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8F1Y

EGFR kinase in complex with poziotinib

Experimental procedure
Experimental methodSINGLE WAVELENGTH
Source typeSYNCHROTRON
Source detailsAPS BEAMLINE 24-ID-C
Synchrotron siteAPS
Beamline24-ID-C
Temperature [K]100
Detector technologyPIXEL
Collection date2021-07-23
DetectorDECTRIS EIGER X 16M
Wavelength(s)0.97918
Spacegroup nameI 2 3
Unit cell lengths145.572, 145.572, 145.572
Unit cell angles90.00, 90.00, 90.00
Refinement procedure
Resolution59.430 - 2.750
R-factor0.2061
Rwork0.205
R-free0.22820
Structure solution methodMOLECULAR REPLACEMENT
Starting model (for MR)2gs2
Data reduction softwarexia2
Data scaling softwarexia2
Phasing softwarePHASER
Refinement softwarePHENIX (1.20.1_4487)
Data quality characteristics
 OverallInner shellOuter shell
Low resolution limit [Å]59.43059.4402.800
High resolution limit [Å]2.7507.4602.750
Rmeas0.1570.0871.464
Rpim0.0690.0400.638
Total number of observations6781533443518
Number of reflections13469706676
<I/σ(I)>8.319.81.1
Completeness [%]99.797.1100
Redundancy54.75.2
Crystallization Conditions
crystal IDmethodpHtemperaturedetails
1VAPOR DIFFUSION, HANGING DROP6.52930.1 M MES pH=6.5, 1.1 M Sodium Citrate

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