Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1A4E

CATALASE A FROM SACCHAROMYCES CEREVISIAE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000302	biological_process	response to reactive oxygen species
A	0004096	molecular_function	catalase activity
A	0004601	molecular_function	peroxidase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005759	cellular_component	mitochondrial matrix
A	0005777	cellular_component	peroxisome
A	0005782	cellular_component	peroxisomal matrix
A	0006979	biological_process	response to oxidative stress
A	0016491	molecular_function	oxidoreductase activity
A	0020037	molecular_function	heme binding
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0046872	molecular_function	metal ion binding
A	0098869	biological_process	cellular oxidant detoxification
B	0000302	biological_process	response to reactive oxygen species
B	0004096	molecular_function	catalase activity
B	0004601	molecular_function	peroxidase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005759	cellular_component	mitochondrial matrix
B	0005777	cellular_component	peroxisome
B	0005782	cellular_component	peroxisomal matrix
B	0006979	biological_process	response to oxidative stress
B	0016491	molecular_function	oxidoreductase activity
B	0020037	molecular_function	heme binding
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0046872	molecular_function	metal ion binding
B	0098869	biological_process	cellular oxidant detoxification
C	0000302	biological_process	response to reactive oxygen species
C	0004096	molecular_function	catalase activity
C	0004601	molecular_function	peroxidase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005759	cellular_component	mitochondrial matrix
C	0005777	cellular_component	peroxisome
C	0005782	cellular_component	peroxisomal matrix
C	0006979	biological_process	response to oxidative stress
C	0016491	molecular_function	oxidoreductase activity
C	0020037	molecular_function	heme binding
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0046872	molecular_function	metal ion binding
C	0098869	biological_process	cellular oxidant detoxification
D	0000302	biological_process	response to reactive oxygen species
D	0004096	molecular_function	catalase activity
D	0004601	molecular_function	peroxidase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005759	cellular_component	mitochondrial matrix
D	0005777	cellular_component	peroxisome
D	0005782	cellular_component	peroxisomal matrix
D	0006979	biological_process	response to oxidative stress
D	0016491	molecular_function	oxidoreductase activity
D	0020037	molecular_function	heme binding
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0046872	molecular_function	metal ion binding
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE AZI A 504

Chain	Residue
A	HIS70
A	ASN143
A	PHE148
A	PHE156
A	HEM503

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AZI B 504

Chain	Residue
B	PHE156
B	HEM503
B	PRO69
B	HIS70
B	ASN143
B	PHE148

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AZI C 504

Chain	Residue
C	PRO69
C	HIS70
C	ASN143
C	PHE148
C	PHE156
C	HEM503

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE AZI D 504

Chain	Residue
D	PRO69
D	HIS70
D	ASN143
D	PHE148
D	PHE156
D	HEM503

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1

Chain	Residue
A	ARG61
B	ARG360
B	TYR361
B	HOH608
C	ARG61
D	ARG360
D	TYR361
D	HOH601

site_id	AC6
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 D 2

Chain	Residue
A	ARG360
A	TYR361
A	HOH604
B	ARG61
C	ARG360
C	TYR361
C	HOH606
D	ARG61

site_id	AC7
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM A 503

Chain	Residue
A	ARG67
A	ASN68
A	PRO69
A	HIS70
A	ARG107
A	GLY126
A	VAL141
A	TYR142
A	ASN143
A	PHE156
A	SER213
A	PHE331
A	VAL347
A	ARG351
A	SER354
A	TYR355
A	ALA358
A	HIS359
A	ARG362
A	AZI504
A	HOH506
A	HOH509
A	HOH514
D	ASN60

site_id	AC8
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM B 503

Chain	Residue
B	ARG67
B	ASN68
B	HIS70
B	ARG107
B	GLY126
B	VAL141
B	TYR142
B	ASN143
B	PHE156
B	SER213
B	HIS215
B	PHE331
B	VAL347
B	ARG351
B	SER354
B	TYR355
B	HIS359
B	ARG362
B	AZI504
B	HOH511
B	HOH515
B	HOH523
C	ASN60

site_id	AC9
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM C 503

Chain	Residue
C	VAL347
C	ARG351
C	SER354
C	TYR355
C	ALA358
C	HIS359
C	ARG362
C	AZI504
C	HOH510
C	HOH515
C	HOH521
B	ASN60
C	ARG67
C	ASN68
C	HIS70
C	ARG107
C	GLY126
C	VAL141
C	TYR142
C	ASN143
C	PHE148
C	PHE156
C	SER213
C	PHE331

site_id	BC1
Number of Residues	24
Details	BINDING SITE FOR RESIDUE HEM D 503

Chain	Residue
A	ASN60
D	ARG67
D	ASN68
D	HIS70
D	ARG107
D	GLY126
D	VAL141
D	TYR142
D	ASN143
D	PHE148
D	PHE156
D	SER213
D	PHE331
D	VAL347
D	ARG351
D	SER354
D	TYR355
D	ALA358
D	HIS359
D	ARG362
D	AZI504
D	HOH517
D	HOH521
D	HOH526

Functional Information from PROSITE/UniProt

site_id	PS00437
Number of Residues	9
Details	CATALASE_1 Catalase proximal heme-ligand signature. RLFSYaDAH

Chain	Residue	Details
A	ARG351-HIS359

site_id	PS00438
Number of Residues	17
Details	CATALASE_2 Catalase proximal active site signature. FnRenipQRnpHahGSG

Chain	Residue	Details
A	PHE59-GLY75

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Active site: {"evidences":[{"source":"PubMed","id":"9931255","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"description":"axial binding residue","evidences":[{"source":"PubMed","id":"9931255","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
A	SER109
A	ASN143
A	HIS70

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
B	SER109
B	ASN143
B	HIS70

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
C	SER109
C	ASN143
C	HIS70

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1iph

Chain	Residue	Details
D	SER109
D	ASN143
D	HIS70

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)