Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0050661 | molecular_function | NADP binding |
| B | 0004146 | molecular_function | dihydrofolate reductase activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046452 | biological_process | dihydrofolate metabolic process |
| B | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| B | 0046655 | biological_process | folic acid metabolic process |
| B | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | BINDING SITE FOR RESIDUE NDP A 193 |
| Chain | Residue |
| A | VAL10 |
| A | ARG56 |
| A | LYS57 |
| A | THR58 |
| A | LEU77 |
| A | SER78 |
| A | ARG79 |
| A | SER94 |
| A | ILE112 |
| A | GLY114 |
| A | ALA115 |
| A | ALA11 |
| A | GLU116 |
| A | ILE117 |
| A | TYR118 |
| A | GLU120 |
| A | HOH360 |
| A | ILE19 |
| A | GLY23 |
| A | LYS24 |
| A | MET25 |
| A | ARG30 |
| A | LYS31 |
| A | GLY55 |
| site_id | AC2 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NDP B 193 |
| Chain | Residue |
| B | ALA11 |
| B | ILE19 |
| B | GLY20 |
| B | LYS22 |
| B | GLY23 |
| B | LYS24 |
| B | MET25 |
| B | GLY55 |
| B | ARG56 |
| B | LYS57 |
| B | THR58 |
| B | LEU77 |
| B | SER78 |
| B | ARG79 |
| B | SER94 |
| B | SER95 |
| B | ILE112 |
| B | GLY114 |
| B | ALA115 |
| B | GLU116 |
| B | ILE117 |
| B | TYR118 |
| B | GLU120 |
| B | HOH231 |
| B | HOH322 |
| B | HOH323 |
| B | HOH343 |
| B | HOH350 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. GIGykgkMPWrlrk.EiryFkdvT |
| Chain | Residue | Details |
| A | GLY18-THR40 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 372 |
| Details | Domain: {"description":"DHFR","evidences":[{"source":"PROSITE-ProRule","id":"PRU00660","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 36 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11520201","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11520201","evidenceCode":"ECO:0000305"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"UniProtKB","id":"P0ABQ4","evidenceCode":"ECO:0000250"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1ra2 |
| Chain | Residue | Details |
| A | VAL10 | |
| A | GLU32 | |
| A | ILE33 | |
| A | MET25 | |
| A | ILE112 | |
| A | LEU69 | |
| A | PHE36 | |
| site_id | CSA2 |
| Number of Residues | 7 |
| Details | Annotated By Reference To The Literature 1ra2 |
| Chain | Residue | Details |
| B | VAL10 | |
| B | GLU32 | |
| B | ILE33 | |
| B | MET25 | |
| B | ILE112 | |
| B | LEU69 | |
| B | PHE36 | |
