Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1ANX

THE CRYSTAL STRUCTURE OF A NEW HIGH-CALCIUM FORM OF ANNEXIN V

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001786	molecular_function	phosphatidylserine binding
A	0004859	molecular_function	phospholipase inhibitor activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005543	molecular_function	phospholipid binding
A	0005544	molecular_function	calcium-dependent phospholipid binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005925	cellular_component	focal adhesion
A	0007165	biological_process	signal transduction
A	0009897	cellular_component	external side of plasma membrane
A	0012506	cellular_component	vesicle membrane
A	0016020	cellular_component	membrane
A	0031012	cellular_component	extracellular matrix
A	0042383	cellular_component	sarcolemma
A	0043066	biological_process	negative regulation of apoptotic process
A	0050819	biological_process	negative regulation of coagulation
A	0070062	cellular_component	extracellular exosome
A	0072563	cellular_component	endothelial microparticle
B	0001786	molecular_function	phosphatidylserine binding
B	0004859	molecular_function	phospholipase inhibitor activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005543	molecular_function	phospholipid binding
B	0005544	molecular_function	calcium-dependent phospholipid binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005925	cellular_component	focal adhesion
B	0007165	biological_process	signal transduction
B	0009897	cellular_component	external side of plasma membrane
B	0012506	cellular_component	vesicle membrane
B	0016020	cellular_component	membrane
B	0031012	cellular_component	extracellular matrix
B	0042383	cellular_component	sarcolemma
B	0043066	biological_process	negative regulation of apoptotic process
B	0050819	biological_process	negative regulation of coagulation
B	0070062	cellular_component	extracellular exosome
B	0072563	cellular_component	endothelial microparticle
C	0001786	molecular_function	phosphatidylserine binding
C	0004859	molecular_function	phospholipase inhibitor activity
C	0005509	molecular_function	calcium ion binding
C	0005515	molecular_function	protein binding
C	0005543	molecular_function	phospholipid binding
C	0005544	molecular_function	calcium-dependent phospholipid binding
C	0005576	cellular_component	extracellular region
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005925	cellular_component	focal adhesion
C	0007165	biological_process	signal transduction
C	0009897	cellular_component	external side of plasma membrane
C	0012506	cellular_component	vesicle membrane
C	0016020	cellular_component	membrane
C	0031012	cellular_component	extracellular matrix
C	0042383	cellular_component	sarcolemma
C	0043066	biological_process	negative regulation of apoptotic process
C	0050819	biological_process	negative regulation of coagulation
C	0070062	cellular_component	extracellular exosome
C	0072563	cellular_component	endothelial microparticle

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 321

Chain	Residue
A	GLY183
A	LYS186
A	GLY188
A	GLU228
A	SO4322
A	HOH326

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE SO4 A 322

Chain	Residue
A	THR189
A	GLU228
A	CA321
A	HOH339
A	HOH420
A	HOH449
B	GLN181
A	LYS186
A	TRP187
A	GLY188

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 323

Chain	Residue
A	MET28
A	GLY30
A	GLY32
A	GLU72

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 324

Chain	Residue
A	LYS70
A	LEU73
A	GLU78

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA A 325

Chain	Residue
A	ASP226
A	THR229
A	GLU234

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA B 321

Chain	Residue
B	GLY183
B	LYS186
B	GLY188
B	GLU228
B	SO4322
B	HOH345

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE SO4 B 322

Chain	Residue
B	LYS186
B	GLY188
B	THR189
B	GLU228
B	CA321
B	HOH345
B	HOH362
B	HOH382
C	GLN181

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA B 323

Chain	Residue
B	MET28
B	GLY30
B	GLY32
B	GLU72
B	HOH441

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA B 324

Chain	Residue
B	LYS70
B	LEU73
B	GLU78
B	HOH455

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA B 325

Chain	Residue
B	ASP226
B	THR229
B	GLU234

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 321

Chain	Residue
C	GLY183
C	LYS186
C	GLY188
C	GLU228
C	SO4322
C	HOH333

site_id	BC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 C 322

Chain	Residue
A	GLN181
C	LYS186
C	TRP187
C	GLY188
C	THR189
C	GLU228
C	CA321
C	HOH441

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA C 323

Chain	Residue
C	MET28
C	GLY30
C	GLY32
C	GLU72
C	HOH385

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 324

Chain	Residue
C	LYS70
C	LEU73
C	GLU78

site_id	BC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CA C 325

Chain	Residue
C	ASP226
C	THR229
C	GLU234

Functional Information from PROSITE/UniProt

site_id	PS00223
Number of Residues	53
Details	ANNEXIN_1 Annexin repeat signature. GTdeesiltlLtsRsnaQrqEisaaFktlfgrdLlddLkseltGkfeklIvaL

Chain	Residue	Details
A	GLY32-LEU84
A	GLY104-LEU156
A	GLY188-VAL240
A	GLY263-LEU315

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	213
Details	Repeat: {"description":"Annexin 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	213
Details	Repeat: {"description":"Annexin 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	216
Details	Repeat: {"description":"Annexin 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	213
Details	Repeat: {"description":"Annexin 4","evidences":[{"source":"PROSITE-ProRule","id":"PRU01245","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P48036","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	3
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"16916647","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"P48036","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25772364","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)