1A4Z
ALDEHYDE DEHYDROGENASE FROM BOVINE MITOCHONDRIA COMPLEX WITH NAD (REDUCED) AND SAMARIUM (III)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006068 | biological_process | ethanol catabolic process |
| A | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| A | 0018547 | molecular_function | nitroglycerin reductase activity |
| A | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| A | 0046185 | biological_process | aldehyde catabolic process |
| A | 0051287 | molecular_function | NAD binding |
| A | 0106435 | molecular_function | carboxylesterase activity |
| A | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| A | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| B | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006068 | biological_process | ethanol catabolic process |
| B | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| B | 0018547 | molecular_function | nitroglycerin reductase activity |
| B | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| B | 0046185 | biological_process | aldehyde catabolic process |
| B | 0051287 | molecular_function | NAD binding |
| B | 0106435 | molecular_function | carboxylesterase activity |
| B | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| B | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| C | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| C | 0005739 | cellular_component | mitochondrion |
| C | 0005759 | cellular_component | mitochondrial matrix |
| C | 0006068 | biological_process | ethanol catabolic process |
| C | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| C | 0018547 | molecular_function | nitroglycerin reductase activity |
| C | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| C | 0046185 | biological_process | aldehyde catabolic process |
| C | 0051287 | molecular_function | NAD binding |
| C | 0106435 | molecular_function | carboxylesterase activity |
| C | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| C | 1905627 | biological_process | regulation of serotonin biosynthetic process |
| D | 0004029 | molecular_function | aldehyde dehydrogenase (NAD+) activity |
| D | 0005739 | cellular_component | mitochondrion |
| D | 0005759 | cellular_component | mitochondrial matrix |
| D | 0006068 | biological_process | ethanol catabolic process |
| D | 0008957 | molecular_function | phenylacetaldehyde dehydrogenase activity |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0016620 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor |
| D | 0018547 | molecular_function | nitroglycerin reductase activity |
| D | 0043878 | molecular_function | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity |
| D | 0046185 | biological_process | aldehyde catabolic process |
| D | 0051287 | molecular_function | NAD binding |
| D | 0106435 | molecular_function | carboxylesterase activity |
| D | 1903179 | biological_process | regulation of dopamine biosynthetic process |
| D | 1905627 | biological_process | regulation of serotonin biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SM A 502 |
| Chain | Residue |
| A | NAD501 |
| A | HOH514 |
| site_id | AC2 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SM B 502 |
| Chain | Residue |
| B | NAD501 |
| B | HOH514 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SM C 502 |
| Chain | Residue |
| C | NAD501 |
| C | HOH511 |
| site_id | AC4 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE SM D 502 |
| Chain | Residue |
| D | NAD501 |
| D | HOH512 |
| site_id | AC5 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE NAD A 501 |
| Chain | Residue |
| A | ILE166 |
| A | PRO167 |
| A | TRP168 |
| A | ASN169 |
| A | MET174 |
| A | LYS192 |
| A | GLU195 |
| A | GLY225 |
| A | PRO226 |
| A | GLY229 |
| A | ALA230 |
| A | PHE243 |
| A | THR244 |
| A | GLY245 |
| A | SER246 |
| A | VAL249 |
| A | LEU252 |
| A | ILE253 |
| A | GLU268 |
| A | ILE269 |
| A | GLY270 |
| A | CYS302 |
| A | GLU399 |
| A | PHE401 |
| A | SM502 |
