9SXJ
Crystal structure of wild-type c-MET bound by capmatinib.
This is a non-PDB format compatible entry.
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | DIAMOND BEAMLINE I03 |
| Synchrotron site | Diamond |
| Beamline | I03 |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2024-02-12 |
| Detector | DECTRIS EIGER X 16M |
| Wavelength(s) | 0.97625 |
| Spacegroup name | P 1 21 1 |
| Unit cell lengths | 37.681, 41.752, 83.309 |
| Unit cell angles | 90.00, 91.88, 90.00 |
Refinement procedure
| Resolution | 18.830 - 1.315 |
| R-factor | 0.215 |
| Rwork | 0.214 |
| R-free | 0.23080 |
| Structure solution method | MOLECULAR REPLACEMENT |
| RMSD bond length | 0.012 |
| RMSD bond angle | 1.170 |
| Data reduction software | autoPROC |
| Data scaling software | autoPROC |
| Phasing software | PHASER |
| Refinement software | BUSTER (2.11.8) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 83.260 | 1.340 |
| High resolution limit [Å] | 1.320 | 1.320 |
| Number of reflections | 56010 | 1841 |
| <I/σ(I)> | 6.8 | |
| Completeness [%] | 90.7 | |
| Redundancy | 3 | |
| CC(1/2) | 0.996 | 0.372 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 293 | 30% PEG3350, 0.2 M MgCl2, 0.1 M PCTP pH 7.5 |
