1A6Q

CRYSTAL STRUCTURE OF THE PROTEIN SERINE/THREONINE PHOSPHATASE 2C AT 2 A RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000287	molecular_function	magnesium ion binding
A	0004721	molecular_function	phosphoprotein phosphatase activity
A	0004722	molecular_function	protein serine/threonine phosphatase activity
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006470	biological_process	protein dephosphorylation
A	0006499	biological_process	N-terminal protein myristoylation
A	0006611	biological_process	protein export from nucleus
A	0016020	cellular_component	membrane
A	0016311	biological_process	dephosphorylation
A	0017018	molecular_function	myosin phosphatase activity
A	0030145	molecular_function	manganese ion binding
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0030514	biological_process	negative regulation of BMP signaling pathway
A	0033192	molecular_function	calmodulin-dependent protein phosphatase activity
A	0035970	biological_process	peptidyl-threonine dephosphorylation
A	0043123	biological_process	positive regulation of canonical NF-kappaB signal transduction
A	0043124	biological_process	negative regulation of canonical NF-kappaB signal transduction
A	0043169	molecular_function	cation binding
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0046872	molecular_function	metal ion binding
A	0051726	biological_process	regulation of cell cycle
A	0070412	molecular_function	R-SMAD binding
A	0071560	biological_process	cellular response to transforming growth factor beta stimulus
A	0090263	biological_process	positive regulation of canonical Wnt signaling pathway
A	1901223	biological_process	negative regulation of non-canonical NF-kappaB signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MN A 383

Chain	Residue
A	ASP282
A	PO4701
A	HOH799
A	HOH880
A	HOH889
A	ASP60
A	ASP239

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MN A 384

Chain	Residue
A	ASP60
A	GLY61
A	HOH702
A	HOH800
A	HOH879
A	HOH880

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site_id	AC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE PO4 A 701

Chain	Residue
A	ARG33
A	ASP282
A	LYS303
A	MN383
A	HOH702
A	HOH776
A	HOH799
A	HOH800
A	HOH802
A	HOH880

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site_id	MN2
Number of Residues	7
Details	MN 2+ BINDING SITES.

Chain	Residue
A	ASP38
A	ASP60
A	ASP282
A	ASP239
A	ARG33
A	GLU37
A	GLY61

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Functional Information from PROSITE/UniProt

site_id	PS01032
Number of Residues	9
Details	PPM_1 PPM-type phosphatase domain signature. FFAVYDGHA

Chain	Residue	Details
A	PHE55-ALA63

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:9003755, ECO:0007744|PDB:1A6Q

Chain	Residue	Details
A	ASP282
A	ASP60
A	GLY61
A	ASP239

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332

Chain	Residue	Details
A	SER375

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P49443

Chain	Residue	Details
A	SER377

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site_id	SWS_FT_FI4
Number of Residues	1
Details	LIPID: N-myristoyl glycine => ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805

Chain	Residue	Details
A	GLY2

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