Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1A4Z

ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA COMPLEX WITH NAD (REDUCED) AND SAMARIUM (III)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0006067	biological_process	ethanol metabolic process
A	0006068	biological_process	ethanol catabolic process
A	0008957	molecular_function	phenylacetaldehyde dehydrogenase (NAD+) activity
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0018937	biological_process	nitroglycerin metabolic process
A	0046185	biological_process	aldehyde catabolic process
A	0051287	molecular_function	NAD binding
A	0106435	molecular_function	carboxylesterase activity
A	0110095	biological_process	cellular detoxification of aldehyde
A	1903179	biological_process	regulation of dopamine biosynthetic process
A	1905627	biological_process	regulation of serotonin biosynthetic process
B	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0006067	biological_process	ethanol metabolic process
B	0006068	biological_process	ethanol catabolic process
B	0008957	molecular_function	phenylacetaldehyde dehydrogenase (NAD+) activity
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0018937	biological_process	nitroglycerin metabolic process
B	0046185	biological_process	aldehyde catabolic process
B	0051287	molecular_function	NAD binding
B	0106435	molecular_function	carboxylesterase activity
B	0110095	biological_process	cellular detoxification of aldehyde
B	1903179	biological_process	regulation of dopamine biosynthetic process
B	1905627	biological_process	regulation of serotonin biosynthetic process
C	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0006067	biological_process	ethanol metabolic process
C	0006068	biological_process	ethanol catabolic process
C	0008957	molecular_function	phenylacetaldehyde dehydrogenase (NAD+) activity
C	0016491	molecular_function	oxidoreductase activity
C	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
C	0018937	biological_process	nitroglycerin metabolic process
C	0046185	biological_process	aldehyde catabolic process
C	0051287	molecular_function	NAD binding
C	0106435	molecular_function	carboxylesterase activity
C	0110095	biological_process	cellular detoxification of aldehyde
C	1903179	biological_process	regulation of dopamine biosynthetic process
C	1905627	biological_process	regulation of serotonin biosynthetic process
D	0004029	molecular_function	aldehyde dehydrogenase (NAD+) activity
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0006067	biological_process	ethanol metabolic process
D	0006068	biological_process	ethanol catabolic process
D	0008957	molecular_function	phenylacetaldehyde dehydrogenase (NAD+) activity
D	0016491	molecular_function	oxidoreductase activity
D	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
D	0018937	biological_process	nitroglycerin metabolic process
D	0046185	biological_process	aldehyde catabolic process
D	0051287	molecular_function	NAD binding
D	0106435	molecular_function	carboxylesterase activity
D	0110095	biological_process	cellular detoxification of aldehyde
D	1903179	biological_process	regulation of dopamine biosynthetic process
D	1905627	biological_process	regulation of serotonin biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SM A 502

Chain	Residue
A	NAD501
A	HOH514

site_id	AC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SM B 502

Chain	Residue
B	NAD501
B	HOH514

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SM C 502

Chain	Residue
C	NAD501
C	HOH511

site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SM D 502

Chain	Residue
D	NAD501
D	HOH512

site_id	AC5
Number of Residues	28
Details	BINDING SITE FOR RESIDUE NAD A 501

Chain	Residue
A	ILE166
A	PRO167
A	TRP168
A	ASN169
A	MET174
A	LYS192
A	GLU195
A	GLY225
A	PRO226
A	GLY229
A	ALA230
A	PHE243
A	THR244
A	GLY245
A	SER246
A	VAL249
A	LEU252
A	ILE253
A	GLU268
A	ILE269
A	GLY270
A	CYS302
A	GLU399
A	PHE401
A	SM502
A	HOH513
A	HOH514
A	ILE165

site_id	AC6
Number of Residues	26
Details	BINDING SITE FOR RESIDUE NAD B 501

Chain	Residue
B	ILE165
B	ILE166
B	PRO167
B	TRP168
B	ASN169
B	LYS192
B	GLU195
B	GLY225
B	GLY229
B	ALA230
B	PHE243
B	THR244
B	GLY245
B	SER246
B	VAL249
B	LEU252
B	GLU268
B	ILE269
B	GLY270
B	CYS302
B	GLU399
B	PHE401
B	SM502
B	HOH513
B	HOH514
B	HOH517

site_id	AC7
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD C 501

Chain	Residue
C	ILE165
C	ILE166
C	PRO167
C	TRP168
C	ASN169
C	LYS192
C	ALA194
C	GLU195
C	GLY225
C	PRO226
C	GLY229
C	ALA230
C	PHE243
C	THR244
C	GLY245
C	SER246
C	VAL249
C	ILE253
C	GLU268
C	ILE269
C	GLY270
C	CYS302
C	GLU399
C	PHE401
C	SM502
C	HOH510
C	HOH511

site_id	AC8
Number of Residues	27
Details	BINDING SITE FOR RESIDUE NAD D 501

Chain	Residue
D	GLY229
D	ALA230
D	PHE243
D	THR244
D	GLY245
D	SER246
D	VAL249
D	ILE253
D	GLU268
D	ILE269
D	GLY270
D	CYS302
D	GLU399
D	PHE401
D	SM502
D	HOH511
D	HOH512
D	ILE165
D	ILE166
D	PRO167
D	TRP168
D	ASN169
D	LYS192
D	ALA194
D	GLU195
D	GLY225
D	PRO226

Functional Information from PROSITE/UniProt

site_id	PS00070
Number of Residues	12
Details	ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCCAGS

Chain	Residue	Details
A	PHE295-SER306

site_id	PS00687
Number of Residues	8
Details	ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LEIGGKSP

Chain	Residue	Details
A	LEU267-PRO274

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"9195888","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"9195888","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	56
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9195888","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1A4Z","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"9195888","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	40
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P47738","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS302
A	GLU268
A	ASN169

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	CYS302
B	GLU268
B	ASN169

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	CYS302
C	GLU268
C	ASN169

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	CYS302
D	GLU268
D	ASN169

site_id	CSA5
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
A	CYS302
A	LYS192
A	GLU268
A	GLU399

site_id	CSA6
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
B	CYS302
B	LYS192
B	GLU268
B	GLU399

site_id	CSA7
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
C	CYS302
C	LYS192
C	GLU268
C	GLU399

site_id	CSA8
Number of Residues	4
Details	Annotated By Reference To The Literature 1a4s

Chain	Residue	Details
D	CYS302
D	LYS192
D	GLU268
D	GLU399

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)