1AKZ

HUMAN URACIL-DNA GLYCOSYLASE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004844	molecular_function	uracil DNA N-glycosylase activity
A	0006281	biological_process	DNA repair
A	0006284	biological_process	base-excision repair
A	0016799	molecular_function	hydrolase activity, hydrolyzing N-glycosyl compounds

Functional Information from PROSITE/UniProt

site_id	PS00130
Number of Residues	10
Details	U_DNA_GLYCOSYLASE Uracil-DNA glycosylase signature. KVVIlGQDPY

Chain	Residue	Details
A	LYS138-TYR147

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03166, ECO:0000269|PubMed:9724657, ECO:0000312|PDB:1SSP

Chain	Residue	Details
A	HIS154

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:8900285, ECO:0000269|PubMed:9724657, ECO:0000312|PDB:1SSP, ECO:0000312|PDB:4SKN

Chain	Residue	Details
A	ALA153
A	PRO167
A	GLN213
A	GLY277

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:8900285, ECO:0000312|PDB:4SKN

Chain	Residue	Details
A	CYS157
A	SER178
A	ILE256
A	PHE279
A	ARG282
A	SER285

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	SITE: Essential for UNG2 recruitment to nuclear foci => ECO:0000269|PubMed:22521144

Chain	Residue	Details
A	SER88

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
A	GLY295

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1eug

Chain	Residue	Details
A	ASP145
A	HIS268

---