Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1A4Y

RIBONUCLEASE INHIBITOR-ANGIOGENIN COMPLEX

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006402	biological_process	mRNA catabolic process
A	0008428	molecular_function	ribonuclease inhibitor activity
A	0016477	biological_process	cell migration
A	0030027	cellular_component	lamellipodium
A	0032311	cellular_component	angiogenin-PRI complex
A	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
A	0045765	biological_process	regulation of angiogenesis
A	0070062	cellular_component	extracellular exosome
B	0001525	biological_process	angiogenesis
B	0001541	biological_process	ovarian follicle development
B	0001556	biological_process	oocyte maturation
B	0001666	biological_process	response to hypoxia
B	0001890	biological_process	placenta development
B	0001938	biological_process	positive regulation of endothelial cell proliferation
B	0003676	molecular_function	nucleic acid binding
B	0003677	molecular_function	DNA binding
B	0003779	molecular_function	actin binding
B	0004519	molecular_function	endonuclease activity
B	0004521	molecular_function	RNA endonuclease activity
B	0004540	molecular_function	RNA nuclease activity
B	0004549	molecular_function	tRNA-specific ribonuclease activity
B	0005102	molecular_function	signaling receptor binding
B	0005507	molecular_function	copper ion binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005604	cellular_component	basement membrane
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005694	cellular_component	chromosome
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0007154	biological_process	cell communication
B	0008201	molecular_function	heparin binding
B	0009303	biological_process	rRNA transcription
B	0009725	biological_process	response to hormone
B	0010494	cellular_component	cytoplasmic stress granule
B	0015629	cellular_component	actin cytoskeleton
B	0016078	biological_process	tRNA decay
B	0016477	biological_process	cell migration
B	0017148	biological_process	negative regulation of translation
B	0019731	biological_process	antibacterial humoral response
B	0019843	molecular_function	rRNA binding
B	0023052	biological_process	signaling
B	0030041	biological_process	actin filament polymerization
B	0030139	cellular_component	endocytic vesicle
B	0030154	biological_process	cell differentiation
B	0030426	cellular_component	growth cone
B	0031410	cellular_component	cytoplasmic vesicle
B	0032055	biological_process	negative regulation of translation in response to stress
B	0032311	cellular_component	angiogenin-PRI complex
B	0034063	biological_process	stress granule assembly
B	0042277	molecular_function	peptide binding
B	0042327	biological_process	positive regulation of phosphorylation
B	0042592	biological_process	homeostatic process
B	0042803	molecular_function	protein homodimerization activity
B	0043022	molecular_function	ribosome binding
B	0043025	cellular_component	neuronal cell body
B	0043066	biological_process	negative regulation of apoptotic process
B	0045087	biological_process	innate immune response
B	0048662	biological_process	negative regulation of smooth muscle cell proliferation
B	0050714	biological_process	positive regulation of protein secretion
B	0050830	biological_process	defense response to Gram-positive bacterium
B	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
B	0071425	biological_process	hematopoietic stem cell proliferation
D	0005515	molecular_function	protein binding
D	0005634	cellular_component	nucleus
D	0005654	cellular_component	nucleoplasm
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006402	biological_process	mRNA catabolic process
D	0008428	molecular_function	ribonuclease inhibitor activity
D	0016477	biological_process	cell migration
D	0030027	cellular_component	lamellipodium
D	0032311	cellular_component	angiogenin-PRI complex
D	0034315	biological_process	regulation of Arp2/3 complex-mediated actin nucleation
D	0045765	biological_process	regulation of angiogenesis
D	0070062	cellular_component	extracellular exosome
E	0001525	biological_process	angiogenesis
E	0001541	biological_process	ovarian follicle development
E	0001556	biological_process	oocyte maturation
E	0001666	biological_process	response to hypoxia
E	0001890	biological_process	placenta development
E	0001938	biological_process	positive regulation of endothelial cell proliferation
E	0003676	molecular_function	nucleic acid binding
E	0003677	molecular_function	DNA binding
E	0003779	molecular_function	actin binding
E	0004519	molecular_function	endonuclease activity
E	0004521	molecular_function	RNA endonuclease activity
E	0004540	molecular_function	RNA nuclease activity
E	0004549	molecular_function	tRNA-specific ribonuclease activity
E	0005102	molecular_function	signaling receptor binding
E	0005507	molecular_function	copper ion binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005604	cellular_component	basement membrane
E	0005615	cellular_component	extracellular space
E	0005634	cellular_component	nucleus
E	0005694	cellular_component	chromosome
E	0005730	cellular_component	nucleolus
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0007154	biological_process	cell communication
E	0008201	molecular_function	heparin binding
E	0009303	biological_process	rRNA transcription
E	0009725	biological_process	response to hormone
E	0010494	cellular_component	cytoplasmic stress granule
E	0015629	cellular_component	actin cytoskeleton
E	0016078	biological_process	tRNA decay
E	0016477	biological_process	cell migration
E	0017148	biological_process	negative regulation of translation
E	0019731	biological_process	antibacterial humoral response
E	0019843	molecular_function	rRNA binding
E	0023052	biological_process	signaling
E	0030041	biological_process	actin filament polymerization
E	0030139	cellular_component	endocytic vesicle
E	0030154	biological_process	cell differentiation
E	0030426	cellular_component	growth cone
E	0031410	cellular_component	cytoplasmic vesicle
E	0032055	biological_process	negative regulation of translation in response to stress
E	0032311	cellular_component	angiogenin-PRI complex
E	0034063	biological_process	stress granule assembly
E	0042277	molecular_function	peptide binding
E	0042327	biological_process	positive regulation of phosphorylation
E	0042592	biological_process	homeostatic process
E	0042803	molecular_function	protein homodimerization activity
E	0043022	molecular_function	ribosome binding
E	0043025	cellular_component	neuronal cell body
E	0043066	biological_process	negative regulation of apoptotic process
E	0045087	biological_process	innate immune response
E	0048662	biological_process	negative regulation of smooth muscle cell proliferation
E	0050714	biological_process	positive regulation of protein secretion
E	0050830	biological_process	defense response to Gram-positive bacterium
E	0061844	biological_process	antimicrobial humoral immune response mediated by antimicrobial peptide
E	0071425	biological_process	hematopoietic stem cell proliferation

