1A81

CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0007166	biological_process	cell surface receptor signaling pathway
B	0016020	cellular_component	membrane
C	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0007166	biological_process	cell surface receptor signaling pathway
D	0016020	cellular_component	membrane
E	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0007166	biological_process	cell surface receptor signaling pathway
F	0016020	cellular_component	membrane
G	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0007166	biological_process	cell surface receptor signaling pathway
H	0016020	cellular_component	membrane
I	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0007166	biological_process	cell surface receptor signaling pathway
J	0016020	cellular_component	membrane
K	0004715	molecular_function	non-membrane spanning protein tyrosine kinase activity
L	0004888	molecular_function	transmembrane signaling receptor activity
L	0007166	biological_process	cell surface receptor signaling pathway
L	0016020	cellular_component	membrane

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000255|PROSITE-ProRule:PRU00379, ECO:0000269|PubMed:9698567, ECO:0007744|PubMed:15592455, ECO:0007744|PubMed:19690332

Chain	Residue	Details
B	PTR170
D	PTR170
F	PTR170
H	PTR170
J	PTR170
L	PTR170

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site_id	SWS_FT_FI2
Number of Residues	6
Details	MOD_RES: Phosphotyrosine => ECO:0000255|PROSITE-ProRule:PRU00379, ECO:0000269|PubMed:9698567

Chain	Residue	Details
G	SER44
G	SER202
I	SER44
I	SER202
K	SER44
K	SER202
B	PTR181
D	PTR181
F	PTR181
H	PTR181
J	PTR181
L	PTR181

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site_id	SWS_FT_FI3
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0000269|PubMed:21469132

Chain	Residue	Details
A	TYR47
A	TYR131
G	TYR47
G	TYR131
I	TYR47
I	TYR131
K	TYR47
K	TYR131
C	TYR47
C	TYR131
E	TYR47
E	TYR131

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site_id	SWS_FT_FI4
Number of Residues	6
Details	MOD_RES: Phosphothreonine => ECO:0000269|PubMed:21469132

Chain	Residue	Details
A	THR256
C	THR256
E	THR256
G	THR256
I	THR256
K	THR256

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