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1AU1

HUMAN INTERFERON-BETA CRYSTAL STRUCTURE

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002286biological_processT cell activation involved in immune response
A0002312biological_processB cell activation involved in immune response
A0002323biological_processnatural killer cell activation involved in immune response
A0005125molecular_functioncytokine activity
A0005126molecular_functioncytokine receptor binding
A0005132molecular_functiontype I interferon receptor binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0006952biological_processdefense response
A0006959biological_processhumoral immune response
A0007166biological_processcell surface receptor signaling pathway
A0007259biological_processreceptor signaling pathway via JAK-STAT
A0008811molecular_functionchloramphenicol O-acetyltransferase activity
A0009615biological_processresponse to virus
A0010508biological_processpositive regulation of autophagy
A0019221biological_processcytokine-mediated signaling pathway
A0030101biological_processnatural killer cell activation
A0030183biological_processB cell differentiation
A0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
A0035458biological_processcellular response to interferon-beta
A0042100biological_processB cell proliferation
A0043330biological_processresponse to exogenous dsRNA
A0045071biological_processnegative regulation of viral genome replication
A0045087biological_processinnate immune response
A0045089biological_processpositive regulation of innate immune response
A0045343biological_processregulation of MHC class I biosynthetic process
A0045581biological_processnegative regulation of T cell differentiation
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0051607biological_processdefense response to virus
A0060337biological_processtype I interferon-mediated signaling pathway
A0070050biological_processneuron cellular homeostasis
A0071360biological_processcellular response to exogenous dsRNA
A0098586biological_processcellular response to virus
A0140123biological_processnegative regulation of Lewy body formation
A2000552biological_processnegative regulation of T-helper 2 cell cytokine production
A2001235biological_processpositive regulation of apoptotic signaling pathway
B0002250biological_processadaptive immune response
B0002286biological_processT cell activation involved in immune response
B0002312biological_processB cell activation involved in immune response
B0002323biological_processnatural killer cell activation involved in immune response
B0005125molecular_functioncytokine activity
B0005126molecular_functioncytokine receptor binding
B0005132molecular_functiontype I interferon receptor binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0006952biological_processdefense response
B0006959biological_processhumoral immune response
B0007166biological_processcell surface receptor signaling pathway
B0007259biological_processreceptor signaling pathway via JAK-STAT
B0008811molecular_functionchloramphenicol O-acetyltransferase activity
B0009615biological_processresponse to virus
B0010508biological_processpositive regulation of autophagy
B0019221biological_processcytokine-mediated signaling pathway
B0030101biological_processnatural killer cell activation
B0030183biological_processB cell differentiation
B0033141biological_processpositive regulation of peptidyl-serine phosphorylation of STAT protein
B0035458biological_processcellular response to interferon-beta
B0042100biological_processB cell proliferation
B0043330biological_processresponse to exogenous dsRNA
B0045071biological_processnegative regulation of viral genome replication
B0045087biological_processinnate immune response
B0045089biological_processpositive regulation of innate immune response
B0045343biological_processregulation of MHC class I biosynthetic process
B0045581biological_processnegative regulation of T cell differentiation
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0051607biological_processdefense response to virus
B0060337biological_processtype I interferon-mediated signaling pathway
B0070050biological_processneuron cellular homeostasis
B0071360biological_processcellular response to exogenous dsRNA
B0098586biological_processcellular response to virus
B0140123biological_processnegative regulation of Lewy body formation
B2000552biological_processnegative regulation of T-helper 2 cell cytokine production
B2001235biological_processpositive regulation of apoptotic signaling pathway
Functional Information from PROSITE/UniProt
site_idPS00252
Number of Residues19
DetailsINTERFERON_A_B_D Interferon alpha, beta and delta family signature. YYgRIlhYLkakeyshCAW
ChainResidueDetails
ATYR125-TRP143

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsMOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P70499
ChainResidueDetails
ATYR3
BTYR3

site_idSWS_FT_FI2
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:9342320
ChainResidueDetails
AASN80
BASN80

217705

PDB entries from 2024-03-27

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