Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004303 | molecular_function | estradiol 17-beta-dehydrogenase [NAD(P)+] activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006703 | biological_process | estrogen biosynthetic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE EST A 350 |
| Chain | Residue |
| A | MET193 |
| A | VAL225 |
| A | PHE259 |
| A | MET279 |
| A | NAP360 |
| A | HOH570 |
| A | HOH628 |
| A | SER142 |
| A | VAL143 |
| A | GLY144 |
| A | MET147 |
| A | LEU149 |
| A | TYR155 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAP A 360 |
| Chain | Residue |
| A | GLY9 |
| A | SER11 |
| A | SER12 |
| A | GLY13 |
| A | ILE14 |
| A | ARG37 |
| A | LEU64 |
| A | ASP65 |
| A | VAL66 |
| A | ARG67 |
| A | ASN90 |
| A | ALA91 |
| A | GLY92 |
| A | THR140 |
| A | GLY141 |
| A | SER142 |
| A | TYR155 |
| A | LYS159 |
| A | CYS185 |
| A | GLY186 |
| A | PRO187 |
| A | VAL188 |
| A | THR190 |
| A | PHE192 |
| A | LYS195 |
| A | EST350 |
| A | HOH524 |
| A | HOH525 |
| A | HOH537 |
| A | HOH550 |
| A | HOH573 |
| A | HOH603 |
| A | HOH605 |
| A | HOH618 |
| site_id | CAT |
| Number of Residues | 3 |
| Details | CATALYTIC SITE. |
| Chain | Residue |
| A | SER142 |
| A | TYR155 |
| A | LYS159 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SvgglmglpfNdvYCASKFALeGLCeSLA |
| Chain | Residue | Details |
| A | SER142-ALA170 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton acceptor"} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 31 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8805577","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"PubMed","id":"8994190","evidenceCode":"ECO:0000269"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| A | ASN152 | |
| A | LYS159 | |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1qsg |
| Chain | Residue | Details |
| A | TYR155 | |
| A | LYS159 | |
