1B7U
Structure of Mare Apolactoferrin: the N and C Lobes are in the Closed Form
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001503 | biological_process | ossification |
| A | 0001817 | biological_process | regulation of cytokine production |
| A | 0002227 | biological_process | innate immune response in mucosa |
| A | 0002376 | biological_process | immune system process |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005769 | cellular_component | early endosome |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006508 | biological_process | proteolysis |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0006826 | biological_process | iron ion transport |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008236 | molecular_function | serine-type peptidase activity |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0019731 | biological_process | antibacterial humoral response |
| A | 0019732 | biological_process | antifungal humoral response |
| A | 0031665 | biological_process | negative regulation of lipopolysaccharide-mediated signaling pathway |
| A | 0032680 | biological_process | regulation of tumor necrosis factor production |
| A | 0033690 | biological_process | positive regulation of osteoblast proliferation |
| A | 0042581 | cellular_component | specific granule |
| A | 0043066 | biological_process | negative regulation of apoptotic process |
| A | 0045669 | biological_process | positive regulation of osteoblast differentiation |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051241 | biological_process | negative regulation of multicellular organismal process |
| A | 0055037 | cellular_component | recycling endosome |
| A | 0060349 | biological_process | bone morphogenesis |
| A | 1900159 | biological_process | positive regulation of bone mineralization involved in bone maturation |
| A | 1900229 | biological_process | negative regulation of single-species biofilm formation in or on host organism |
| A | 1902732 | biological_process | positive regulation of chondrocyte proliferation |
| A | 2000308 | biological_process | negative regulation of tumor necrosis factor (ligand) superfamily member 11 production |
| A | 2001205 | biological_process | negative regulation of osteoclast development |
Functional Information from PROSITE/UniProt
| site_id | PS00205 |
| Number of Residues | 10 |
| Details | TRANSFERRIN_LIKE_1 Transferrin-like domain signature 1. YyAVAVVKKG |
| Chain | Residue | Details |
| A | TYR92-GLY101 | |
| A | TYR433-SER442 |
| site_id | PS00206 |
| Number of Residues | 17 |
| Details | TRANSFERRIN_LIKE_2 Transferrin-like domain signature 2. YsGAFKCLengaGDVAF |
| Chain | Residue | Details |
| A | TYR192-PHE208 | |
| A | TYR526-PHE542 |
| site_id | PS00207 |
| Number of Residues | 31 |
| Details | TRANSFERRIN_LIKE_3 Transferrin-like domain signature 3. KYeLLCpDntrkp...VdafkeChlArvpsHaVV |
| Chain | Residue | Details |
| A | LYS226-VAL256 | |
| A | ASP568-VAL598 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 327 |
| Details | Domain: {"description":"Transferrin-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 329 |
| Details | Domain: {"description":"Transferrin-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10531474","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"11599026","evidenceCode":"ECO:0000269"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of the complex of Lactoferrin with 6-(Hydroxymethyl)oxane-2,3,4,5-tetrol at 3.49 A resolution.","authors":["Mir R.","Kaur A.","Singh A.K.","Singh N.","Kaur P.","Sharma S.","Singh T.P."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00741","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"10366507","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"10531475","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"APR-2008","submissionDatabase":"PDB data bank","title":"Crystal structure of the complex of Lactoferrin with 6-(Hydroxymethyl)oxane-2,3,4,5-tetrol at 3.49 A resolution.","authors":["Mir R.","Kaur A.","Singh A.K.","Singh N.","Kaur P.","Sharma S.","Singh T.P."]}}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 3 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
