1B6Z
6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003874 | molecular_function | 6-pyruvoyltetrahydropterin synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046146 | biological_process | tetrahydrobiopterin metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0003874 | molecular_function | 6-pyruvoyltetrahydropterin synthase activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005829 | cellular_component | cytosol |
| B | 0006729 | biological_process | tetrahydrobiopterin biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042802 | molecular_function | identical protein binding |
| B | 0046146 | biological_process | tetrahydrobiopterin metabolic process |
| B | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN A 401 |
| Chain | Residue |
| A | HIS23 |
| A | HIS48 |
| A | HIS50 |
| A | GLU133 |
| A | HOH469 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 402 |
| Chain | Residue |
| B | HOH457 |
| B | HIS23 |
| B | HIS48 |
| B | HIS50 |
| B | GLU133 |
Functional Information from PROSITE/UniProt
| site_id | PS00678 |
| Number of Residues | 15 |
| Details | WD_REPEATS_1 Trp-Asp (WD) repeats signature. VVSTteNvAVYIWEN |
| Chain | Residue | Details |
| A | VAL102-ASN116 |
| site_id | PS00987 |
| Number of Residues | 11 |
| Details | PTPS_1 6-pyruvoyl tetrahydropterin synthase signature 1. CNNpnGHGHNY |
| Chain | Residue | Details |
| A | CYS42-TYR52 |
| site_id | PS00988 |
| Number of Residues | 8 |
| Details | PTPS_2 6-pyruvoyl tetrahydropterin synthase signature 2. DHKNLDlD |
| Chain | Residue | Details |
| A | ASP88-ASP95 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton acceptor"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q03393","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9R1Z7","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q03393","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b66 |
| Chain | Residue | Details |
| A | CYS42 | |
| A | GLU133 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b66 |
| Chain | Residue | Details |
| B | CYS42 | |
| B | GLU133 |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b66 |
| Chain | Residue | Details |
| A | ASP88 | |
| A | HIS89 |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1b66 |
| Chain | Residue | Details |
| B | ASP88 | |
| B | HIS89 |
| site_id | MCSA1 |
| Number of Residues | 7 |
| Details | M-CSA 84 |
| Chain | Residue | Details |
| A | HIS23 | metal ligand |
| A | CYS42 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | HIS48 | metal ligand |
| A | HIS50 | metal ligand |
| A | ASP88 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS89 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| A | GLU133 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| Number of Residues | 7 |
| Details | M-CSA 84 |
| Chain | Residue | Details |
| B | HIS23 | metal ligand |
| B | CYS42 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | HIS48 | metal ligand |
| B | HIS50 | metal ligand |
| B | ASP88 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| B | HIS89 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| B | GLU133 | electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
