8AU5
c-MET F1200I mutant in complex with Tepotinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hepatocyte growth factor receptor | polymer | 299 | 33910.4 | 1 | UniProt (P08581) Pfam (PF07714) | Homo sapiens (human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
| 2 | B (A) | 3-[1-(3-{5-[(1-methylpiperidin-4-yl)methoxy]pyrimidin-2-yl}benzyl)-6-oxo-1,6-dihydropyridazin-3-yl]benzonitrile | non-polymer | 492.6 | 1 | Chemie (3E8) | |||
| 3 | C, D, F (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
| 4 | E (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | G (A) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 1051 - 1349 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Ile 1200 | Phe 1200 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33910.4 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 714.2 | |
| All* | Total formula weight | 34624.6 |
