 |
| H | GLU127 |
| H | HIS130 |
| site_id | BC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN H 601 |
| Chain | Residue |
| H | GLU18 |
| H | GLU51 |
| H | HIS54 |
| H | GLU127 |
| site_id | BC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN I 600 |
| Chain | Residue |
| I | GLU51 |
| I | GLU94 |
| I | GLU127 |
| I | HIS130 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN I 601 |
| Chain | Residue |
| I | GLU18 |
| I | GLU51 |
| I | HIS54 |
| I | GLU127 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN J 600 |
| Chain | Residue |
| J | GLU51 |
| J | GLU94 |
| J | GLU127 |
| J | HIS130 |
| site_id | CC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN J 601 |
| Chain | Residue |
| J | GLU18 |
| J | GLU51 |
| J | HIS54 |
| J | GLU127 |
| site_id | CC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN K 600 |
| Chain | Residue |
| K | GLU51 |
| K | GLU94 |
| K | GLU127 |
| K | HIS130 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN K 601 |
| Chain | Residue |
| K | GLU18 |
| K | GLU51 |
| K | HIS54 |
| K | GLU127 |
| site_id | CC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN L 600 |
| Chain | Residue |
| L | GLU51 |
| L | GLU94 |
| L | GLU127 |
| L | HIS130 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MN L 601 |
| Chain | Residue |
| L | GLU18 |
| L | GLU51 |
| L | HIS54 |
| L | GLU127 |
| site_id | CC7 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEM A 200 |
| Chain | Residue |
| A | ASN23 |
| A | TYR45 |
| A | MET52 |
| A | ILE59 |
| B | LEU19 |
| B | ASN23 |
| B | PHE26 |
| B | MET52 |
| B | LYS53 |
| site_id | CC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEM C 201 |
| Chain | Residue |
| C | ASN23 |
| C | TYR45 |
| C | MET52 |
| C | ILE59 |
| D | LEU19 |
| D | ASN23 |
| D | PHE26 |
| D | MET52 |
| D | LYS53 |
| site_id | CC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEM E 202 |
| Chain | Residue |
| E | ASN23 |
| E | TYR45 |
| E | MET52 |
| E | ILE59 |
| F | LEU19 |
| F | ASN23 |
| F | PHE26 |
| F | MET52 |
| F | LYS53 |
| site_id | DC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEM G 203 |
| Chain | Residue |
| G | ASN23 |
| G | TYR45 |
| G | MET52 |
| G | ILE59 |
| H | LEU19 |
| H | ASN23 |
| H | PHE26 |
| H | MET52 |
| H | LYS53 |
| site_id | DC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEM I 204 |
| Chain | Residue |
| I | ASN23 |
| I | TYR45 |
| I | MET52 |
| I | ILE59 |
| J | LEU19 |
| J | ASN23 |
| J | PHE26 |
| J | MET52 |
| J | LYS53 |
| site_id | DC3 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE HEM K 205 |
| Chain | Residue |
| K | ASN23 |
| K | TYR45 |
| K | MET52 |
| K | ILE59 |
| L | LEU19 |
| L | ASN23 |
| L | PHE26 |
| L | MET52 |
| L | LYS53 |
| site_id | MA1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| A | GLU18 |
| A | GLU51 |
| A | HIS54 |
| A | GLU127 |
| site_id | MA2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| A | GLU51 |
| A | GLU94 |
| A | GLU127 |
| A | HIS130 |
| site_id | MB1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| B | GLU51 |
| B | HIS54 |
| B | GLU127 |
| B | GLU18 |
| site_id | MB2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| B | GLU51 |
| B | GLU94 |
| B | GLU127 |
| B | HIS130 |
| site_id | MC1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| C | GLU18 |
| C | GLU51 |
| C | HIS54 |
| C | GLU127 |
| site_id | MC2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| C | GLU51 |
| C | GLU94 |
| C | GLU127 |
| C | HIS130 |
| site_id | MD1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| D | GLU18 |
| D | GLU51 |
| D | HIS54 |
| D | GLU127 |
| site_id | MD2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| D | GLU51 |
| D | GLU94 |
| D | GLU127 |
| D | HIS130 |
| site_id | ME1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| E | GLU18 |
| E | GLU51 |
| E | HIS54 |
| E | GLU127 |
| site_id | ME2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| E | GLU51 |
| E | GLU94 |
| E | GLU127 |
| E | HIS130 |
| site_id | MF1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| F | GLU18 |
| F | GLU51 |
| F | HIS54 |
| F | GLU127 |
| site_id | MF2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| F | GLU51 |
| F | GLU94 |
| F | GLU127 |
| F | HIS130 |
| site_id | MG1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| G | GLU18 |
| G | GLU51 |
| G | HIS54 |
| G | GLU127 |
| site_id | MG2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| G | GLU51 |
| G | GLU94 |
| G | GLU127 |
| G | HIS130 |
| site_id | MH1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| H | GLU18 |
| H | GLU51 |
| H | HIS54 |
| H | GLU127 |
| site_id | MH2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| H | GLU51 |
| H | GLU94 |
| H | GLU127 |
| H | HIS130 |
| site_id | MI1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| I | GLU18 |
| I | GLU51 |
| I | HIS54 |
| I | GLU127 |
| site_id | MI2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| I | GLU51 |
| I | GLU94 |
| I | GLU127 |
| I | HIS130 |
| site_id | MJ1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| J | GLU18 |
| J | GLU51 |
| J | HIS54 |
| J | GLU127 |
| site_id | MJ2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| J | GLU51 |
| J | GLU94 |
| J | GLU127 |
| J | HIS130 |
| site_id | MK1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| K | GLU18 |
| K | GLU51 |
| K | HIS54 |
| K | GLU127 |
| site_id | MK2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| K | GLU51 |
| K | GLU94 |
| K | GLU127 |
| K | HIS130 |
| site_id | ML1 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| L | GLU18 |
| L | GLU51 |
| L | HIS54 |
| L | GLU127 |
| site_id | ML2 |
| Number of Residues | 4 |
| Details |
| Chain | Residue |
| L | GLU51 |
| L | GLU94 |
| L | GLU127 |
| L | HIS130 |
Functional Information from PROSITE/UniProt
| site_id | PS00549 |
| Number of Residues | 19 |
| Details | BACTERIOFERRITIN Bacterioferritin signature. MkGdtkVInyLnklLgneL |
| Chain | Residue | Details |
| A | MET1-LEU19 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1728 |
| Details | Domain: {"description":"Ferritin-like diiron","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 96 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17077480","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00085","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"17077480","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
