1A41
TYPE 1-TOPOISOMERASE CATALYTIC FRAGMENT FROM VACCINIA VIRUS
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | ARG84 |
| A | LYS257 |
| A | SER268 |
| A | SER270 |
| A | LYS271 |
Functional Information from PROSITE/UniProt
| site_id | PS00176 |
| Number of Residues | 19 |
| Details | TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EvvghtpSISKraYMattI |
| Chain | Residue | Details |
| A | GLU261-ILE279 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:15755148 |
| Chain | Residue | Details |
| A | TYR274 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Involved in religation => ECO:0000250|UniProtKB:P32989 |
| Chain | Residue | Details |
| A | ASP168 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 5 |
| Details | M-CSA 232 |
| Chain | Residue | Details |
| A | ARG130 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | LYS167 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor, proton acceptor, proton donor, proton relay |
| A | ARG223 | attractive charge-charge interaction, electrostatic stabiliser, hydrogen bond donor |
| A | HIS265 | electrostatic stabiliser, hydrogen bond donor |
| A | TYR274 | hydrogen bond acceptor, hydrogen bond donor, nucleofuge, nucleophile, proton acceptor, proton donor |
