1AUW
H91N DELTA 2 CRYSTALLIN FROM DUCK
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0004056 | molecular_function | argininosuccinate lyase activity |
| A | 0005212 | molecular_function | structural constituent of eye lens |
| A | 0005829 | cellular_component | cytosol |
| A | 0006526 | biological_process | arginine biosynthetic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016829 | molecular_function | lyase activity |
| A | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004056 | molecular_function | argininosuccinate lyase activity |
| B | 0005212 | molecular_function | structural constituent of eye lens |
| B | 0005829 | cellular_component | cytosol |
| B | 0006526 | biological_process | arginine biosynthetic process |
| B | 0008652 | biological_process | amino acid biosynthetic process |
| B | 0016829 | molecular_function | lyase activity |
| B | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| C | 0003824 | molecular_function | catalytic activity |
| C | 0004056 | molecular_function | argininosuccinate lyase activity |
| C | 0005212 | molecular_function | structural constituent of eye lens |
| C | 0005829 | cellular_component | cytosol |
| C | 0006526 | biological_process | arginine biosynthetic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016829 | molecular_function | lyase activity |
| C | 0042450 | biological_process | arginine biosynthetic process via ornithine |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004056 | molecular_function | argininosuccinate lyase activity |
| D | 0005212 | molecular_function | structural constituent of eye lens |
| D | 0005829 | cellular_component | cytosol |
| D | 0006526 | biological_process | arginine biosynthetic process |
| D | 0008652 | biological_process | amino acid biosynthetic process |
| D | 0016829 | molecular_function | lyase activity |
| D | 0042450 | biological_process | arginine biosynthetic process via ornithine |
Functional Information from PDB Data
| site_id | CAA |
| Number of Residues | 1 |
| Details | CATALYTIC HISTIDINE. |
| Chain | Residue |
| A | HIS160 |
| site_id | CAB |
| Number of Residues | 1 |
| Details | CATALYTIC HISTIDINE. |
| Chain | Residue |
| B | HIS160 |
| site_id | CAC |
| Number of Residues | 1 |
| Details | CATALYTIC HISTIDINE. |
| Chain | Residue |
| C | HIS160 |
| site_id | CAD |
| Number of Residues | 1 |
| Details | CATALYTIC HISTIDINE. |
| Chain | Residue |
| D | HIS160 |
Functional Information from PROSITE/UniProt
| site_id | PS00163 |
| Number of Residues | 10 |
| Details | FUMARATE_LYASES Fumarate lyases signature. GSslMpQKkN |
| Chain | Residue | Details |
| A | GLY280-ASN289 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:11698398 |
| Chain | Residue | Details |
| A | HIS160 | |
| B | HIS160 | |
| C | HIS160 | |
| D | HIS160 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:11698398 |
| Chain | Residue | Details |
| A | SER281 | |
| B | SER281 | |
| C | SER281 | |
| D | SER281 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:11698398, ECO:0007744|PDB:1K7W |
| Chain | Residue | Details |
| C | SER27 | |
| C | ASN114 | |
| D | SER27 | |
| D | ASN114 | |
| A | SER27 | |
| A | ASN114 | |
| B | SER27 | |
| B | ASN114 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: in chain C => ECO:0000269|PubMed:10029536, ECO:0000269|PubMed:11698398, ECO:0007744|PDB:1DCN, ECO:0007744|PDB:1K7W |
| Chain | Residue | Details |
| A | THR159 | |
| B | THR159 | |
| C | THR159 | |
| D | THR159 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | BINDING: in chain B => ECO:0000269|PubMed:10029536, ECO:0000269|PubMed:11698398, ECO:0007744|PDB:1DCN, ECO:0007744|PDB:1K7W |
| Chain | Residue | Details |
| A | ASN289 | |
| B | ASN289 | |
| C | ASN289 | |
| D | ASN289 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:10029536, ECO:0000269|PubMed:11698398, ECO:0007744|PDB:1DCN, ECO:0007744|PDB:1K7W |
| Chain | Residue | Details |
| C | TYR321 | |
| C | LYS329 | |
| D | TYR321 | |
| D | LYS329 | |
| B | TYR321 | |
| A | TYR321 | |
| A | LYS329 | |
| B | LYS329 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | BINDING: in chain A => ECO:0000269|PubMed:10029536, ECO:0007744|PDB:1DCN |
| Chain | Residue | Details |
| A | GLN326 | |
| B | GLN326 | |
| C | GLN326 | |
| D | GLN326 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 4 |
| Details | SITE: Increases basicity of active site His => ECO:0000305|PubMed:11698398 |
| Chain | Residue | Details |
| A | GLU294 | |
| B | GLU294 | |
| C | GLU294 | |
| D | GLU294 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 408 |
| Chain | Residue | Details |
| A | HIS160 | proton shuttle (general acid/base) |
| A | SER281 | proton shuttle (general acid/base) |
| A | LYS287 | electrostatic stabiliser |
| A | GLU294 | activator, proton shuttle (general acid/base) |
| site_id | MCSA2 |
| Number of Residues | 4 |
| Details | M-CSA 408 |
| Chain | Residue | Details |
| B | HIS160 | proton shuttle (general acid/base) |
| B | SER281 | proton shuttle (general acid/base) |
| B | LYS287 | electrostatic stabiliser |
| B | GLU294 | activator, proton shuttle (general acid/base) |
| site_id | MCSA3 |
| Number of Residues | 4 |
| Details | M-CSA 408 |
| Chain | Residue | Details |
| C | HIS160 | proton shuttle (general acid/base) |
| C | SER281 | proton shuttle (general acid/base) |
| C | LYS287 | electrostatic stabiliser |
| C | GLU294 | activator, proton shuttle (general acid/base) |
| site_id | MCSA4 |
| Number of Residues | 4 |
| Details | M-CSA 408 |
| Chain | Residue | Details |
| D | HIS160 | proton shuttle (general acid/base) |
| D | SER281 | proton shuttle (general acid/base) |
| D | LYS287 | electrostatic stabiliser |
| D | GLU294 | activator, proton shuttle (general acid/base) |
