1AVC
BOVINE ANNEXIN VI (CALCIUM-BOUND)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001725 | cellular_component | stress fiber |
| A | 0001755 | biological_process | neural crest cell migration |
| A | 0001778 | biological_process | plasma membrane repair |
| A | 0001786 | molecular_function | phosphatidylserine binding |
| A | 0003418 | biological_process | growth plate cartilage chondrocyte differentiation |
| A | 0005262 | molecular_function | calcium channel activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005544 | molecular_function | calcium-dependent phospholipid binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005925 | cellular_component | focal adhesion |
| A | 0006816 | biological_process | calcium ion transport |
| A | 0006937 | biological_process | regulation of muscle contraction |
| A | 0008201 | molecular_function | heparin binding |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0015485 | molecular_function | cholesterol binding |
| A | 0016020 | cellular_component | membrane |
| A | 0016192 | biological_process | vesicle-mediated transport |
| A | 0019899 | molecular_function | enzyme binding |
| A | 0030061 | cellular_component | mitochondrial crista |
| A | 0031214 | biological_process | biomineral tissue development |
| A | 0031982 | cellular_component | vesicle |
| A | 0035374 | molecular_function | chondroitin sulfate binding |
| A | 0038024 | molecular_function | cargo receptor activity |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042470 | cellular_component | melanosome |
| A | 0042584 | cellular_component | chromaffin granule membrane |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0051015 | molecular_function | actin filament binding |
| A | 0051283 | biological_process | negative regulation of sequestering of calcium ion |
| A | 0051560 | biological_process | mitochondrial calcium ion homeostasis |
| A | 0070509 | biological_process | calcium ion import |
| A | 0070588 | biological_process | calcium ion transmembrane transport |
| A | 0097190 | biological_process | apoptotic signaling pathway |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 674 |
| Chain | Residue |
| A | MET376 |
| A | GLY378 |
| A | LEU379 |
| A | GLY380 |
| A | THR381 |
| A | GLU420 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE CA A 675 |
| Chain | Residue |
| A | GLU83 |
| A | LYS75 |
| A | LEU78 |
| A | THR79 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 676 |
| Chain | Residue |
| A | MET264 |
| A | GLY266 |
| A | LEU267 |
| A | GLY268 |
| A | THR269 |
| A | ASP308 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE CA A 677 |
| Chain | Residue |
| A | GLY188 |
| A | GLU189 |
| A | LYS191 |
| A | GLY193 |
| A | THR194 |
| A | SER229 |
| A | GLU233 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 678 |
| Chain | Residue |
| A | MET612 |
| A | GLY614 |
| A | ALA615 |
| A | GLY616 |
| A | THR617 |
| A | ASP656 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 679 |
| Chain | Residue |
| A | MET448 |
| A | GLU449 |
| A | GLY450 |
| A | GLY452 |
| A | ASP492 |
Functional Information from PROSITE/UniProt
| site_id | PS00223 |
| Number of Residues | 53 |
| Details | ANNEXIN_1 Annexin repeat signature. GSdkeaiinlItsRsnkQrqEicqnYkslygkdLiadLkyeltGkferlIvgL |
| Chain | Residue | Details |
| A | GLY37-LEU89 | |
| A | GLY109-LEU161 | |
| A | GLY193-VAL245 | |
| A | GLY268-LEU320 | |
| A | GLY380-LEU432 | |
| A | GLY452-LEU504 | |
| A | GLY616-ILE668 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P08133 |
| Chain | Residue | Details |
| A | GLU57 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P08133 |
| Chain | Residue | Details |
| A | LYS68 | |
| A | ALA592 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P08133 |
| Chain | Residue | Details |
| A | LEU85 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 9 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P08133 |
| Chain | Residue | Details |
| A | ILE118 | |
| A | THR123 | |
| A | LEU130 | |
| A | ASP136 | |
| A | GLY361 | |
| A | LEU425 | |
| A | ILE473 | |
| A | GLY538 | |
| A | LYS620 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P14824 |
| Chain | Residue | Details |
| A | PHE256 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P48037 |
| Chain | Residue | Details |
| A | TYR477 |
