5WBX
Structural insights into the potency of SK/IK channel positive modulators
Experimental procedure
| Experimental method | SINGLE WAVELENGTH |
| Source type | SEALED TUBE |
| Source details | BRUKER D8 QUEST |
| Temperature [K] | 100 |
| Detector technology | PIXEL |
| Collection date | 2016-11-03 |
| Detector | Bruker PHOTON II |
| Wavelength(s) | 1.3148 |
| Spacegroup name | C 1 2 1 |
| Unit cell lengths | 77.328, 66.091, 65.435 |
| Unit cell angles | 90.00, 93.84, 90.00 |
Refinement procedure
| Resolution | 26.836 - 1.900 |
| R-factor | 0.1907 |
| Rwork | 0.188 |
| R-free | 0.24280 |
| Data reduction software | XPREP |
| Data scaling software | XPREP |
| Phasing software | PHASER |
| Refinement software | REFMAC |
Data quality characteristics
| Overall | |
| Low resolution limit [Å] | 26.840 |
| High resolution limit [Å] | 1.900 |
| Number of reflections | 25882 |
| <I/σ(I)> | 14.9 |
| Completeness [%] | 98.4 |
| Redundancy | 6.4 |
Crystallization Conditions
| crystal ID | method | pH | temperature | details |
| 1 | VAPOR DIFFUSION, SITTING DROP | 5.8 | 293.15 | 0.1 M Sodium itrate tribasic dihydrate 0.5 M Ammonium sulfate 1.5 M Lithium sulfate monohydrate |
