Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000122 | biological_process | negative regulation of transcription by RNA polymerase II |
| A | 0000978 | molecular_function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0003697 | molecular_function | single-stranded DNA binding |
| A | 0003729 | molecular_function | mRNA binding |
| A | 0004177 | molecular_function | aminopeptidase activity |
| A | 0004197 | molecular_function | cysteine-type endopeptidase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0006508 | biological_process | proteolysis |
| A | 0008233 | molecular_function | peptidase activity |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| A | 0009636 | biological_process | response to toxic substance |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043418 | biological_process | homocysteine catabolic process |
| A | 0046677 | biological_process | response to antibiotic |
| A | 0070005 | molecular_function | cysteine-type aminopeptidase activity |
Functional Information from PDB Data
| site_id | A73 |
| Number of Residues | 1 |
| Details | NUCLEOPHILIC CYSTEINE MUTATED TO ALANINE. |
| site_id | AC1 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1101 |
| Chain | Residue |
| A | HOH754 |
| A | HOH809 |
| A | HOH810 |
| A | ASN66 |
| A | GLY395 |
| A | LYS396 |
| A | HOH749 |
| A | HOH751 |
| A | HOH753 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1102 |
| Chain | Residue |
| A | ILE126 |
| A | ARG192 |
| A | LYS196 |
| A | TYR362 |
| A | HOH570 |
| A | HOH703 |
| A | HOH704 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1103 |
| Chain | Residue |
| A | ASN273 |
| A | TYR279 |
| A | ASP303 |
| A | ASN304 |
| A | HOH553 |
| A | HOH655 |
| A | HOH656 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1104 |
| Chain | Residue |
| A | ASN34 |
| A | TYR168 |
| A | ARG174 |
| A | HOH532 |
| A | HOH746 |
| A | HOH747 |
| A | HOH760 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1105 |
| Chain | Residue |
| A | ARG174 |
| A | LYS175 |
| A | SER178 |
| A | LYS329 |
| A | HOH546 |
| A | HOH817 |
| site_id | AC6 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1106 |
| Chain | Residue |
| A | ARG44 |
| A | HOH699 |
| site_id | NUL |
| Number of Residues | 2 |
| Details | CATALYTIC RESIDUES. |
| Chain | Residue |
| A | HIS369 |
| A | ASN392 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. MTHAMLITGCH |
| Chain | Residue | Details |
| A | MET367-HIS377 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Propeptide: {"description":"Removed in mature form; by autocatalysis","featureId":"PRO_0000292865","evidences":[{"source":"PubMed","id":"7638617","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1gcb |
| Chain | Residue | Details |
| A | ASN392 | |
| A | ALA73 | |
| A | HIS369 | |
| A | GLN67 | |
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 624 |
| Chain | Residue | Details |
| A | GLN67 | electrostatic stabiliser |
| A | ALA73 | electrostatic stabiliser, nucleofuge, nucleophile, proton acceptor, proton donor |
| A | HIS369 | proton acceptor, proton donor |
| A | ASN392 | electrostatic stabiliser |
