1AVC

BOVINE ANNEXIN VI (CALCIUM-BOUND)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001725	cellular_component	stress fiber
A	0001786	molecular_function	phosphatidylserine binding
A	0003418	biological_process	growth plate cartilage chondrocyte differentiation
A	0005262	molecular_function	calcium channel activity
A	0005509	molecular_function	calcium ion binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006816	biological_process	calcium ion transport
A	0006937	biological_process	regulation of muscle contraction
A	0008201	molecular_function	heparin binding
A	0012506	cellular_component	vesicle membrane
A	0016020	cellular_component	membrane
A	0016192	biological_process	vesicle-mediated transport
A	0019899	molecular_function	enzyme binding
A	0030061	cellular_component	mitochondrial crista
A	0031214	biological_process	biomineral tissue development
A	0031982	cellular_component	vesicle
A	0035374	molecular_function	chondroitin sulfate binding
A	0038024	molecular_function	cargo receptor activity
A	0042470	cellular_component	melanosome
A	0042584	cellular_component	chromaffin granule membrane
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0051015	molecular_function	actin filament binding
A	0051283	biological_process	negative regulation of sequestering of calcium ion
A	0051560	biological_process	mitochondrial calcium ion homeostasis
A	0070509	biological_process	calcium ion import
A	0070588	biological_process	calcium ion transmembrane transport
A	0097190	biological_process	apoptotic signaling pathway

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 674

Chain	Residue
A	MET376
A	GLY378
A	LEU379
A	GLY380
A	THR381
A	GLU420

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 675

Chain	Residue
A	GLU83
A	LYS75
A	LEU78
A	THR79

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 676

Chain	Residue
A	MET264
A	GLY266
A	LEU267
A	GLY268
A	THR269
A	ASP308

---

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 677

Chain	Residue
A	GLY188
A	GLU189
A	LYS191
A	GLY193
A	THR194
A	SER229
A	GLU233

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 678

Chain	Residue
A	MET612
A	GLY614
A	ALA615
A	GLY616
A	THR617
A	ASP656

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 679

Chain	Residue
A	MET448
A	GLU449
A	GLY450
A	GLY452
A	ASP492

---

Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GSdkeaiinlItsRsnkQrqEicqnYkslygkdLiadLkyeltGkferlIvgL

Chain	Residue	Details
A	GLY37-LEU89
A	GLY109-LEU161
A	GLY193-VAL245
A	GLY268-LEU320
A	GLY380-LEU432
A	GLY452-LEU504
A	GLY616-ILE668

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	71
Details	Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	71
Details	Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	72
Details	Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	71
Details	Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	71
Details	Repeat: {"description":"Annexin 5","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	71
Details	Repeat: {"description":"Annexin 6","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	71
Details	Repeat: {"description":"Annexin 8","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P08133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P08133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	9
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P08133","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P14824","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48037","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---