Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004783 | molecular_function | sulfite reductase (NADPH) activity |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009337 | cellular_component | sulfite reductase complex (NADPH) |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0020037 | molecular_function | heme binding |
| A | 0050661 | molecular_function | NADP binding |
| A | 0051536 | molecular_function | iron-sulfur cluster binding |
| A | 0051539 | molecular_function | 4 iron, 4 sulfur cluster binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE PO4 A 585 |
| Chain | Residue |
| A | LYS217 |
| A | SRM580 |
| A | HOH709 |
| A | ARG83 |
| A | ARG117 |
| A | ARG153 |
| A | LYS215 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE K A 590 |
| Chain | Residue |
| A | ILE362 |
| A | ASN395 |
| A | GLN396 |
| A | ASN397 |
| A | HOH640 |
| A | HOH642 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SF4 A 575 |
| Chain | Residue |
| A | CYS434 |
| A | CYS440 |
| A | ALA443 |
| A | THR477 |
| A | CYS479 |
| A | ASN481 |
| A | CYS483 |
| A | SRM580 |
| site_id | AC4 |
| Number of Residues | 41 |
| Details | BINDING SITE FOR RESIDUE SRM A 580 |
| Chain | Residue |
| A | ARG83 |
| A | ARG113 |
| A | THR115 |
| A | ASN116 |
| A | ARG117 |
| A | THR119 |
| A | GLN121 |
| A | HIS123 |
| A | ARG214 |
| A | LYS215 |
| A | LYS217 |
| A | GLY256 |
| A | LEU257 |
| A | SER258 |
| A | GLN396 |
| A | ALA433 |
| A | CYS434 |
| A | VAL435 |
| A | THR439 |
| A | CYS440 |
| A | PRO441 |
| A | ASN481 |
| A | GLY482 |
| A | CYS483 |
| A | ARG485 |
| A | SF4575 |
| A | PO4585 |
| A | HOH607 |
| A | HOH694 |
| A | HOH695 |
| A | HOH717 |
| A | HOH743 |
| A | HOH771 |
| A | HOH772 |
| A | HOH773 |
| A | HOH774 |
| A | HOH827 |
| A | HOH832 |
| A | HOH887 |
| A | HOH901 |
| A | HOH966 |
| site_id | ACT |
| Number of Residues | 4 |
| Details | FOUR ACTIVE SITE RESIDUES THAT CONTACT THE BOUND PHOSPHATE. |
| Chain | Residue |
| A | ARG83 |
| A | ARG153 |
| A | LYS215 |
| A | LYS217 |
| site_id | BRG |
| Number of Residues | 1 |
| Details | CYSTEINE THIOLATE IN THE ACTIVE CENTER THAT BRIDGES THE HEME IRON TO THE [4FE-4S] CLUSTER. |
Functional Information from PROSITE/UniProt
| site_id | PS00365 |
| Number of Residues | 17 |
| Details | NIR_SIR Nitrite and sulfite reductases iron-sulfur/siroheme-binding site. TGCpngCgramlaEVGL |
| Chain | Residue | Details |
| A | THR477-LEU493 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"7569952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9315848","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"7569952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"9315848","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 5 |
| Details | a catalytic site defined by CSA, PubMed 9315848, 7569952, 10984484, 9315849, 15966732 |
| Chain | Residue | Details |
| A | LYS215 | |
| A | ARG83 | |
| A | CYS483 | |
| A | LYS217 | |
| A | ARG153 | |
| site_id | MCSA1 |
| Number of Residues | 8 |
| Details | M-CSA 398 |
| Chain | Residue | Details |
| A | ARG83 | activator |
| A | ARG153 | activator |
| A | LYS215 | activator |
| A | LYS217 | activator |
| A | CYS434 | metal ligand |
| A | CYS440 | metal ligand |
| A | CYS479 | metal ligand |
| A | CYS483 | electron shuttle, metal ligand |
