6TEN
Crystal structure of Dot1L in complex with an inhibitor (compound 11).
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | SYNCHROTRON |
Source details | SLS BEAMLINE X10SA |
Synchrotron site | SLS |
Beamline | X10SA |
Temperature [K] | 100 |
Detector technology | PIXEL |
Collection date | 2014-11-28 |
Detector | DECTRIS PILATUS3 S 6M |
Wavelength(s) | 0.99994 |
Spacegroup name | P 63 |
Unit cell lengths | 158.475, 158.475, 74.799 |
Unit cell angles | 90.00, 90.00, 120.00 |
Refinement procedure
Resolution | 45.750 - 2.210 |
R-factor | 0.18 |
Rwork | 0.179 |
R-free | 0.20100 |
Structure solution method | MOLECULAR REPLACEMENT |
Starting model (for MR) | 5drt |
RMSD bond length | 0.010 |
RMSD bond angle | 0.990 |
Data reduction software | XDS |
Data scaling software | XSCALE |
Phasing software | PHASER |
Refinement software | BUSTER |
Data quality characteristics
Overall | Inner shell | Outer shell | |
Low resolution limit [Å] | 45.750 | 45.750 | 2.270 |
High resolution limit [Å] | 2.210 | 9.880 | 2.210 |
Rmerge | 0.099 | 0.048 | 1.278 |
Rmeas | 0.104 | 0.050 | 1.345 |
Total number of observations | 555646 | ||
Number of reflections | 53796 | 634 | 4000 |
<I/σ(I)> | 14.82 | 42.36 | 2.12 |
Completeness [%] | 100.0 | 98.8 | 100 |
Redundancy | 10.329 | 10.476 | 10.276 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION | 293 | 1.5 M Li sulfate 0.1 M Hepes pH 7.0 |