1B4P
CRYSTAL STRUCTURES OF CLASS MU CHIMERIC GST ISOENZYMES M1-2 AND M2-1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004364 | molecular_function | glutathione transferase activity |
| A | 0004602 | molecular_function | glutathione peroxidase activity |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005829 | cellular_component | cytosol |
| A | 0006629 | biological_process | lipid metabolic process |
| A | 0006749 | biological_process | glutathione metabolic process |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0007608 | biological_process | sensory perception of smell |
| A | 0010038 | biological_process | response to metal ion |
| A | 0010880 | biological_process | regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum |
| A | 0010881 | biological_process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| A | 0014809 | biological_process | regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion |
| A | 0016529 | cellular_component | sarcoplasmic reticulum |
| A | 0016740 | molecular_function | transferase activity |
| A | 0018916 | biological_process | nitrobenzene metabolic process |
| A | 0019855 | molecular_function | calcium channel inhibitor activity |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0033595 | biological_process | response to genistein |
| A | 0042178 | biological_process | xenobiotic catabolic process |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043295 | molecular_function | glutathione binding |
| A | 0043651 | biological_process | linoleic acid metabolic process |
| A | 0044325 | molecular_function | transmembrane transporter binding |
| A | 0051122 | biological_process | hepoxilin biosynthetic process |
| A | 0070458 | biological_process | cellular detoxification of nitrogen compound |
| A | 0071313 | biological_process | cellular response to caffeine |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 1902168 | biological_process | response to catechin |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 221 |
| Chain | Residue |
| A | ARG167 |
| A | HOH391 |
| A | HOH475 |
| A | HOH521 |
| A | HOH535 |
| site_id | AC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE SO4 A 222 |
| Chain | Residue |
| A | LEU52 |
| A | ILE63 |
| A | LYS68 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 223 |
| Chain | Residue |
| A | LYS135 |
| A | PHE202 |
| A | LEU203 |
| A | SER204 |
| A | LYS205 |
| A | HOH395 |
| A | HOH497 |
| A | HOH526 |
| site_id | AC4 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GPS A 218 |
| Chain | Residue |
| A | TYR6 |
| A | TRP7 |
| A | VAL9 |
| A | GLY11 |
| A | LEU12 |
| A | ARG42 |
| A | TRP45 |
| A | LYS49 |
| A | ASN58 |
| A | LEU59 |
| A | GLN71 |
| A | SER72 |
| A | ASP105 |
| A | TYR115 |
| A | PHE208 |
| A | ALA209 |
| A | HOH301 |
| A | HOH302 |
| A | HOH325 |
| A | HOH386 |
| A | HOH415 |
| A | HOH508 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE GPS A 219 |
| Chain | Residue |
| A | LEU20 |
| A | GLU21 |
| A | ASP24 |
| A | SER25 |
| A | SER26 |
| A | TYR27 |
| A | GLU28 |
| A | GLU29 |
| A | PRO131 |
| A | LYS172 |
| A | CYS173 |
| A | ALA176 |
| A | ARG201 |
| A | HOH384 |
| A | HOH429 |
| A | HOH533 |
| site_id | GPS |
| Number of Residues | 1 |
| Details | NON3 |
| Chain | Residue |
| A | TYR6 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 86 |
| Details | Domain: {"description":"GST N-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 124 |
| Details | Domain: {"description":"GST C-terminal"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8664265","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P15626","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1oe8 |
| Chain | Residue | Details |
| A | TYR6 |
