8AU5
c-MET F1200I mutant in complex with Tepotinib
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SYNCHROTRON |
| Source details | SLS BEAMLINE X06SA |
| Synchrotron site | SLS |
| Beamline | X06SA |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2013-04-16 |
| Detector | PSI PILATUS 6M |
| Wavelength(s) | 1.00000 |
| Spacegroup name | P 1 21 1 |
| Unit cell lengths | 38.484, 43.173, 88.794 |
| Unit cell angles | 90.00, 91.67, 90.00 |
Refinement procedure
| Resolution | 88.760 - 2.720 |
| R-factor | 0.2386 |
| Rwork | 0.234 |
| R-free | 0.27780 |
| Structure solution method | MOLECULAR REPLACEMENT |
| Starting model (for MR) | 4r1v |
| RMSD bond length | 0.009 |
| RMSD bond angle | 1.052 |
| Data reduction software | XDS |
| Data scaling software | XSCALE |
| Phasing software | MOLREP |
| Refinement software | REFMAC (5.5.0109) |
Data quality characteristics
| Overall | Outer shell | |
| Low resolution limit [Å] | 88.760 | 2.970 |
| High resolution limit [Å] | 2.720 | 2.720 |
| Rmeas | 0.061 | 0.577 |
| Number of reflections | 7637 | 1783 |
| <I/σ(I)> | 14.16 | 2.88 |
| Completeness [%] | 95.0 | 96.7 |
| Redundancy | 2.9 | 2.8 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION | 7.6 | 293 | PEG 8000 |
