1A81
CRYSTAL STRUCTURE OF THE TANDEM SH2 DOMAIN OF THE SYK KINASE BOUND TO A DUALLY TYROSINE-PHOSPHORYLATED ITAM
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0016020 | cellular_component | membrane |
| C | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0007166 | biological_process | cell surface receptor signaling pathway |
| D | 0016020 | cellular_component | membrane |
| E | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0007166 | biological_process | cell surface receptor signaling pathway |
| F | 0016020 | cellular_component | membrane |
| G | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0007166 | biological_process | cell surface receptor signaling pathway |
| H | 0016020 | cellular_component | membrane |
| I | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0007166 | biological_process | cell surface receptor signaling pathway |
| J | 0016020 | cellular_component | membrane |
| K | 0004715 | molecular_function | non-membrane spanning protein tyrosine kinase activity |
| L | 0004888 | molecular_function | transmembrane signaling receptor activity |
| L | 0007166 | biological_process | cell surface receptor signaling pathway |
| L | 0016020 | cellular_component | membrane |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 552 |
| Details | Domain: {"description":"SH2 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 546 |
| Details | Domain: {"description":"SH2 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00191","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 177 |
| Details | Region: {"description":"Interdomain A"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 12 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"21469132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
