12IY
Locally refined cryo-EM structure of human cannabinoid receptor 2 with agonist '5249
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| R | 0001975 | biological_process | response to amphetamine |
| R | 0004930 | molecular_function | G protein-coupled receptor activity |
| R | 0004949 | molecular_function | cannabinoid receptor activity |
| R | 0005515 | molecular_function | protein binding |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0005783 | cellular_component | endoplasmic reticulum |
| R | 0005886 | cellular_component | plasma membrane |
| R | 0007154 | biological_process | cell communication |
| R | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| R | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| R | 0023052 | biological_process | signaling |
| R | 0030425 | cellular_component | dendrite |
| R | 0031234 | cellular_component | extrinsic component of cytoplasmic side of plasma membrane |
| R | 0032229 | biological_process | negative regulation of synaptic transmission, GABAergic |
| R | 0032496 | biological_process | response to lipopolysaccharide |
| R | 0033004 | biological_process | negative regulation of mast cell activation |
| R | 0038171 | biological_process | cannabinoid signaling pathway |
| R | 0043025 | cellular_component | neuronal cell body |
| R | 0043204 | cellular_component | perikaryon |
| R | 0045211 | cellular_component | postsynaptic membrane |
| R | 0045471 | biological_process | response to ethanol |
| R | 0045669 | biological_process | positive regulation of osteoblast differentiation |
| R | 0045759 | biological_process | negative regulation of action potential |
| R | 0099553 | biological_process | trans-synaptic signaling by endocannabinoid, modulating synaptic transmission |
Functional Information from PROSITE/UniProt
| site_id | PS00237 |
| Number of Residues | 17 |
| Details | G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. ASVgSLLLTAIDRYLcL |
| Chain | Residue | Details |
| R | ALA119-LEU135 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 30 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 37 |
| Details | Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 24 |
| Details | Transmembrane: {"description":"Helical; Name=3","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | Transmembrane: {"description":"Helical; Name=4","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 25 |
| Details | Transmembrane: {"description":"Helical; Name=5","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 20 |
| Details | Transmembrane: {"description":"Helical; Name=6","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 21 |
| Details | Transmembrane: {"description":"Helical; Name=7","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