| A | HOH513 |
| A | HOH514 |
| A | ILE165 |
| site_id | AC6 |
| Number of Residues | 26 |
| Details | BINDING SITE FOR RESIDUE NAD B 501 |
| Chain | Residue |
| B | ILE165 |
| B | ILE166 |
| B | PRO167 |
| B | TRP168 |
| B | ASN169 |
| B | LYS192 |
| B | GLU195 |
| B | GLY225 |
| B | GLY229 |
| B | ALA230 |
| B | PHE243 |
| B | THR244 |
| B | GLY245 |
| B | SER246 |
| B | VAL249 |
| B | LEU252 |
| B | GLU268 |
| B | ILE269 |
| B | GLY270 |
| B | CYS302 |
| B | GLU399 |
| B | PHE401 |
| B | SM502 |
| B | HOH513 |
| B | HOH514 |
| B | HOH517 |
| site_id | AC7 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD C 501 |
| Chain | Residue |
| C | ILE165 |
| C | ILE166 |
| C | PRO167 |
| C | TRP168 |
| C | ASN169 |
| C | LYS192 |
| C | ALA194 |
| C | GLU195 |
| C | GLY225 |
| C | PRO226 |
| C | GLY229 |
| C | ALA230 |
| C | PHE243 |
| C | THR244 |
| C | GLY245 |
| C | SER246 |
| C | VAL249 |
| C | ILE253 |
| C | GLU268 |
| C | ILE269 |
| C | GLY270 |
| C | CYS302 |
| C | GLU399 |
| C | PHE401 |
| C | SM502 |
| C | HOH510 |
| C | HOH511 |
| site_id | AC8 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NAD D 501 |
| Chain | Residue |
| D | GLY229 |
| D | ALA230 |
| D | PHE243 |
| D | THR244 |
| D | GLY245 |
| D | SER246 |
| D | VAL249 |
| D | ILE253 |
| D | GLU268 |
| D | ILE269 |
| D | GLY270 |
| D | CYS302 |
| D | GLU399 |
| D | PHE401 |
| D | SM502 |
| D | HOH511 |
| D | HOH512 |
| D | ILE165 |
| D | ILE166 |
| D | PRO167 |
| D | TRP168 |
| D | ASN169 |
| D | LYS192 |
| D | ALA194 |
| D | GLU195 |
| D | GLY225 |
| D | PRO226 |
Functional Information from PROSITE/UniProt
| site_id | PS00070 |
| Number of Residues | 12 |
| Details | ALDEHYDE_DEHYDR_CYS Aldehyde dehydrogenases cysteine active site. FfNQGQCCCAGS |
| Chain | Residue | Details |
| A | PHE295-SER306 |
| site_id | PS00687 |
| Number of Residues | 8 |
| Details | ALDEHYDE_DEHYDR_GLU Aldehyde dehydrogenases glutamic acid active site. LEIGGKSP |
| Chain | Residue | Details |
| A | LEU267-PRO274 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor => ECO:0000305|PubMed:9195888 |
| Chain | Residue | Details |
| A | GLU268 | |
| B | GLU268 | |
| C | GLU268 | |
| D | GLU268 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Nucleophile => ECO:0000305|PubMed:9195888 |
| Chain | Residue | Details |
| A | CYS302 | |
| B | CYS302 | |
| C | CYS302 | |
| D | CYS302 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 24 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:9195888, ECO:0007744|PDB:1A4Z |
| Chain | Residue | Details |
| A | GLU268 | |
| A | GLU399 | |
| B | ILE166 | |
| B | LYS192 | |
| B | GLY225 | |
| B | GLY245 | |
| B | GLU268 | |
| B | GLU399 | |
| C | ILE166 | |
| C | LYS192 | |
| C | GLY225 | |
| C | GLY245 | |
| C | GLU268 | |
| C | GLU399 | |
| D | ILE166 | |
| D | LYS192 | |
| D | GLY225 | |
| D | GLY245 | |
| D | GLU268 | |
| D | GLU399 | |
| A | ILE166 | |
| A | LYS192 | |
| A | GLY225 | |
| A | GLY245 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | SITE: Transition state stabilizer => ECO:0000269|PubMed:9195888 |
| Chain | Residue | Details |
| A | ASN169 | |
| B | ASN169 | |
| C | ASN169 | |
| D | ASN169 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 40 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P47738 |
| Chain | Residue | Details |
| A | LYS358 | |
| A | LYS366 | |
| A | LYS409 | |
| A | LYS411 | |
| A | LYS424 | |
| A | LYS434 | |
| B | LYS35 | |
| B | LYS56 | |
| B | LYS142 | |
| B | LYS351 | |
| B | LYS358 | |
| B | LYS366 | |
| B | LYS409 | |
| B | LYS411 | |
| B | LYS424 | |
| B | LYS434 | |
| C | LYS35 | |
| C | LYS56 | |
| C | LYS142 | |
| C | LYS351 | |
| C | LYS358 | |
| C | LYS366 | |
| C | LYS409 | |
| C | LYS411 | |
| C | LYS424 | |
| C | LYS434 | |
| D | LYS35 | |
| D | LYS56 | |
| D | LYS142 | |
| D | LYS351 | |
| D | LYS358 | |
| D | LYS366 | |
| D | LYS409 | |
| D | LYS411 | |
| D | LYS424 | |
| D | LYS434 | |
| A | LYS35 | |
| A | LYS56 | |
| A | LYS142 | |
| A | LYS351 |