Functional Information from PROSITE/UniProt

site_id	PS00127
Number of Residues	7
Details	RNASE_PANCREATIC Pancreatic ribonuclease family signature. CKdiNTF

Chain	Residue	Details
B	CYS39-PHE45

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000269\|PubMed:11468363, ECO:0000269\|PubMed:9918722

Chain	Residue	Details
B	HIS13
E	HIS13

site_id	SWS_FT_FI2
Number of Residues	2
Details	ACT_SITE: Proton donor => ECO:0000269\|PubMed:11468363, ECO:0000269\|PubMed:9918722

Chain	Residue	Details
B	HIS114
E	HIS114

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING:

Chain	Residue	Details
B	LYS40
E	LYS40

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid => ECO:0000269\|PubMed:2866794

Chain	Residue	Details
B	GLN1
E	GLN1

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	a catalytic site defined by CSA, PubMed 2479414, 2497770

Chain	Residue	Details
B	HIS13
B	LYS40
B	HIS114

site_id	MCSA1
Number of Residues	3
Details	M-CSA 564

Chain	Residue	Details
B	HIS13	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
B	LYS40	electrostatic stabiliser
B	HIS114	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor

site_id	MCSA2
Number of Residues	3
Details	M-CSA 564

Chain	Residue	Details
E	HIS13	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor
E	LYS40	electrostatic stabiliser
E	HIS114	increase nucleophilicity, promote heterolysis, proton acceptor, proton donor

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)