Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003690 | molecular_function | double-stranded DNA binding |
| A | 0003909 | molecular_function | DNA ligase activity |
| A | 0003910 | molecular_function | DNA ligase (ATP) activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0006260 | biological_process | DNA replication |
| A | 0006281 | biological_process | DNA repair |
| A | 0006310 | biological_process | DNA recombination |
| A | 0006974 | biological_process | DNA damage response |
| A | 0016874 | molecular_function | ligase activity |
| A | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ATP A 1 |
| Chain | Residue |
| A | GLU32 |
| A | LYS222 |
| A | LYS232 |
| A | TRP236 |
| A | LYS238 |
| A | HOH351 |
| A | HOH434 |
| A | HOH459 |
| A | ILE33 |
| A | LYS34 |
| A | TYR35 |
| A | ARG39 |
| A | ARG55 |
| A | GLU93 |
| A | TYR149 |
| A | ILE220 |
Functional Information from PROSITE/UniProt
| site_id | PS00333 |
| Number of Residues | 24 |
| Details | DNA_LIGASE_A2 ATP-dependent DNA ligase signature 2. EGLIVKdpmci...YKrgk...Ksgww.KMK |
| Chain | Residue | Details |
| A | GLU217-LYS240 | |
| site_id | PS00697 |
| Number of Residues | 9 |
| Details | DNA_LIGASE_A1 ATP-dependent DNA ligase AMP-binding site. EIKYDGVRG |
| Chain | Residue | Details |
| A | GLU32-GLY40 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"N6-AMP-lysine intermediate","evidences":[{"source":"PROSITE-ProRule","id":"PRU10135","evidenceCode":"ECO:0000255"}]} |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8653795","evidenceCode":"ECO:0000269"}]} |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"8653795","evidenceCode":"ECO:0000305"}]} |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | a catalytic site defined by CSA, PubMed 11106756, 1988940, 10656817 |
| Chain | Residue | Details |
| A | LYS34 | |
| A | LYS238 | |
| A | LYS240 | |
| site_id | MCSA1 |
| Number of Residues | 3 |
| Details | M-CSA 202 |
| Chain | Residue | Details |
| A | LYS34 | hydrogen bond donor, nucleofuge, nucleophile, polar interaction |
| A | LYS238 | electrostatic stabiliser, hydrogen bond donor, steric role |
| A | LYS240 | electrostatic stabiliser, hydrogen bond donor |
