1AB8
RAT TYPE II ADENYLYL CYCLASE C2 DOMAIN/FORSKOLIN COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| A | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| A | 0035556 | biological_process | intracellular signal transduction |
| B | 0009190 | biological_process | cyclic nucleotide biosynthetic process |
| B | 0016849 | molecular_function | phosphorus-oxygen lyase activity |
| B | 0035556 | biological_process | intracellular signal transduction |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FOK A 1 |
| Chain | Residue |
| A | PHE889 |
| B | LEU915 |
| B | ILE940 |
| B | GLY941 |
| B | SER942 |
| A | MET945 |
| A | ASP1018 |
| A | ILE1019 |
| A | TRP1020 |
| A | GLY1021 |
| A | VAL1024 |
| A | ASN1025 |
| B | LYS896 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE FOK B 2 |
| Chain | Residue |
| A | HOH6 |
| A | LYS896 |
| A | ILE940 |
| A | GLY941 |
| A | SER942 |
| B | PHE889 |
| B | MET945 |
| B | ASP1018 |
| B | ILE1019 |
| B | TRP1020 |
| B | GLY1021 |
| B | VAL1024 |
| B | ASN1025 |
Functional Information from PROSITE/UniProt
| site_id | PS00452 |
| Number of Residues | 24 |
| Details | GUANYLATE_CYCLASE_1 Guanylate cyclase signature. GVI.GaqkpqYdIWGNTVNvasrmD |
| Chain | Residue | Details |
| A | GLY1008-ASP1031 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 40 |
| Details | Region: {"description":"Interaction with GNAS","evidences":[{"source":"PubMed","id":"11087399","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10427002","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"11087399","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15591060","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16766715","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"19243146","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"10427002","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1CJK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3MAA","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | a catalytic site defined by CSA, PubMed 9139678 |
| Chain | Residue | Details |
| A | ARG1029 |
| site_id | MCSA1 |
| Number of Residues | 1 |
| Details | M-CSA 58 |
| Chain | Residue | Details |
| A | ARG1029 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 1 |
| Details | M-CSA 58 |
| Chain | Residue | Details |
| B | ARG1029 | electrostatic stabiliser |
