6C18
FGFR1 kinase complex with inhibitor SN37115
Experimental procedure
Experimental method | SINGLE WAVELENGTH |
Source type | ROTATING ANODE |
Source details | RIGAKU MICROMAX-007 HF |
Temperature [K] | 110 |
Detector technology | IMAGE PLATE |
Collection date | 2015-01-24 |
Detector | MAR scanner 345 mm plate |
Wavelength(s) | 1.5418 |
Spacegroup name | C 1 2 1 |
Unit cell lengths | 208.962, 49.837, 65.085 |
Unit cell angles | 90.00, 106.19, 90.00 |
Refinement procedure
Resolution | 19.780 - 2.300 |
R-factor | 0.22481 |
Rwork | 0.223 |
R-free | 0.26668 |
Structure solution method | MOLECULAR REPLACEMENT |
Starting model (for MR) | 4wun |
RMSD bond length | 0.011 |
RMSD bond angle | 1.509 |
Data reduction software | XDS |
Data scaling software | Aimless |
Phasing software | PHASER |
Refinement software | REFMAC (5.8.0049) |
Data quality characteristics
Overall | Outer shell | |
Low resolution limit [Å] | 19.780 | 2.380 |
High resolution limit [Å] | 2.300 | 2.300 |
Rmerge | 0.142 | |
Rpim | 0.060 | 0.612 |
Number of reflections | 28937 | 2836 |
<I/σ(I)> | 11.8 | 1.5 |
Completeness [%] | 99.8 | 100 |
Redundancy | 7.4 | 7.3 |
CC(1/2) | 0.997 | 0.599 |
Crystallization Conditions
crystal ID | method | pH | temperature | details |
1 | VAPOR DIFFUSION, HANGING DROP | 291 | 20% MPEG 5000, 0.1 M sodium cacodylate pH 7.5, 0.2 M ammonium sulfate |